«123»Seite
3 articles, page 1 of 3

Review article

Male Sexual Dysfunction: Diagnosis and Treatment From a Sexological and Interdisciplinary Perspective

Dtsch Arztebl Int 2009; 106(50): 821-8; DOI: 10.3238/arztebl.2009.0821

Rösing, D; Klebingat, K; Berberich, H J; Bosinski, H A G; Loewit, K; Beier, K M

Universitätsklinikum Greifswald, Klinik und Poliklinik für Urologie: Dr. med. Rösing, Prof. Dr. med. Klebingat
Praxis für Urologie, Frankfurt a. M.: Dr. med. Berberich;
Sektion für Sexualmedizin im Universitätsklinikum Schleswig-Holstein, Campus Kiel: Prof. Dr. med. Bosinski;
Universitäts-Klinik für Medizinische Psychologie und Psychotherapie, Sexualmedizinische Ambulanz, Innsbruck: em. Prof. Dr. med. Loewit;
Institut für Sexualwissenschaft und Sexualmedizin, Charité – Universitätsmedizin Berlin: Prof. Dr. med. Dr. phil. Beier
Background: Among all types of sexual disturbance in men, disturbances of sexual function are the most important in clinical practice. These are classified by the segment of the sexual reaction cycle in which they arise (appetence, arousal, orgasm, and resolution). Partial functional impairment must be distinguished from dysfunction causing significant suffering and requiring treatment.
Methods: The authors’ clinical experience is supplemented with a selective review of the literature on sexual dysfunction, its association with underlying diseases, and its impact on sexual and relational satisfaction.
Results: The sexual history (including the partner’s sexual history, as far as this can be obtained) is of prime importance in the diagnostic evaluation of sexual disturbances. This evaluation must take the multidimensionality and multiple functions of human sexuality into account. Chronic frustration of the fundamental psychosocial needs for acceptance, closeness, and security is a very important factor that has been neglected until now by the prevailing conceptions of the etiology and pathogenesis of sexual disturbances. Their treatment involves a combination of elements from sexual medicine and psychotherapy, along with somatic medical and pharmacotherapeutic intervention, if needed. The goal of syndyastic sex therapy, a further development of the previous therapies, is to fulfill these fundamental needs and thereby to improve the patient’s sexual function and deepen his satisfaction with the rela-tionship in its entirety.
Conclusions: It is essential to understand the different types of sexual disturbance in their biopsychosocial context as well as the significance of sexuality for the individual, and for the couple, with respect to reproduction, sexual pleasure, and bonding. Sexual disturbances are common, and patients therefore expect their physicians to be proficient in sexual medicine. The coverage of this subject in both undergraduate and postgraduate medical education in Germany needs to be improved.
Key words: sexual medicine, sexual history, sexual dysfunction, basic psychosocial needs, couples therapy
The spectrum of sexual dysfunction is wide ranging, and inadequately captured by the ICD-10 and DSM-IV classifications. In addition to functional sexual disorders, which may or may not be associated with organic pathology, disorders of sexual development, gender identity, sexual preference (paraphilia) and sexual behaviour can occur in men (1).

Epidemiology
Sexual disorders in men are categorized according to their occurrence in the cycle of sexual response into disorders of desire, arousal (erectile dysfunction), or orgasm (premature or delayed ejaculation, or anorgasmia), albeit with considerable potential for overlap and concurrence between these disorder groups.

Laumann et al. (1999) found in a representative cross sectional study of 18 to 59 year old US citizens a 5% prevalence of desire or erectile dysfunction and a 21% prevalence of premature ejaculation (2). International comparison (Laumann, et al. 2005) revealed some similarities, but also significant intercultural variations corroborating the biopsychosocial etiology of these disorders. (2, e1). A number of studies have also confirmed the negative effects of functional sexual disorders on relationships and quality of life (36).

Desire disorders
Desire disorders increasingly present as a problem among men seeking medical help for sexual difficulties. Erectile dysfunction is often presented as the primary complaint, but it is not uncommon for this to mask other problems such as exhaustion (with or without substance abuse), relationship difficulties, and, more rarely, disorders of sexual preference. Organic causes (testosterone deficiency, hyperprolactinemia, medication-related side effects) are important, but at times overemphasized in the somatic medical literature.

Erectile dysfunction
The prevalence of erectile dysfunction has been well researched. The Massachusetts Male Aging Study (MMAS) (Feldman, et al. 1994) found minimal erectile dysfunction in 17% of the 40–70 year old respondents, moderate erectile dysfunction in 25%, and complete erectile failure in 10% (7). Braun and colleagues (2000) found erectile dysfunction in 19.2% of their 4489 respondent over 30 years, although the authors demonstrated that not all participants with erectile dysfunction reported distress. In relation to both distress and overall prevalence, a marked age effect was found (8) (Tabelle 1). An important finding of these studies was the high coincidence with medical conditions (in particular -diabetes mellitus, cardiac disease, and hypertension). The onset of erectile dysfunction over the age of 40 can be an early warning sign of chronic ischemic heart disease (9, e2).

Premature ejaculation
Premature ejaculation is the commonest form of sexual dysfunction in men. It is defined as the persistent or repeated occurrence of ejaculation before, during, or shortly after penetration, over which the individual has little or no control and not accompanied by a feeling of orgasmic satisfaction. Around 20% to 25% of surveyed adult men in modern industrialized nations report premature ejaculation associated with distress (10, e3). In seeking to present valid prevalence data one encounters two problems: On the one hand, the normal interval between penetration and ejaculation is to a large extent a subjective judgment, and subject to wide individual and cultural variation (11, e4). And on the other hand, this is an area in which it is particularly clear that biological dysfunction is not synonymous with a clinically relevant disorder.

The aim of this article is to present an overview of male sexual dysfunction from a sexual medicine* and interdisciplinary perspective. Because of their prevalence, particular attention will be paid to the diagnosis and treatment of functional disorders, which are the subject of numerous treatment approaches. The relational aspects of human sexuality are accorded particular importance in a biopsychosocial sexological approach, which is underpinned by a selective literature review.

Background and diagnosis
Extensive research results from the last 15 years and the introduction of selective phosphodiesterase 5 inhibitors have led to changes in the diagnostics and treatment of male sexual dysfunction. Invasive investigation is now almost obsolete. Medication is introduced early. Success is measured in terms of function, which in turn is measured using questionnaire instruments such as the IIEF (International Index of Erectile Function), its short version (IIEF-5), or the Cologne Erectile Dysfunction Questionnaire (Kölner Erfassungsbogen der Erektilen Dysfunktion, KEED) (8, 12, e5, e6). Erectile dysfunction is generally regarded in the literature primarily as a vascular disorder, acting as a first sign of generalized atherosclerosis (e6). The view of this disorder has changed from an almost entirely psychogenic to an organically dominated, multifactorial etiology (13). A large proportion of studies on male sexual dysfunction is directed at the effects of pharmacological treatment on desire, erection and ejaculation, and remains purely at the level of the functional disorder. The discovery of highly effective oral medications by the pharmaceutical industry have quite literally created a ”potent“ new market (e7). It is true that the predominantly somatically focussed literature alludes in general terms to the role played by psychological and relational factors (10), and consensus statements emphasize the importance of a full sexual history taking into account the relationship (14). In clinical practice, however the norm is to focus in a shorthand way on “functional repair,” marginalizing or completely neglecting psychosocial and psychosexual (relationship) aspects.

Sexual experience always comprises a synergy of biological, psychological and social factors, whose -individual weighting and interrelation where a sexual problem exists must be identified on an individual patient basis. Of primary importance is the subjective meaning of sexuality and partnership, which in turn determines the effects of events and experiences within the intimate relationship (15, e7). Against this background, any diagnostic approach which considers only the physical (sexual function, for example, desire, erection, and ejaculation) or the emotional (for example, personality development and characteristics) or the relationship is necessarily incomplete and inadequate as a means of planning the treatment of sexual dysfunction accompanied by distress. Distress arises when a sense of ones own sexual inadequacy arises in the context of a relationship. The desire for relationship is innate and therefore ubiquitous (16, e17). Positive social interactions which fulfil fundamental psychosocial needs such as the need for acceptance, belonging, closeness or warmth, promote confidence, reduce anxiety, promote security, and reduce stress and aggression. This is supported by neurobiological data on the importance of attachment and relationship (17). Similarly, MRI studies hint at a specific neuronal correlate for ”love“ (18). A factor hitherto largely neglected by etiopathogenetic approaches but which appears influential is the chronic frustration of basic psychosocial needs. This leads not only to deterioration of the quality of relationship, but also affects sexuality in three areas: reproduction, desire, and relationship. In a recent interview based study by Kleinplatz et al. (2007), men and women over 65 and in long term relationships cited factors such as authenticity, intense emotional connection, communication, and a sense of being accepted as characteristics of “great sex” (19). Sexuality as “the deepest act of communication” is not a new idea, and the extension of “tactile communication during sex” to “an additional language,” was described more than 50 years ago (e15). Couples therapy makes this language conscious, and translates it: attraction, acceptance, closeness, and security are communicated and embodied in sexual body language, as well as in other ways. The German word used for couples therapy, “syndiastic,” derives from the Greek word syndyastikós (“orientated towards mutuality in a couple relationship”).

Aristotle elucidates in his Nikomachean Ethics the idea of “becoming close to one another“ (synoikeioústhai) in the sense of “belonging together.” He distinguishes this from the relationship with a significant other found between members of a couple (syndyastikós), in which particularly intense feelings of trust and belonging can develop (15). This does not necessarily presuppose sexual functionality, nor is sexual functionality sufficient to create sexually satisfying experiences (19).

Basic psychosocial needs are therefore capable of being fulfilled in a unique way via sexual “body--language.” Their chronic frustration via dysfunctional or absent (intimate) physical contact, plays a key role in the development and maintenance of psychosomatic disorders, including all functional sexual disorders, and impedes recovery from existing illness (e8). On the other hand, recent studies of the placebo effect have shown that the effect of medicines is frequently enhanced by the supportive attention received in the consultation, in addition to the attribution effect, which arises from a positive expectation of treatment. Even the Drug Commission of the German Medical Association (Arzneimittelkommission der deutschen Ärzteschaft) has reached the conclusion that “doctor-patient relationships characterized by trust, empathy, and hope are therapeutically effective“ (e16). If, reasonably enough, we accept the placebo effect of the good doctor-patient relationship, we should value all the more highly the health promoting potential of a functioning intimate relationship, and seek to influence it positively.

If one wants to attain a perspective commensurate with the complex realities of the situation, sexual -history taking, as an important diagnostic tool requiring attention to details not usually elicited in the standard medical history, requires specialist knowledge and qualification (20, e9, e10) (Box gif ppt).

The importance of the various dimensions of sexual history taking was emphasized by the results of the Berlin Men Study (Berliner Männerstudie). This study asked a representative sample of 6000 men aged 40–79 about erectile dysfunction and its effects on quality of life, health, and their relationship (21). A subgroup analysis of participants who completed an extensive interview including a full sexual history in the presence of their partner (in total 373 men), not only demonstrated the prevalence of the various functional disorders, but also found that 46.9% reported fantasies used in the arousal phase of masturbation which could be classified as paraphilias (for example fetishistic, masochistic, sadistic, or exhibitionistic fantasies). From the perspective of sexual medicine, paraphilia-like arousal patterns are not in themselves pathological, while the importance of the fantasy in the process of -arousal was frequently reported by participants to be “moderate,” and only occasionally as “strong.” -Generalization from this population to the background population is inappropriate due to likely selection bias. Nevertheless, as many as a third of men described the paraphilia-like fantasies alone as inadequate, and in a significant proportion of these, there was a risk of harm to others (for example pedophilic, exhibitionistic, or frotteuristic content of the fantasies), some of which had already been acted upon (15). These data (which represent a tiny group, as the men were over 40), suggest that a diagnostic focus solely on function can very occasionally lead to a “cosmetic” approach to symptoms which leaves important underlying issues unexplored. One example of this is the inappropriate treatment of erectile dysfunction arising in a severe but unrecognized disorder of sexual preference with PDE 5 inhibitors (22, e11).

Functional sexual disorders in men are common complications of illness or its treatment, or early signs of disease. For this reason it is important across medical specialties to include a sexual and relationship -history into a general medical history, and where appropriate introduce additional enquiry and investigation (Figure gif ppt, Table 2 gif ppt). This offers patients (or couples) wishing for change or treatment but reluctant to express this the opportunity to discuss their concerns and receive early intervention. The extent of treatment efficacy is dependent on the timing of diagnosis. The prognosis is good where distressing sexual dysfunction is recognized early (at first presentation) and receives expert treatment. Otherwise, there is a danger that the problem will become chronic (1).

Treatment
The biopsychosocial etiology of sexual dysfunction calls for a biopsychosocial approach to treatment, -involving the methods of ”narrative medicine“ as well as organic and pharmacological approaches (Table 3 gif ppt).

Using the example of the treatment of patients in Germany suffering from erectile dysfunction following radical prostatectomy for prostate cancer, Herkommer et al. (2006) were able to demonstrate that the long term use of solely pharmacological or mechanical treatments were associated with less satisfaction with therapy among patients than estimated by urologists. There was also discrepancy between the views of patients and clinicians regarding choice of treatment modality (23).

Questionnaires exploring the value to prostate cancer patients and their partners of relationship, -nongenital sexuality (exchange of caresses) and genital sexuality (sexual intercourse) demonstrated that only importance of genital sexuality decreased in both partners before and after radical prostatectomy. Relationship and the importance of physical closeness (kissing and cuddling) retained their importance (24). Other studies confirmed this higher value placed on the fulfilment of the need for psychosocial closeness, intimacy, and security in comparison with the pursuit of purely sexual satisfaction (25).

Beier and Loewit’s (2004) method of couples therapy focuses on basic psychosocial needs (16). In this it differs from all other forms of treatment (Table 4 gif ppt). The primary aim of therapy is not to restore sexual function but to broaden the understanding of sexuality (relationship dimension), to enable new experiences of (sexual) physical communication, and to improve the (sexual) satisfaction within the overall relationship. Effective medication and mechanical aids are is by no means contraindicated but is on the contrary complementary, used at the right moment.

Case report
A 59 year old man presents to the sexual medicine clinic with his partner with persistent erectile dysfunction despite regular use of a PDE 5 inhibitor following nerve sparing radical prostatectomy for prostate cancer. The couple is clearly frustrated with the “lack of effect.” Their distress is significant, and physical contact is occurring only rarely. The female partner is “sad,” the male partner is considering increasing the medication dose or reducing the dose interval. They are afraid of “hurting each other.” The subject of sexuality is avoided.

Questions about feelings surrounding the experience of cancer, the current state of the relationship and their sexuality, as well as earlier experiences break the silence. Sex has always been an important part of the relationship for both parties, even if to different degrees, with a clear delineation of roles. Following surgery, this has changed, with sex now being initiated sporadically by the female partner, with him appearing “resigned” in the face of his missing erection and she reporting feeling guilty at his “stroking her to orgasm.” Both experience considerable pressure in connection with “the pill,” and miss moments of sexual contact such as they used to enjoy. In ten hours of couples therapy the focus is placed on more conscious use of body language and its associated meaning. The key moment in treatment is the recognition for both partners that despite “incompleteness” (physical and emotional trauma related to the cancer) it is possible to go on attending to oneself and each other, and to experience value, closeness, and security. The couple achieves this by prescribing themselves a break in medication as well as “new experiences” focussing on physical contact and find this a positive and meaningful experience, leading to more conscious verbal and nonverbal communication. Increasingly, both partners are able to “let go,” their genital organs are reclaimed as organs of communication, orgasm loses its negative associations and is experienced as the expression of mutual desire and a sense of belonging, in which each feels addressed and sought out by the other (“...I feel relaxed, as though a burden was falling away from me, ...we lie close, emotionally and physically...”).

By means of the altered perspective on sexuality, the much desired sexual intercourse, which the couple sees as “a particularly intense form of closeness,“ becomes possible via the use of a vacuum pump without performance anxiety or fear of failure. The health giving benefits of sexuality are once again within reach.

Conclusions
A sexual history (if possible with the partner’s involvement) is centrally important in the diagnosis of sexual difficulties and must respect the multidimensionality and multifunctionality of human sexuality. Treatment draws on sexual medical and psychotherapeutic techniques as well as organic and pharmacological elements. Couples sex therapy focuses primarily on basic psychosocial needs, with the aim of improving satisfaction in the sexual relationship.

The physician’s engagement with the question of sexuality and its disorders requires not only understanding of the biopsychosocial context, but also a willingness and ability to reflect on one’s own sexuality. This is indispensable because of the requirement to be able to address in a frank and authentic manner a subject which connects with (the pyhsician's own) intimate experience. Similarly, the ability to address the question of one’s own basic psychosocial needs is essential in order to help patients or couples address their own. This way of thinking and working is unfamiliar to many doctors, because, as sexual medicine remains untaught in a majority of undergraduate medical courses in Germany (20, e10) and elsewhere, it has never been learned. It is however teachable and learnable. In 1997 the Academy of Sexual Medicine for Doctors and Psychologists began its first two year, curriculum-based subspecialty training seminar at the Institute of Sexual Sciences and Sexual Medicine of the Charité Hospital, Berlin. The seminar has run continuously ever since (e9).

The ubiquitous human desire for the fulfilment of basic psychosocial needs is fundamental, and must be taken as seriously by medicine as the investigation of pathogenetic mechanisms. In relation to sexual dysfunction, this implies the restoration to patients of the health promoting effects of sexuality.

Although efforts are being directed at conducting controlled, clinical trials and randomized controlled multicentre studies in sexual medical research, it is an unfortunate truth that nowhere near such generous resources are available for this area as for that of commercially exploitable pharmaceutical research. But this must not lead, for ethical reasons, to the withholding from patients plausible and clinically tried and tested treatments.

Future perspectives
The Medical Association of the German Federal State of Berlin (Berliner Landesärztekammer) included the urgently needed special skills module ”Sexual Medicine“ in its Continuing Medical Education -curriculum. It is to be hoped that the Medical Associations of other German federal states as well as the German Medical Association will follow this example. This is important both for doctors and patients in search of qualified service provision in this area.

Conflict of interest statement
The authors declare no conflict of interests in the terms of the guidelines of the International Committee of Medical Journal Editors.

Manuscript submitted on 30 July 2008, revised version accepted on 8 April 2009.

Translated from the original German by Dr. Sandra Goldbeck-Wood.


Corresponding author
Dr. med. Dirk Rösing
Universitätsklinikum Greifswald
Anstalt öffentlichen Rechts
Klinik und Poliklinik für Urologie
Fleischmannstr. 42–44
17475 Greifswald, Germany
roesing@uni-greifswald.de

@For e-references please refer to:
www.aerzteblatt-international.de/ref5009

* Translator´s footnote:
The translation of terms referring to sexual therapies is complicated by non-equivalence in the precise nature of treatments and practitioners between countries. The German term „Sexualmedizin“ is translated in this article as „sexual medicine.“ However, this term implies treatment delivered in a healthcare setting which is both medical and psychological.
1.
Ahlers CJ, Schaefer GA, Beier KM: Das Spektrum der Sexualstörungen und ihre Klassifizierbarkeit im ICD-10 und DSM-IV. Sexuologie 2006; 12: 120–52.
2.
Laumann EO, Paik A, Rosen RC: Sexual dysfunction in the United States: prevalence and predictors. JAMA 1999; 281: 537–44. MEDLINE
3.
Rosen RC, Seidman SN, Menza MA, et al.: Quality of life, mood, and sexual function: a path analytic model of treatment effects in men with erectile dysfunction and depressive symptoms. Int J Impot Res 2004; 16: 334–40. MEDLINE
4.
Chevret M, Jaudinot E, Sullivan K, Marrel A, De Gendre AS: Impact of erectile dysfunction (ED) on sexual life of female partners: assessment with the Index of Sexual Life (ISL) questionnaire. J Sex Med 2004; 5: 595–601. MEDLINE
5.
Fisher WA, Rosen RC, Eardley I, Sand M, Goldstein I: Sexual experience of female partners of men with erectile dysfunction: the female experience of men’s attitudes to life events and sexuality (FEMALES) study. J Sex Med 2005; 2: 675–84. MEDLINE
6.
Abraham L, Symonds T, Morris MF: Psychometric validation of a sexual quality of life questionnaire for use in men with premature ejaculation or erectile dysfunction. J Sex Med 2008; 5: 595–601. MEDLINE
7.
Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB: Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol 1994; 151: 54–61. MEDLINE
8.
Braun M, Wassmer G, Klotz T, Reifenrath B, Mathers M, Engelmann U: Epidemiology of erectile dysfunction: results of the Cologne Male Survey. Int J Impot Res 2000; 12: 305–11. MEDLINE
9.
Chew KK, Bremner A, Jamrozik K, Earle C, Stuckey B: Male erectile dysfunction and cardiovascular disease: is there an intimate nexus? J Sex Med 2008; 5: 928–34. MEDLINE
10.
Mathers MJ, Schmitges J, Klotz T, Sommer F: Einführung in die Diagnostik und Therapie der Ejakulatio praecox. Dtsch Arztebl 2007; 104(50): A 3475–80.
11.
Althof SE: Prevalence, characteristics, and implications of premature ejaculation/rapid ejaculation. J Urol 2006; 175: 842–8. MEDLINE
12.
Rosen RC, Riley A, Wagner G, Osterloh I, Kirkpatrick J, Mishra A: The international Index of Erectile Function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997; 49: 822–30. MEDLINE
13.
Bloch W, Klotz T, Sedlaczek P, Zumbé J, Engelmann U, Addicks K: Evidence for the involvement of endothelial nitric oxide synthase from smooth muscle cells in the erectile function of the human corpus cavernosum. Urol Res 1998; 26: 129–35. MEDLINE
14.
Lue TF, Giuliano F, Montorsi F et al.: Summary of the recommen-dations on sexual dysfunctions in men. J Sex Med 2004; 1: 6–23. MEDLINE
15.
Beier KM, Bosinski HAG, Loewit K: Sexualmedizin. München, Jena: Urban & Fischer 2005; 2. Auflage.
16.
Beier KM, Loewit K: Lust in Beziehung – Einführung in die syndyastische Sexualtherapie. Berlin-Heidelberg: Springer 2004.
17.
Domes G, Heinrichs M, Michel A, Berger Ch, Herpertz SC: Oxytocin improves “mind reading” in humans. Biol Psychiatry 2007; 61: 731–3. MEDLINE
18.
Bartels A: Neuronale Grundlagen der Partnerwahl und der Liebe. Sexuologie 2006; 13: 118–29.
19.
Kleinplatz PJ, Ménard AD: Building blocks toward optimal sexuality: constructing a conceptual model. The Family Journal: Counseling and therapy for couples and families 2007; 15: 72–8.
20.
Beier KM, Ahlers CJ, Pauls A: Sexualmedizin als Bestandteil der Lehre im Medizinstudium. Sexuologie 2004; 11: 107–18.
21.
Schäfer GA, Engert HS, Ahlers ChJ, Roll S, Willich SN, Beier KM: Erektionsstörungen und Lebensqualität: Erste Ergebnisse der Berliner Männer-Studie. Sexuologie 2003; 10: 50–60.
22.
Bosinski HAG: Diagnostik und Therapie sexueller Störungen. Urologe [A] 2004; 43: 279–84. MEDLINE
23.
Herkommer K, Niespodziany S, Zorn C, Geschwend JE, Volkmer BG: Versorgung der erektilen Dysfunktion nach radikaler Prostatektomie in Deutschland. Urologe 2006; 45: 336–42. MEDLINE
24.
Rösing D, Berberich HJ: Krankheits- und behandlungsbedingte Sexualstörungen nach radikaler Prostatektomie – Eine bio-psycho-soziale Betrachtung. Urologe [A] 2004; 43: 291–5. MEDLINE
25.
Deneke FW: Psychische Struktur und Gehirn: die Gestaltung subjektiver Wirklichkeiten. Stuttgart; New York: Schattauer 1999.
e1.
Laumann EO, Nicolosi A, Glasser DB et al.: Sexual problems among women and men aged 40–80 y: prevalence and correlates identified in the Global Study of Sexual Attitudes and Behaviors. Int J Impot Res 2005; 17: 39–57. MEDLINE
e2.
Görge G, Flüchter S, Kirstein M, Kunz T: Sexualität, erektile Dysfunktion und das Herz: Ein zunehmendes Problem. Herz 2003; 28: 284–90. MEDLINE
e3.
Porst H, Montorsi F, Rosen RC, Gaynor L, Grupe S, Alexander J: The Premature Ejaculation Prevalence and Attitudes (PEPA) survey: prevalence, comorbidities, and professional help-seeking. Eur Urol 2007; 51:816–23. MEDLINE
e4.
Montorsi F: Prevalence of premature ejaculation: a global and regional perspective. J Sex Med 2005; 2 Suppl 2: 96–102. MEDLINE
e5.
Rosen RC, Cappellari JC, Smith MD, Lipsky J, Pena BM: Development and evaluation of an abridged, 5-item version of International Index of Erectile Dysfunction. Int J Impot Res 1999; 11: 319–26. MEDLINE
e6.
Jünemann KP: Wie wirksam sind die PDE-5-Hemmstoffe? Urologe[A] 2003; 42: 553–8. MEDLINE
e7.
Schaefer GA, Ahlers CJ: Differenzialdiagnostische Diskussion der Erektionsstörung. Urologe 2006; 45: 967–74. MEDLINE
e8.
Loewit K: Psychovegetative Beschwerden, depressive Verstimmung, nervöse Unruhe – liegt es an der unerfüllten Beziehung? MMW Fortschr Med 2008; 8: 31–4.
e9.
Beier KM: Sexualmedizin: Berufsbegleitende Fortbildung mit Zertifikat. Dtsch Arztebl 1999; 96(33): A2075–7.
e10.
Rösing D, Zimmermann U, Gillner M, Puttlitz FM, Rösing K, Klebingat KJ: Curriculum Sexualmedizin an der Universität Greifswald. GMS Z Med Ausbild 2007; 24: 106.
e11.
Rösing D, Klebingat KJ, Beier KM: Sexualtherapie bei sexuellen Funktionsstörungen des Mannes. Urologe 2006; 45: 975–80. MEDLINE
e12.
Ludwig G, Porst H, Wetterauer U, Sperling H, Hartmann U: Erektile Dysfunktion. Urologe 2006; 45: 157–62. MEDLINE
e13.
Hartmann U, Rüffer-Hesse C: Sexualität und Pharmakotherapie. Bundesgesundheitsbl-Gesundheitsforsch-Gesundheitsschutz 2007; 50: 19–32. MEDLINE
e14.
Stief CG, Truss MC, Becker AJ, Kuczyk M, Jonas U: Pharmakologische Therapiemöglichkeiten der Erektionsstörung. Dtsch Arztebl 2000; 97(8): A457–60.
e15.
Montagu A: Körperkontakt. Stuttgart: Klett-Cotta 1987: 134.
e16.
Arzneimittelkommission der deutschen Ärzteschaft: Stellenwert von Antidepressiva in der Depressionsbehandlung. AKDÄ Newsletter 2008 vom 17. April 2008.
e17.
Schiefenhövel W, Uher J, Krell R: Eibl-Eibesfeldt. Sein Schlüssel zur Verhaltensforschung. München: Langen Müller 1993: 78.

 Date HTM PDF 
8 / 2014 25 2
7 / 2014 15 3
6 / 2014 5 1
5 / 2014 3 0
4 / 2014 3 1
3 / 2014 8 3
2014 67 11
2013 118 41
2012 23 37
2011 78 52
2010 648 204
2009 197 62
Total 1.131 407

Letters to the Editor

All Letters