Polysomnographic Screening Helpful
This commendable review on severe asthma lists gastroesophageal reflux disease (GERD) as one of the potential comorbidities or triggers for the condition (1). In this context, I would like to highlight the important role of sleep-related breathing disorders, in particular of obstructive sleep apnea (OSA). Odds ratios of 3.6 and, for older asthma patients, even 6.67 have been reported for the association between OSA and the exacerbation of bronchial asthma (2, 3).
Should simple questions asked when taking a patient’s history raise the suspicion of OSA, ambulatory polysomnography screening can easily be performed to verify the diagnosis. In case of positive initial findings, further prospective studies will be required to clarify the role of CPAP treatment in improving asthma control (3).
PD Dr. med. Selcuk Tasci
Conflict of interest statement
The authors declare that no conflict of interest exists.
|1.||Lommatzsch M, Virchow JC: Severe asthma: definition, diagnosis and treatment. Dtsch Arztebl Int 2014; 111: 847–55 VOLLTEXT|
|2.||ten Brinke A, Sterk PJ, Masclee AA, et al. :Risk factors of frequent exacerbations in difficult-to-treat asthma. Eur Respir J. 2005, 26:812–8 CrossRef MEDLINE|
|3.||Teodorescu M, Polomis DA, Gangnon RE, et al.: Obstructive sleep apnea and asthma: associations and treatment implications. Sleep Disord 2013; 2013: 251567. doi: 10.1155/2013/251567. Epub 2013 CrossRef|