Competitive Sports and the Heart
Benefit or Risk?
Background: Controversy surrounds the cardiac effects of competitive sports and the athlete’s heart. In this review, we present and discuss the main cardiological findings in competitive athletes.
Method: Selective review of pertinent literature retrieved by a search with the keywords “athlete’s heart,” “ECG,” “echocardiography,” “endurance exercise,” “longevity,” and others.
Results: Regular exercise leads to functional and structural adaptations that improve cardiac function. Athlete’s heart, which develops rarely, is a typical finding in endurance athletes. This condition is characterized by physiological, harmonically eccentric hypertrophy of all cardiac chambers. The athlete’s ECG can be used to distinguish physiological, training-related changes from pathological training-unrelated changes. The athlete’s heart function is normal at rest and increases appropriately during exercise. The cardiac markers troponin and B-type natriuretic peptide are within the normal range in healthy athletes at rest, but can temporarily be mildly elevated after exhausting endurance-exercise, without evidence of myocardial damage. The epidemiological data suggest that participation in competitive sports increases life expectancy.
Conclusion: Competitive exercise does not induce cardiac damage in individuals with healthy hearts, but does induce physiological functional and structural cardiac adaptations which have positive effects on life expectancy.
Physicians of the ancient and early modern world often recommended physical exercise as a means of staying healthy. Today, various medical specialty societies recommend exercise and athletic activity to maintain and preserve health, on the basis of strong evidence from numerous single studies and meta-analyses (1). On the other hand, ever since the “athlete’s heart” was described more than 100 years ago (e1), there has been concern that prolonged and intense athletic activity might confer certain risks, while exercise-induced cardiac changes have been interpreted as a potential sign of damage (e2, e3). The question whether sport has a net positive or negative effect on health was already debated in 1912 at the first sports-medicine conference in Germany (e4). Among physicians, those with no special training or experience in sports medicine tend to view athlete’s heart as a potentially dangerous condition and to think that the associated cardiac enlargement and ECG changes indicate an increased cardiac risk. Reindell et al. (2), and later Kindermann (3), interpreted the radiological, electrocardiographic, and hemodynamic changes seen in healthy athletes as physiological adaptations of the heart; yet the recurring reports of cardiac events, and even sudden cardiac death, among athletes (4, e5) continue to sustain the debate over the potential pathological effects of sports on the heart, rare as they may be (e6).
We critically review the current evidence about the risks and benefits of athletic activity and describe the proper classification of cardiac findings in competitive athletes from the point of view of the sports cardiologist. Readers should become well informed about the following matters:
- physiological cardiovascular adaptations,
- ECG changes,
- structural and functional findings of imaging studies,
- stress-induced elevation of the concentrations of the cardiac markers troponin and BNP,
- and the life span of competitive athletes.
We selectively searched the PubMed database for articles published up to June 2012 that contained the keywords “athletes,” “athlete’s heart,” “BNP,” “ECG,” “echocardiography,” “electrocardiography,” “endurance exercise,” “magnetic resonance imaging,” “MRI,” “NT-proBNP,” “troponin,” “longevity,” and others. We present their most important findings in this article. The recommendations given here regarding ECG interpretation in patients who participate in sports correspond to the current criteria of the European Society of Cardiology (5).
Physiological cardiovascular changes
Oxygen uptake rises by a factor of 10 to 12 during exercise in healthy, untrained individuals and by a factor of 20 or more in highly trained endurance athletes (e7). This rise is accounted for by increases in cardiac output and in the arteriovenous oxygen concentration gradient. The increased cardiac output is mainly due to a faster heart rate; as a rule of thumb, the maximum attainable number of beats per minute can be estimated as 220 minus the age in years. The increased heart rate is caused initially by a drop in parasympathetic activity, and then, during intermediate or intense exercise, by an increase in sympathetic activity. The stroke volume increases by only 30% to 50%.
Dynamic exercise causes a rise in systolic blood pressure that is linearly related to exercise intensity, while the diastolic pressure is only marginally changed. On the other hand, static exercise—in particular, maximal exertion—or high-intensity dynamic exercise or Valsalva maneuvers causes a much greater rise in both systolic and diastolic blood pressure (e8). The pressures in the pulmonary artery and in the heart itself rise only slightly during exercise and remain in the normal range even under exercise stress (Figure 1) (3, e9). In general, dynamic exercise mainly increases the heart’s volume load, while static stress mainly increases its pressure work (e10).
Cardiovascular adaptation differs depending on the type of physical exercise and on the extent and intensity of training. Functional adaptations appear within a few weeks, requiring an additional energy consumption of at least 500 to 1000 kcal per week (6, e11, e12), which corresponds, for example, to brisk walking for one hour two to three times a week. Aerobic training lowers the heart rate and increases stroke volume without changing cardiac output at rest or for a given exercise intensity representing an economization of cardiac function (e13). Maximal cardiac output rises because the heart-rate reserve capacity increases while the maximal heart rate remains constant. The stroke volume is greater because of improved filling dynamics of the left ventricle, including greater compliance (e9, e14) and reduced peripheral vascular resistance (e15), so that the end-diastolic volume rises and the end-systolic volume falls. Increased shear stress during exercise improves endothelial function, with secretion of vasodilatory substances (e16).
Training beyond a certain level (which differs from one individual to another) leads to structural adaptations as well. These dimensional changes of the heart are known as athlete’s heart; they generally arise only after endurance training in an amount that is generally only undertaken by competitive athletes. All chambers of the heart become dilated and hypertrophic. This eccentric hypertrophy is a harmonic enlargement of the heart (7) in which the heart mass does not exceed the critical value of 7.5 g/kg, corresponding on average to 500 g. In some cases, an athlete’s heart can be nearly twice as big as that of an untrained, healthy person (e17, e18).
Athlete’s heart is rarer than generally thought and is not a prerequisite for a beneficial effect of training on health. At least five hours of endurance training per week, and more in many cases, are necessary for the volume load to result in dimensional changes (e19). The amount is highly variable: Running 60–70 km per week leads to the development of athlete’s heart in some persons, while others do not develop it even if they run 100 km per week. Athlete’s heart appears most prominent in long-distance runners, road bicycle racers, cross-country skiers, and triathletes. Athlete's heart may also develop in older endurance athletes. On the other hand, strength and speed athletes, such as weightlifters, gymnasts, sprinters, high-jumpers, discus- and javelin-throwers, or Alpine skiers, generally do not develop athlete’s heart (Figure 2). The so-called strength athlete's heart, which—in contrast with the eccentric hypertrophy characteristic of endurance athlete's heart—shows concentric hypertrophy (8, e20), is discussed in the literature, not primarily in connection with exercise-related cardiac load, but more frequently in connection with the abuse of anabolic steroids and other performance-enhancing drugs (9, 10, e21). Pulmonary-arterial pressure and intracardiac pressure is not elevated in athlete’s heart (Figure 1) (3).
When training ceases, an athlete's heart size reduces again (e22, e23), with individually variable rates of regression. Immobilization (e.g., bed rest) leads to rapid regression of heart size (2). Athlete’s heart often regresses incompletely, however, with persistent left ventricular enlargement despite normalization of chamber thickness (e13, e23). Incomplete regression is thought to be due to genetic factors combined with continued athletic activity at a lower level than before. An important point for clinical practice is that, as long as there is still some degree of cardiac enlargement from athlete’s heart, the individual will still have a higher than average ergometric performance capacity for age.
ECG changes in athletes
Various authors have reported ECG changes in athletes and have attempted to distinguish them from pathological findings (2, 5, 11, 12, e25–e27). There is, however, a gray zone between physiological and pathological changes. Depending on the particular study and method of classification used, 5% to 40% of athletes are found to have an abnormal or moderately to distinctly abnormal ECG (e25, e28, e29). Even higher percentages of abnormal findings have been found in selected groups of highly trained athletes, and only a small fraction of these persons (ca. 5%) have structural heart disease unrelated to their athletic activity (e25). The necessary distinction between common, training-related ECG changes and uncommon, training-unrelated ones that may be pathological should be drawn according to the current criteria and recommendations (Box) (5, e27). Hence, false-positive findings can be markedly reduced, and specificity increased without loss of sensitivity (11, e28), compared to earlier recommendations (12). Uncommon ECG changes are more frequent in men than in women, and they are also more frequent in black athletes, and require further evaluation (13, e29, e30).
ECG changes are most commonly seen in endurance athletes (e25). Sinus arrhythmia and sinus bradycardia are very common : on Holter monitoring, the heart rate may be found to dip as low as 30 beats per minute, or rarely even lower, usually at night. First-degree AV block (asymptomatic; resolves under stress) and second-degree AV block of Mobitz type I (Wenckebach block) are often seen in athletes, but second-degree AV block of Mobitz type II and third-degree AV block are atypical and require further evaluation.
Occasional ventricular and supraventricular extrasystoles are seen in athletes as well and are of no significance as long as they are asymptomatic. Frequent extrasystoles (more than 2000 in 24 hours on Holter monitoring [e31]) and paroxysmal supraventricular tachycardia require evaluation. Any arrhythmia that worsens during exercise must be evaluated; in athletes with a very low basal heart rate, extrasystoles usually disappear during exercise as sympathetic activity increases. In unclear cases, ambulatory ECG monitoring—ideally including the performance of usual athletic activities—should be performed to rule out significant arrhythmias.
Atrial fibrillation is more common among middle-aged and older endurance athletes who have been training for many years than it is among athletically inactive persons of the same age (for elderly persons, 23% versus 12.5%) (14). The proposed pathophysiological mechanisms involve altered autonomic regulation due to athletic training, leading to a more intense vagal reaction, often at night; a lesser degree of sympathetic stimulation; and atrial remodeling. Endurance athletes aged 20 to 30 do not have atrial fibrillation any more commonly than non-athletes (e32). On the other hand, it has been found that moderate endurance training, as performed in preventive-fitness programs, may actually lower the risk of atrial fibrillation in old age (e33).
Alterations in the QRS complex and during repolarization are also more commonly seen in athletes and are usually physiological. 35% to 50% of athletes have an incomplete right bundle branch block; endurance athletes are the most likely to exhibit this finding (5). In contrast, complete right or left bundle branch block is not due to athletic activity and requires further evaluation. Isolated QRS voltage elevations should not be taken as an indicator of hypertrophy among athletes.
50% to 80% of all highly-trained athletes present with early repolarization, which is reflected in the ECG by elevation of the beginning of the ST segment (by at least 0.1 mV at the J point), usually seen in leads V2 through V4. The ST segment is then either concave (the typical finding in white athletes) or convex (the typical finding in black athletes). Moreover, as many as 25% of healthy black athletes with ST-segment elevation may also have negative T waves (5). The latter repolarization abnormality, which is more common in both male and female black athletes than in white athletes (13, e29, e30), may represent an ethnic variant of athlete’s heart (e31). Negative T waves that are at least 2 mm deep and are seen in two or more adjacent leads (frequency among athletes, ca. 3%) and ST-segment depressions require further evaluation (5, e25).
The QT interval is generally somewhat longer in athletes because of their lower heart rate. When correcting the QT interval for the lower rate, one must bear in mind that the correction is imprecise for rates under 40 beats per minute or over 80–100 beats per minute. A QTc of 500 ms or above is considered unequivocally pathological, while the range from 440 to 500 ms (in men) or from 460 to 500 ms (in women) is considered a gray zone (5).
Findings of imaging studies
The most important routine method for differentiating physiological from pathological cardiac hypertrophy is echocardiography, which can also be used to determine cardiac volume (e34, e35). The normal cardiac volume depends on body weight and lies in the range of 10–12 mL/kg in men and 9–11 mL/kg in women (Figures 1 and 2) (e36). Athlete’s heart is defined as a heart volume ≥12 mL/kg body weight in women and 13 mL/kg body weight in men, up to a maximum of 19 and 20 mL/kg, respectively. The end-diastolic diameter of the left ventricle is enlarged in an athlete’s heart (60 mm or more in 15% of athletes), while the left ventricular wall thicknesses are normal or in the upper portion of the normal range (13–15 mm in 2% to 4% of athletes) (Table 1) (15, 16). The left ventricular wall may be 1 or 2 mm thicker in black athletes (15). The clinical relevance of these findings remains unclear. The relative wall thickness, defined as the ratio of left ventricular thickness to end-diastolic inner diameter, normally does not exceed 42–43% in athletes (Figure 3) (10, e37). The left artrium is enlarged in 20% of athletes, with maximum values of 50 mm (men) and 45 mm (women) (e32) (Table 1). Physiological atrial remodeling is closely related to left ventricular dilatation; thus, left atrial enlargement is mainly seen in endurance athletes and strength-endurance athletes (e.g., rowers, canoeists) (e32).
In healthy athletes, systolic function is normal at rest. For those with athlete’s heart, it may be in the low-normal range or even slightly below it, while the stroke volume remains normal (7, 10, e24, e36). Stress echo-cardiography reveals a normal increase in systolic function (10). Diastolic function is normal or in the high-normal range (10, e38). Depending on the type of study and the particular variables measured, regional systolic and diastolic left and right ventricular myocardial function, which can be visualized on the basis of myocardial deformation with tissue Doppler and with two- and three-dimensional speckle tracking (Figure 4), are found to lie in the low- to high-normal range; the same is true of left and right atrial function (e38–e49).
Echocardiography has often been performed before and immediately after exhausting endurance exercise, or endurance competitions, to determine whether there has been any acute exercise-induced damage to the heart (e50–e52). Such studies generally reveal a mild reduction of diastolic function, and sometimes of systolic function as well, which some authors have called “cardiac fatigue” (e50–e53). However, the validity of such comparisons is limited by the different physiological conditions that prevail before and after exercise (e.g., differences in plasma volume, heart rate, or blood pressure). Prolonged endurance exercise may acutely impair right ventricular function more than left ventricular function (17, 18, e54). In general, the echocardiographically demonstrable acute exercise-induced functional changes in healthy athletes are only transient; unlike those seen in persons with heart disease, they are mild and apparently clinically insignificant (e51, e52, e55).
Cardiac magnetic resonance imaging (MRI)
The biventricular, eccentric cardiac hypertrophy characteristic of athlete’s heart, which Reindell originally described on the basis of conventional diagnostic x-rays (2), has been confirmed by cardiac magnetic imaging (MRI) and shown to consist of balanced hypertrophy of the left and right ventricle (7). In strength athletes who do not take anabolic drugs, MRI (like echocardiography) does not reveal concentric hypertrophy of either ventricle (e56, e57). The reported figures for left and right ventricular volume and myocardial mass in athletes cover a wide range because of the widely differing groups of individuals studied and measuring techniques used. These volumes and masses are, however, well correlated with maximal oxygen uptake (VO2max) (7, e58); spiroergometry is, therefore, recommended in unclear cases for an objective assessment of endurance capacity. In this context, it has to be remembered that MRI generally yields higher values than echocardiography for the atrial and ventricular dimensions and lower values for wall thicknesses and muscle masses (19).
45% is considered the lower reference limit of normal for the left and right ventricular systolic ejection fraction in athletes, as measured by MRI (e59). Lower values may be physiological in some cases, particularly in endurance athletes with athlete’s heart.
Exercise-induced increases in the concentrations of the cardiac biomarkers troponin I and T (TnI, TnT) and B-type natriuretic peptide (BNP and N-terminal proBNP [NT-proBNP]) have been extensively studied in the last decade and a half (20, 21). In non-athletes, these biomarkers are found at pathologically high levels only after myocardial infarction or in congestive heart failure.
A meta-analysis of studies involving a total of more than 1000 endurance athletes showed that 47% had an elevation of third-generation TnT concentration beyond the upper reference limit of normal after exhausting endurance exercise (e.g., a marathon or triathlon) (e60). In studies that showed a percentage of TnT-positive athletes in this range, the percentage of TnI-positive athletes was even higher, ca. 75% to 80% (e61–e63). More recent studies employing high-sensitivity troponin tests have revealed comparable or even higher percentages of troponin-positive athletes after exhausting endurance exercise (e62, e63). Presumably, nearly all athletes engaging in such activities have a transient, reversible increase in troponin concentration.
In myocardial infarction, the troponin concentration increases when bound troponin is released from the tropomyosin complex of necrotic cardiomyocytes. In contrast, the elevation of troponin concentration in athletes is attributed to the release of unbound troponin from the cytoplasmic pool by membrane vesicles, without cell necrosis (20, 21, e64). How this comes about is currently unknown. The putative mechanisms include changes of intracellular metabolism, changes of intracellular calcium concentration that activate intracellular proteases, free-radical effects, and exercise-induced ischemia (20, 21, e51, e55). Further experimental studies are needed to clarify the matter.
BNP and NT-proBNP
BNP and NT-proBNP also rise, particularly after exhausting endurance activities. The percentage of athletes with elevated concentrations of these biomarkers after such activity is in the same range as that mentioned above for troponin. Well-trained marathon runners or those with high training volumes seem to have lower increases of BNP and NT-proBNP concentrations, as well as lower increases of troponin concentration, than less well-trained marathon runners do (17). The elevation of BNP-/NT-proBNP, unlike that of troponin, is affected by the duration of exercise, not just by its intensity (e37).
Compared to healthy, but athletically untrained persons of like age, athletes with or without athlete's heart do not have elevated BNP-/NT-proBNP concentrations at rest (20, e66–e68), nor do these concentrations rise to any greater degree than in untrained persons in response to standardized exercise, despite greater ergometric and cardiac performance (e69). The recently reported moderate association between exercise-induced elevation of the BNP or TnI concentration amd transient right ventricular dysfunction after prolonged endurance stress may indicate that endurance exercise has a stronger effect on the right ventricle (17, 18).
The important point for clinical practice with respect to exercise-induced elevation of troponin and BNP-/NT-proBNP concentrations is that a majority of athletes may have a transient elevation after exhausting endurance exercise in the absence of any pathological abnormality. In healthy athletes, the troponin values usually decline markedly within 24 hours and reach normal limits within 24 to 48 hours (at most, 72 hours). Doubtful cases with unclear findings require further cardiological evaluation.
The life expectancy of competitive athletes
The benefits and risks of competitive sports can also be judged in terms of life expectancy . Although there is good evidence for a higher life expectancy among persons who regularly participate in recreational sports (1), there has always been concern that the much more intense, exhausting physical activity demanded of competitive and high-performance athletes might actually shorten their lives (22, e70). A recent review article (23) and editorial (e70) addressed this question by summarizing the findings of 14 (resp. 15) published studies: it was concluded that endurance athletes who achieve national and international success in sports such as long-distance running, cross-country skiing, and bicycle racing, as well as athletes in mixed types of sport, such as soccer, basketball, and ice hockey, have a longer life span than the general population. This, in turn, is largely due to lower cardiovascular mortality, particularly among athletes who continue endurance training even after they stop competing. Strength-based sports, on the other hand, seem not to prolong life (23).
Because of the recent debate over potential danger to the heart from extreme endurance sports, studies on elite endurance athletes whose extensive training and high performance make them likely to have an athlete’s heart (i.e., physiological cardiac remodeling) are presented separately in Table 2 (24, 25, e71, e72). One such study, recently published, is a retrospective assessment of 834 cyclists who took part in the Tour de France bicycle race from 1930 to 1964: 50% of them were still alive at age 82, while 50% of the general population born from 1892 to 1942 was already dead by age 74 (24). It remains an open question, however, whether endurance and high-performance exercise can still be as beneficial as this in the modern era, in which athletes’ life expectancy may be shortened by the cardiovascular and other side effects of doping drugs such as anabolic steroids, growth hormone, and erythropoietin (9, e73).
With respect to amateur endurance sports performed on a competitive level, a study of more than 73 000 participants in the Swedish Vasa cross-country ski race (over 30 and 90 km) from 1989 to 1998 revealed that only 410 of them had died by 1999, a much lower number than the 851 deaths that would have been expected in the general population, after adjustment for age (standardized mortality ratio [SMR] 0.48) (e74). The relative reduction of cardiovascular mortality among participants was 57% (SMR 0.43). In a Dutch study of 2129 men who skated in the single-day Eleven Cities Ice-Skating Tour (with a course of more than 200 km), the observed number of deaths in athletes from any cause over 32 years of observation was 24% lower than would have been expected for the general population (SMR 0.76) (e75).
Taken together, the foregoing epidemiological data imply that endurance sports prolong life even when they are pursued competitively. The athletes’ healthier lifestyle, with regular physical activity even when their sporting careers are over, is presumably decisive.
Regular athletic activity brings about functional adaptations that improve cardiac function. Athlete’s heart, which develops only after intensive training with a high endurance component, is not a pathological condition and is much rarer than commonly thought. An athlete’s ECG may well reveal certain common, training-related changes which must be distinguished from uncommon, training-unrelated ECG-changes that require further evaluation. The variables measured in cardiac imaging studies exceed the normal range for untrained individuals only in persons who have undergone competitive endurance training. Cardiac function in athlete’s heart is normal at rest and increases appropriately during exercise. The concentrations of the cardiac biomarkers troponin and BNP/NT-proBNP may rise transiently in healthy athletes in response to endurance exercise; this is not currently thought to represent exercise-induced damage to the heart. Epidemiological data show that endurance sports prolong life even when they are pursued at the competitive level.
Conflict of interest statement
The authors state that no conflict of interest exists.
Manuscript submitted on 12 July 2012, revised version accepted on 27 November 2012.
Translated from the original German by Ethan Taub, M.D.
PD Dr. med. Jürgen Scharhag
Innere Medizin III: Kardiologie, Angiologie und Pneumologie
Im Neuenheimer Feld 410
69120 Heidelberg, Germany
@For eReferences please refer to:
Internal Medicine, Cardiology and Sports Medicine Office, Remscheid: Prof. Dr. med. Löllgen
Institute of Sports and Preventive Medicine, Saarland University: Prof. em. Dr. med. Kindermann
|1.||Löllgen H, Löllgen D: Risikoreduktion kardiovaskulärer Erkrankungen durch körperliche Aktivität. Internist 2012; 53: 20–9. CrossRef MEDLINE|
|2.||Reindell H, Klepzig H, Steim H, Musshoff K, Roskamm H, Schildge E: Herz, Kreislaufkrankheiten und Sport. Barth, München 1960.|
|3.||Kindermann W, Keul J, Reindell H: Grundlagen zur Bewertung leistungsphysiologischer Anpassungsprozesse. Dtsch Med Wochenschr 1974; 99: 1372–9. CrossRef MEDLINE|
|4.||Maron BJ, Doerer JJ, Haas TS, Tierney DM, Mueller FO: Sudden deaths in young competitive athletes: analysis of 1866 deaths in the United States, 1980–2006. Circulation 2009; 119: 1085–92. CrossRef MEDLINE|
|5.||Corrado D, Pelliccia A, Heidbuchel H, et al.: Recommendations for interpretation of 12-lead electrocardiogram in the athlete. Eur Heart J 2010; 31: 243–59. CrossRef MEDLINE|
|6.||Paffenbarger RS, Hyde RT, Wing AL, Hsieh CC: Physical activity, all cause mortality, and longevity of college alumni. N Engl J Med 1986; 314: 605–13. CrossRef MEDLINE|
|7.||Scharhag J, Schneider G, Urhausen A, Rochette V, Kramann B, Kindermann W: Athlete’s heart: right and left ventricular mass and function in male endurance athletes and untrained individuals determined by magnetic resonance imaging. J Am Coll Cardiol 2002; 40: 1856–63. CrossRef MEDLINE|
|8.||Pluim BM, Zwinderman AH, van der Laarse A, van der Wall EE: The athlete’s heart. A meta-analysis of cardiac structure and function. Circulation 2000; 101: 336–44. CrossRef MEDLINE|
|9.||Kindermann W: Kardiovaskuläre Nebenwirkungen von anabol-androgenen Steroiden. Herz 2006; 31: 566–73. CrossRef MEDLINE|
|10.||Urhausen A, Kindermann W: Sports-specific adaptions and differentiation of the athlete`s heart. Sports Med 1999; 28: 237–44. CrossRef MEDLINE|
|11.||Baggish AL, Hutter AM, Wang F, et al.: Cardiovascular screening in college athletes with and without electrocardiography: A cross-sectional study. Ann Intern Med 2010; 152: 269–75. MEDLINE|
|12.||Pelliccia A, Fagard R, Bjørnstad HH, et al.: Recommendations for competitive sports participation in athletes with cardiovascular disease: a consensus document from the Study Group of Sports Cardiology of the Working Group of Cardiac Rehabilitation and Exercise Physiology and the Working Group of Myocardial and Pericardial Diseases of the European Society of Cardiology. Eur Heart J, 2005; 26: 1422–45. CrossRef MEDLINE|
|13.||Papadakis M, Carre F, Kervio G, et al.: The prevalence, distribution, and clinical outcomes of electrocardiographic repolarization patterns in male athletes of African/Afro-Caribbean origin. Eur Heart J 2011; 32: 2304–13. CrossRef MEDLINE|
|14.||Abdulla J, Nielsen JR: Is the risk of atrial fibrillation higher in athletes than in the general population? A systematic review and meta-analysis. Europace 2009; 11: 1156–9. CrossRef MEDLINE|
|15.||Basavarajaiah S, Boraita A, Whyte G, et al.: Ethnic differences in left ventricular remodeling in highly-trained athletes relevance to differentiating physiologic left ventricular hypertrophy from hypertrophic cardiomyopathy. J Am Coll Cardiol 2008; 51: 2256–62. CrossRef MEDLINE|
|16.||Pelliccia A, Maron BJ, Spataro A, Proschan MA, Spirito P: The upper limit of physiologic cardiac hypertrophy in highly trained elite athletes. N Eng J Med 1991; 324: 295–301. CrossRef MEDLINE|
|17.||Neilan TG, Januzzi JL, Lee-Lewandrowski E, et al.: Myocardial injury and ventricular dysfunction related to training levels among nonelite participants in the Boston marathon. Circulation 2006; 114: 2325–33. CrossRef MEDLINE|
|18.||La Gerche A, Burns AT, Mooney DJ, et al.: Exercise-induced right ventricular dysfunction and structural remodelling in endurance athletes. Eur Heart J 2012; 33: 998–1006. CrossRef MEDLINE|
|19.||Prakken NHJ, Teske AJ, Cramer MJ, et al.: Head-to-head comparison between echocardiography and cardiac MRI in the evaluation of the athlete’s heart. Br J Sports Med 2012; 46: 348–54. CrossRef MEDLINE|
|20.||Scharhag J, George K, Shave R, Urhausen A, Kindermann W: Exercise-associated increases in cardiac biomarkers. Med Sci Sports Exerc 2008; 40: 1408–15. CrossRef MEDLINE|
|21.||Shave R, Baggish A, George K, et al.: Exercise-Induced Cardiac Troponin Elevation: Evidence, Mechanisms, and Implications. J Am Coll Cardiol 2010; 56: 169–76. CrossRef MEDLINE|
|22.||Vina J, Sanchis-Gomar F, Martinez-Bello V, Gomez-Cabrera M: Exercise acts as a drug. Pharmacological benefits of exercise. Br J Pharmacol 2012; 167: 1–12. CrossRef MEDLINE|
|23.||Teramoto M, Bungum TJ: Mortality and longevity of elite athletes. J Sci Med Sport 2010; 13: 410–6. CrossRef MEDLINE|
|24.||Sanchis-Gomar F, Olaso-Gonzalez G, Corella D, Gomez-Cabrera MC, Vina J: Increased average longevity among the „Tour de France“ cyclists. Int J Sports Med 2011; 32: 644–7. CrossRef MEDLINE|
|25.||Sarna S, Sahi T, Koskenvuo M, Kaprio J: Increased life expectancy of world class male athletes. Med Sci Sports Exerc 1993; 25: 237–44. CrossRef MEDLINE|
|e1.||Henschen S: Skilanglauf und Skiwettkampf: Eine medizinische Sportstudie. Fischer, Jena 1899.|
|e2.||Löllgen H: Herz und Sport. Herz 2012; Epub ahead of print.|
|e3.||Rost R: The athlete’s heart. Historical perspectives. Cardiol Clin 1992; 10: 197–207.|
|e4.||Greiner E, Arndt K: Der erste deutsche Sportärztekongress 1912 – Programm für ein Jahrhundert. Dtsch Z Sportmed 2004; 55: 310–4.|
|e5.||Kim JH, Malhotra R, Chiampas G, et al.: Cardiac arrest during long-distance running races. N Engl J Med 2012; 366: 130–40. MEDLINE|
|e6.||Myerson M, Sanchez-Ross M, Sherrid MV: Preparticipation athletic screening for genetic heart disease. Prog Cardiovasc Dis 2012; 54: 543–52. MEDLINE|
|e7.||Hoppeler H, Weibel ER: Limits for oxygen and substrate transport in mammals. J Exp Biol 1998; 201: 1051–64. MEDLINE|
|e8.||MacDougall JD, Tuxen D, Sale DG, Moroz JR, Sutton JR: Arterial blood pressure response to heavy resistance exercise. J Appl Physiol 1985; 58: 785–90. MEDLINE|
|e9.||Stickland MK, Welsh RC, Petersen SR, et al.: Does fitness level modulate the cardiovascular hemodynamic response to exercise? J Appl Physiol 2006; 100: 1895–1901. MEDLINE|
|e10.||Friedman DB, Peel C, Mitchell JH: Cardiovascular responses to voluntary and nonvoluntary static exercise in humans. J Appl Physiol 1992; 73: 1982–5. MEDLINE|
|e11.||Lee IM, Paffenbarger RS Jr.: Associations of light, moderate, and vigorous intensity physical activity with longevity. The Harvard Alumni Health Study. Am J Epidemiol 2000; 151: 293–9. CrossRef MEDLINE|
|e12.||Paffenbarger RS Jr., Hyde RT, Wing AL, Lee IM, Jung DL, Kampert JB: The association of changes in physical-activity level and other lifestyle characteristics with mortality among men. N Engl J Med 1993; 328: 538–45. CrossRef MEDLINE|
|e13.||Keul J, Dickhuth H, Lehmann M, Staiger J: The athlete’s heart – haemodynamics and structure. Int J Sports Med 1982; 3: 33–43. MEDLINE|
|e14.||Levy WC, Cerqueira MD, Abrass IB, Schwartz RS, Stratton JR: Endurance exercise training augments diastolic filling at rest and during exercise in healthy young and older men. Circulation 1993; 88: 116–26. CrossRef MEDLINE|
|e15.||Snell PG, Martin WH, Buckey JC, Blomqvist CG: Maximal vascular leg conductance in trained and untrained men. J Appl Physiol 1987; 62: 606–10. MEDLINE|
|e16.||Di Francescomarino S, Sciartilli A, Di Valerio V, Di Baldassarre A, Gallina S: The effect of physical exercise on endothelial function. Sports Med 2009; 39: 797–812. MEDLINE|
|e17.||Rost R, Hollmann W: Athlete`s heart – a review of its historical assessment and new aspects. Int J Sports Med 1983; 4: 147–65. CrossRef MEDLINE|
|e18.||Urhausen A, Kindermann W: Echocardiographic findings in strength- and endurance-trained athletes. Sports Med 1992; 13: 270–84. CrossRef MEDLINE|
|e19.||Urhausen A, Kindermann W: Nichtinvasive Differentialdiagnostik vergrößerter Herzen bei Sporttreibenden. Dtsch Z Sportmed 1987; 38: 290–6.|
|e20.||Morganroth J, Maron BJ, Henry WL, Epstein SE: Comparative left ventricular dimensions in trained athletes. Ann Intern Med 1975; 82: 521–4. MEDLINE|
|e21.||Achar S, Rostamian A, Narayan SM: Cardiac and Metabolic Effects of Anabolic-Androgenic Steroid Abuse on Lipids, Blood Pressure, Left Ventricular Dimensions, and Rhythm. Am J Cardiol 2010; 106: 893–901. CrossRef MEDLINE|
|e22.||Dickhuth HH, Horstmann T, Staiger J, Reindell H, Keul J: The long-term evolution of physiological cardiomegaly and cardiac hypertrophy. Med Sci Sports Exerc 1989; 21: 244–9.CrossRef MEDLINE|
|e23.||Pelliccia A, Maron B, De Luca R, Di Paolo F, Spataro A, Culasso F: Remodeling of left ventricular hypertrophy in elite athletes after long-term deconditioning. Circulation 2002; 105: 944–9. CrossRef MEDLINE|
|e24.||Kindermann W: Physiologische Anpassungen des Herz-Kreislauf-Systems an körperliche Belastung. In: Kindermann W, Dickhuth HH, Niess A, Röcker K, Urhausen A (eds.): Sportkardiologie. 2nd Edition. Steinkopff Verlag Darmstadt 2007: 1–20. CrossRef|
|e25.||Pelliccia A, Maron BJ, Culasso F, et al.: Clinical significance of abnormal electrocardiographic patterns in trained athletes. Circulation 2000; 102: 278–84. CrossRef MEDLINE|
|e26.||Scharhag J: Das Sportler-EKG. Dtsch Z Sportmed 2007; 58: 184–5.|
|e27.||Uberoi A, Stein R, Perez MV, et al.: Interpretation of the Electrocardiogram of Young Athletes. Circulation 2011; 124: 746–57. CrossRef MEDLINE|
|e28.||Weiner RB, Hutter AM, Wang F, et al.: Performance of the 2010 European Society of Cardiology criteria for ECG interpretation in athletes. Heart 2011; 97: 1573–77. CrossRef MEDLINE|
|e29.||Wilson MG, Chatard JC, Carre F, et al.: Prevalence of electrocardiographic abnormalities in West-Asian and African male athletes. Br J Sports Med 2012; 46: 341–7. CrossRef MEDLINE PubMed Central|
|e30.||Rawlins J, Carre F, Kervio G, et al.: Ethnic differences in physiological cardiac adaptation to intense physical exercise in highly trained female athletes. Circulation 2010; 121: 1078–85. CrossRef MEDLINE|
|e31.||Biffi A, Pelliccia A, Verdile L, et al.: Long-term clinical significance of frequent and complex ventricular tachyarrhythmias in trained athletes. J Am Coll Cardiol 2002; 40: 446–52. CrossRef MEDLINE|
|e32.||Pelliccia A, Maron BJ, Di Paolo FM, et al.: Prevalence and clinical significance of left atrial remodeling in competitive athletes. J Am Coll Cardiol 2005; 46: 690–6. CrossRef MEDLINE|
|e33.||Mozaffarian D, Furberg CD, Psaty BM, Siscovick D: Physical activity and incidence of atrial fibrillation in older adults: the cardiovascular health study. Circulation 2008; 118: 800–7. CrossRef MEDLINE PubMed Central|
|e34.||Dickhuth H, Roecker K, Niess A, Hipp A, Heitkamp H: The echocardiographic determination of volume and muscle mass of the heart. Int J Sports Med 1996; 17: 132–9. CrossRef MEDLINE|
|e35.||Urhausen A, Kindermann W: Ein- und zweidimensionale echokardiographische Herzvolumenbestimmung bei Herzgesunden im Vergleich zur röntgenologischen Methode und zu spiroergometrischen Parametern. Herz/Kreisl 1987; 19: 525–8.|
|e36.||Kindermann W: Das Sportherz. Dtsch Z Sportmed 2000; 51: 307–8.|
|e37.||Scharhag J: Akute und chronische Effekte von Ausdauerbelastungen auf das Herz bei Sportlern, gesunden Normalpersonen und Patienten. Habilitationsschrift, Universität des Saarlandes 2009.|
|e38.||George K: Left ventricular diastolic function in athletes. Dtsch Z Sportmed 2012; 63: 63–8.|
|e39.||D’Andrea A, Riegler L, Golia E, et al.: Range of right heart measurements in top-level athletes: The training impact. Int J Cardiol 2011; E-Pub ahead of print. MEDLINE|
|e40.||D’Andrea A, Caso P, Bossone E, et al.: Right ventricular myocardial involvement in either physiological or pathological left ventricular hypertrophy: an ultrasound speckle-tracking two-dimensional strain analysis. Eur J Echocardiogr 2010; 11: 492–500. CrossRef MEDLINE|
|e41.||D’Ascenzi F, Cameli M, Zaca V, et al.: Supernormal diastolic function and role of left atrial myocardial deformation analysis by 2D speckle tracking echocardiography in elite soccer players. Echocardiography 2011; 28: 320–6. CrossRef MEDLINE|
|e42.||D’Ascenzi F, Cameli M, Padeletti M, et al.: Characterization of right atrial function and dimension in top-level athletes: a speckle tracking study. Int J Cardiovasc Imaging 2012; Epud ahead of print. MEDLINE|
|e43.||D’Ascenzi F, Cameli M, Lisi M, et al.: Left Atrial Remodelling in Competitive Adolescent Soccer Players. Int J Sports Med 2012; Epub ahead of print. MEDLINE|
|e44.||De Luca A, Stefani L, Pedrizzetti G, Pedri S, Galanti G: The effect of exercise training on left ventricular function in young elite athletes. Cardiovasc Ultrasound 2011; 9: 27. CrossRef MEDLINE PubMed Central|
|e45.||Florescu M, Stoicescu C, Magda S, et al.: “Supranormal” Cardiac Function in Athletes Related to Better Arterial and Endothelial Function. Echocardiography 2010; 27: 659–67. CrossRef MEDLINE|
|e46.||Krieg A, Scharhag J, Kindermann W, Urhausen A: Cardiac tissue Doppler imaging in sports medicine. Sports Med 2007; 37: 15–30. CrossRef MEDLINE|
|e47.||Krol W, Braksator W, Kasprzak JD, et al.: The influence of extreme mixed exertion load on the right ventricular dimensions and Function in Elite Athletes: A Tissue Doppler Study. Echocardiography 2011; 28: 753–60. CrossRef MEDLINE|
|e48.||Knebel F, Schimke I, Schroeckh S, et al.: Myocardial Function in Older Male Amateur Marathon Runners: Assessment by Tissue Doppler Echocardiography, Speckle Tracking, and Cardiac Biomarkers. J Am Soc Echocardiogr 2009; 22: 803–9. CrossRef MEDLINE|
|e49.||Scharhag J, Mayer F: Kardiale Funktion im Saisonverlauf bei hochtrainierten Ausdauerathleten. BISp-Jahrbuch Forschungsförderung 2010/11, Bundesinstitut für Sportwissenschaft, Bonn 2011: 41–4.|
|e50.||George K, Spence A, Naylor LH, Whyte GP, Green DJ: Cardiac adaptation to acute and chronic participation in endurance sports. Heart 2011; 97: 1999–2004. CrossRef MEDLINE|
|e51.||Shave R, Oxborough D: Exercise-Induced Cardiac Injury: Evidence From Novel Imaging Techniques and Highly Sensitive Cardiac Troponin Assays. Prog Cardiovasc Dis 2012; 54: 407–15. CrossRef MEDLINE|
|e52.||Scharhag J, Knebel F, Mayer F, Kindermann W: Schadet Marathonlaufen dem Herz? Ein Update. Dtsch Z Sportmed 2011; 62: 293–8.|
|e53.||Shave R, George K, Whyte G, Hart E, Middleton N: Postexercise changes in left ventricular function: the evidence so far. Med Sci Sports Exerc 2008; 40: 1393–9. CrossRef MEDLINE|
|e54.||Heidbuchel H, La Gerche A: The right heart in athletes. Evidence for exercise-induced arrhythmogenic right ventricular cardiomyopathy. Herzschrittmacherther Elektrophysiol 2012; 23: 82–6. MEDLINE|
|e55.||Kindermann W, Corrado D, Scharhag J: The right heart in athletes. Do we really have sufficient evidence for exercise-induced arrhythmogenic right ventricular cardiomyopathy? Herzschrittmacherther Elektrophysiol 2012; 23: 144–5; author reply 145–6. MEDLINE|
|e56.||Scharhag J, Schneider G, Kürschner R, Urhausen A, Mayer F, Kindermann W: Right and left ventricular mass and function in strength athletes determined by MRI. Med Sci Sports Exerc 2009; 41(Suppl 5): 118. CrossRef|
|e57.||Spence AL, Naylor LH, Carter HH, et al.: A prospective randomised longitudinal MRI study of left ventricular adaptation to endurance and resistance exercise training in humans. J Physiol 2011; 589: 5443–52. MEDLINE PubMed Central|
|e58.||Fagard R: Athlete’s heart. Heart 2003; 89: 1455–61. CrossRef MEDLINE PubMed Central|
|e59.||Prior DL, La Gerche A: The athlete’s heart. Heart 2012; 98: 947–55. CrossRef MEDLINE|
|e60.||Shave R, George K, Atkinson G, et al.: Exercise-Induced Cardiac Troponin T release: A Meta-Analysis. Med Sci Sports Exerc 2007; 39: 2099–2106. CrossRef MEDLINE|
|e61.||Mingels A, Jacobs L, Michielsen E, Swaanenburg J, Wodzig W, van Dieijen-Visser M: Reference population and marathon runner sera assessed by highly sensitive cardiac troponin T and commercial cardiac troponin T and I assays. Clin Chem 2009; 55: 101–8. CrossRef MEDLINE|
|e62.||Saravia SG, Knebel F, Schroeckh S, et al.: Cardiac troponin T release and inflammation demonstrated in marathon runners. Clin Lab 2010; 56: 51–8. MEDLINE|
|e63.||Scharhag J, Herrmann M, Urhausen A, Haschke M, Herrmann W, Kindermann W: Independent elevations of N-terminal pro-brain natriuretic peptide and cardiac troponins in endurance athletes after prolonged strenuous exercise. Am Heart J 2005; 150: 1128–34. CrossRef MEDLINE|
|e64.||Hickman PE, Potter JM, Aroney C, et al.: Cardiac troponin may be released by ischemia alone, without necrosis. Clin Chim Acta 2010; 411: 318–23. CrossRef MEDLINE|
|e65.||Koller A: Exercise-induced increases in cardiac troponins and prothrombotic markers. Med Sci Sports Exerc 2003; 35: 444–8. CrossRef MEDLINE|
|e66.||Almeida SS, Azevedo A, Castro A, et al.: B-type natriuretic peptide is related to left ventricular mass in hypertensive patients but not in athletes. Cardiology 2002; 98: 113–5. CrossRef MEDLINE|
|e67.||Scharhag J, Urhausen A, Herrmann M, et al.: No difference in N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations between endurance athletes with athlete’s heart and healthy untrained controls. Heart 2004; 90: 1055–6. CrossRef MEDLINE PubMed Central|
|e68.||Pagourelias ED, Giannoglou G, Kouidi E, et al.: Brain natriuretic peptide and the athlete’s heart: a pilot study. Int J Clin Pract 2010; 64: 511–7. CrossRef MEDLINE|
|e69.||Scharhag J, Kindermann W: Verhalten der kardialen Marker BNP und Troponin nach standardisierten Belastungen bei Leistungssportlern mit und ohne Sportherz. BISp-Jahrbuch Forschungsförderung 2006/2007, Bundesinstitut für Sportwissenschaft, Bonn 2007: 73–8.|
|e70.||Ruiz JR, Moran M, Arenas J, Lucia A: Strenuous endurance exercise improves life expectancy: it’s in our genes. Br J Sports Med 2011; 45: 159–61. CrossRef MEDLINE|
|e71.||Grimsmo J, Maehlum S, Moelstad P, Arnesen H: Mortality and cardiovascular morbidity among long-term endurance male cross country skiers followed for 28–30 years. Scand J Med Sci Sports 2011; 21: e351–8. CrossRef MEDLINE|
|e72.||Karvonen MJ, Klemola H, Virkajarvi J, Kekkonen A: Longevity of endurance skiers. Med Sci Sports 1974; 6: 49–51. MEDLINE|
|e73.||Baggish AL, Weiner RB, Kanayama G, et al.: Long-term anabolic-androgenic steroid use is associated with left ventricular dysfunction. Circ Heart Fail 2010; 3: 472–6. CrossRef MEDLINE PubMed Central|
|e74.||Farahmand BY, Ahlbom A, Ekblom O, et al.: Mortality amongst participants in Vasaloppet: a classical long-distance ski race in Sweden. J Intern Med 2003; 253: 276–83. CrossRef MEDLINE|
|e75.||van Saase JL, Noteboom WM, Vandenbroucke JP: Longevity of men capable of prolonged vigorous physical exercise: a 32 year follow up of 2259 participants in the Dutch eleven cities ice skating tour. BMJ 1990; 301: 1409–11. CrossRef MEDLINE PubMed Central|
|e76.||Devereux R, Alonso D, Lutas E, et al.: Echocardiographic assessement of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol 1986; 57: 450–8. CrossRef MEDLINE|
|e77.||Teichholz L, Kreulen T, Herman M, Gorlin R: Problems in echocardiographic volume determinations: echocardiographic-angiographic correlations in the presence or absence of asynergy. Am J Cardiol 1976; 37: 7–11. CrossRef MEDLINE|
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