DEUTSCHES ÄRZTEBLATT INTERNATIONAL is a peer-reviewed, weekly, open-access, internet journal of medicine and public health. It is the international (English) version of the science section of Deutsches Ärzteblatt, the official journal of the German Medical Association (Bundesärztekammer) and the National Association of Statutory Health Insurance Physicians (Kassenärztliche Bundesvereinigung).

CHIEF SCIENTIFIC EDITOR: Prof. Dr. Christopher Baethge

DEPUTY SCIENTIFIC EDITOR: Prof. Dr. Dr. Remschmidt, Marburg, Child and Adolescent Psychiatry

Prof. Dr. Gerhard Adam, Hamburg, Radiology
Prof. Dr. med. Wolf Bechstein, Frankfurt am Main, General, Gastroenterological and Tranplantation Surgery
Prof. Dr. Friedhelm Beyersdorf, Freiburg, Cardiac and Vascular Surgery
Prof. Dr. Maria Blettner, Mainz, Epidemiology and Statisitics
Prof. Dr. Volker Budach, Berlin, Radiation Oncology and Radiotherapy
Prof. Dr. Ingolf Cascorbi, Kiel, Pharmacology
Prof. Dr. Marianne Dieterich, München, Neurology
Prof. Dr. Peer Eysel, Köln, Orthopedics
Prof. Dr. Klaus Friese, München, Obstetrics and Gynecology
Prof. Dr. Andreas Heinz, Berlin, Psychiatry
Prof. Dr. Ulrich Keilholz, Berlin, Oncology
Prof. Dr. Thea Koch, Dresden, Anesthesiology and Intensive Care Medicine
Prof. Dr. Dieter Leyk, Cologne/Koblenz, Sports Medicine
Prof. Dr. Wolf-Dieter Ludwig, Berlin, Hematology, Pharmacology
Prof. Dr. Joachim Mössner, Leipzig, Gastroenterology
Prof. Dr. Markus M. Nöthen, Bonn, Genetics
Prof. Dr. Dennis Nowak, München, Occupational Medicine
Prof. Dr. Georg Peters, Münster, Microbiology, Hygiene
Prof. Dr. Thomas Reinhard, Freiburg, Ophthamology
Prof. Dr. Markus A. Rothschild, Köln, Forensic Medicine
Prof. Dr. Herbert Rübben, Essen, Urology
Prof. Dr. Antonius Schneider, München, Primary Care Medicine
Prof. Dr. Andrea Tannapfel, Bochum, Pathology
Prof. Dr. med. Hans-Joachim Trappe, Bochum, Cardiology
Prof. Dr. Tobias Welte, Hannover, Pneumology
Prof. Dr. Hans-Peter Zenner, Tübingen, Otolaryngology
Prof. Dr. Josef Zentner, Freiburg, Neurosurgery
Prof. Dr. Detlef Zillikens, Lübeck, Dermatology
Prof. Dr. Klaus-Peter Zimmer, Gießen, Pediatrics 

EDITOR-IN-CHIEF, Deutsches Ärzteblatt: Egbert Maibach-Nagel, responsible in law for overall editorial content

EDITORIAL STAFF: Elke Bartholomäus M.A., Dr. Sandra Goldbeck-Wood, Catrin Marx, Dr. sc. nat. Stephan Mertens, Dipl.-Biol. Gabriele Seger, Dr. Marc Meißner

PRODUCTION DEPARTMENT: Herbert Moll (chief), Ralf Brunner, Michael Peters


ADDRESS OF THE EDITORIAL OFFICES: Ottostraße 12, 50859 Cologne, Germany; P.O. Box 40 02 43, 50832 Cologne, Germany; phone: +49 (0) 22 34/70 11-1 20; fax: +49 (0) 22 34/70 11-1 42; email:;

The instructions for authors are available at:

Articles appearing in DEUTSCHES ÄRZTEBLATT INTERNATIONAL are indexed in the following databases: Carelit, CINAHL, Compendex, DOAJ, EMBASE, EMNursing, GEOBASE, HINARI, Index Copernicus, Medline, Medpilot, PsycINFO, Science Citation Index expanded and Scopus.

Articles represent the views of authors and not necessarily those of the editorial team. Any quoted dosages, indications or applications of treatments, particularly in the case of newly licensed products, must be checked against information supplied by the manufacturer.
DEUTSCHES ÄRZTEBLATT INTERNATIONAL reserves all rights, in particular the right to reproduce, microcopy, save to electronic databases, or translate into other languages, material published therein. Reprints and inclusion in electronic databases is permitted, whether wholly or in part, only with the permission of the publisher. We cannot guarantee to return unsolicited, submitted manuscripts. Submission of material to the editorial team implies agreement to its full or partial publication unless wishes to the contrary are clearly expressed at the time of submission.

CHIEF EXECUTIVE OFFICERS DEUTSCHER ÄRZTE-VERLAG GMBH: Norbert A. Froitzheim (publisher), Jürgen Führer


PUBLISHER: Deutscher Ärzte-Verlag GmbH, Dieselstraße 2, 50859 Cologne, Germany; P.O. Box 40 02 54, 50832 Cologne, Germany; phone: +49 (0) 22 34/70 11-0; fax: +49 (0) 22 34/70 11-4 60,; email:

TAX REFERENCE: USt. IdNr. DE 123474208

PRODUCTION: L. N. Schaffrath DigitalMedien GmbH, Geldern

ISSN 1866-0452