Correspondence

Numerous Errors

Dtsch Arztebl Int 2013; 110(33-34): 557. DOI: 10.3238/arztebl.2013.0557a

Seifert, R

LNSLNS

In Figure 4 in his review article (1), Schleußner shows a smooth muscle cell in the uterus and signal transduction mechanisms. Unfortunately, there are numerous errors in the accompanying text.

The β-adrenergic receptor in the uterus is the β2-adrenoceptor. This matters because the pharmacological agents used are β2-adrenoceptor agonists ([2], page 433).

There are different G proteins. The G protein involved in the signal transduction of the β2-adrenoceptor is the stimulatory Gs protein ([2], page 320).

The represented oxytocin receptors and prostaglandin receptors also act through G proteins—in particular, Gq proteins. Also, for these receptors, phospholipase C as an effector is missing. There is not only one prostaglandin receptor, but it needs to be specified that prostaglandin F2α induces a contraction of the smooth muscle cells through the FP-receptor ([2], page 445).

The receptors are represented by different symbols. The prostaglandin receptor suggests a channel-like structure with one pore and two receptor units. This is erroneous. Prostaglandin receptors are not among the group of the ligand-controlled ion channels but among the group of G-protein-linked receptors. All depicted receptors should have been represented with 7 transmembrane domains ([2], page 64–66).

There is no molecule with the name “inosidol phosphate.” The molecule that mobilizes Ca2+ from intracellular stores is called inosidol-1,4,5-trisphosphate and originates from the breakdown of phosphatidylinositol-4,5-bisphosphate through phospholipase C ([2], page 64–66).

The soluble guanylyl cyclase as a receptor for NO-pharmacological agents is lacking from the figure. Guanylyl cyclase synthesizes cGMP from GTP. Guanylyl cyclase should have been included in the figure because cAMP-synthesizing adenylyl cyclase is also shown ([2], page 535).

Calcium channel antagonists of the dihydropyridine type, such as nifedipine, inhibit the Ca2+ influx through voltage-dependent calcium channels located in the plasma membrane, not the release of calcium from intracellular stores ([2], page 505).

Indomethacine is obsolete because of its high rate of adverse side effects and should be replaced with substances that are better tolerated , such as ibuprofen ([2], page 211–12).

DOI: 10.3238/arztebl.2013.0557a

Prof. Dr. med. Roland Seifert
Institut für Pharmakologie
Medizinische Hochschule Hannover
seifert.roland@mh-hannover.de

Conflict of interest statement

The author declares that no conflict of interest exists.

1.
Schleußner E: The prevention, diagnosis and treatment of premature labor. Dtsch Arztebl Int 2013; 110(13): 227–36. VOLLTEXT
2.
Mutschler E, Geisslinger G, Kroemer HK, Menzel S, Ruth P (eds.): Mutschler Arzneimittelwirkungen: Pharmakologie, Klinische Pharmakologie, Toxikologie. 10th edition. Stuttgart: Wissenschaftliche Verlagsgesellschaft 2013.
1.Schleußner E: The prevention, diagnosis and treatment of premature labor. Dtsch Arztebl Int 2013; 110(13): 227–36. VOLLTEXT
2.Mutschler E, Geisslinger G, Kroemer HK, Menzel S, Ruth P (eds.): Mutschler Arzneimittelwirkungen: Pharmakologie, Klinische Pharmakologie, Toxikologie. 10th edition. Stuttgart: Wissenschaftliche Verlagsgesellschaft 2013.

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