The Quality of Postoperative Pain Therapy in German Hospitals
The effect of structural and procedural variables
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Background: Many patients in German hospitals complain of inadequate treatment of their postoperative pain. Hospital-related structural and procedural variables may affect pain perception and patient satisfaction. We studied the association of individual variables with outcome quality.
Methods: Data from the years 2011 to 2014 from the world’s largest acute pain registry (QUIPS) were evaluated. The analysis was performed with mixed linear regression models.
Results: We studied registry data from 138 German hospitals concerning four commonly performed types of operations (total number of operations, 21 114) and found that the intensity of pain, functional impairment, and satisfaction with postoperative pain therapy were all highly variable from one hospital to another. Patients in university hospitals complained more often than those in standard care facilities of highly intense pain (odds ratio [OR] 2.44; 95% confidence interval [CI] [1.18; 5.04]) and dissatisfaction (OR 3.58 [1.85; 6.93]). In specialized centers as well, pain intensity (OR 1.39 [1.06; 1.83]) and dissatisfaction (OR 1.59 [1.25; 2.02]) were higher. Pain-related limitation of movement was also reported more commonly in university hospitals (OR 2.12 [0.87; 5.16]) and specialized centers (OR 1.87 [1.33; 2.65]) than in standard care facilities. Less pain-related limitation of movement and higher satisfaction were reported in hospitals in which pain was documented in the patients’ charts and the patients felt adequately informed about the treatment options.
Conclusion: The current state of postoperative pain therapy leaves much room for improvement. Quality indicators in the field of acute pain medicine might help improve patient care.
Inadequate treatment of postoperative pain in hospital is still a common complaint by patients in Germany (1, 2). This is an unacceptable state of affairs. There has been an S3 guideline on postoperative pain therapy in Germany since 2007 (3) (expired 1 April 2014, currently undergoing revision). Despite improvements in some areas, severe deficits remain in the implementation of guideline-compliant recommendations, e.g., for availability of acute pain services, compliance with pain documentation, or use of evidence-based treatment procedures (1, 4–7).
However, evidence-based treatment does not necessarily lead to better treatment outcomes. For example, neither regular pain assessment nor guideline-compliant postoperative treatment is always associated with less pain (8, 9).
Subjective perception of pain is influenced by numerous, often hospital-specific variables: factors such as attention and empathy from hospital staff, as well as regular care by the same staff members (10, 11), provision of information to the patient (12), and the local physical environment (13), may all play a part.
The aim of this study was to investigate the impact of selected structural and procedural variables in German hospitals on the outcome quality of postoperative pain therapy from the viewpoint of the patient. Pain treatment and outcome after four frequently performed operations were evaluated.
We analyzed a sample of recent prospectively acquired registry data from the QUIPS initiative (Qualitätsverbesserung in der postoperativen Schmerztherapie; Quality Improvement in Postoperative Pain Therapy). QUIPS is the world’s largest acute pain registry and contains data on parameters of process quality and outcome quality from the patient’s perspective. The QUIPS project was set up in 2003 with funding from the German Federal Ministry of Health (14, 15) and approved by the ethics committee of the Jena University Hospital.
The hospitals participating in QUIPS acquire data from a sample of their patients on the first day after operation by means of a standardized procedure using a validated questionnaire (16). The outcome parameters recorded include, among others, pain intensity, negative consequences of pain, and adverse effects. Moreover, selected hospital-specific structural parameters and treatment process data are documented. The anonymized data are transmitted to a central registry.
The influence of hospital-specific structural variables was evaluated on the basis of QUIPS registry data for four frequently performed operations in the period 2011 to 2014: “laparoscopic cholecystectomy” (OPS 5–511.11), “laparoscopic herniotomy” or “endoscopic herniotomy” (OPS 5–530.31–32), “hip joint replacement” (OPS 5–820.00, 5–820.01, 5–820.02), and “knee joint replacement”(OPS 5–822.00, 5–822.01, 5.822.02, 5–822.11, 5.822.12). (The Operationen- und Prozedurenschlüssel [OPS] is the German modification of the International Classification of Procedures in Medicine (ICDM).) A high amount of consistent data were acquired in this 4-year period.
The chosen indicators of outcome quality from the patient’s perspective were the patient’s assessments of pain intensity (greatest intensity since operation [11-point numerical rating scale (NRS): 0 = no pain, 10 = worst imaginable pain), postoperative function (restriction of motion and mobilization by pain, yes/no), and satisfaction with postoperative pain therapy (16-point scale: 0 = completely unsatisfied, 15 = absolutely satisfied) (16).
Guided by previous publications (4, 17), we selected the following as hospital structural variables: hospital size (number of beds), ownership (confessional, communal, private, federal state), and level of care (standard, specialized, maximum care other than university hospital, university hospital).
The parameters pain documentation (“Pain documented in medical record?”) and provision of information to the patient (“Were you informed about the various options for treating your pain?”) were chosen as variables of treatment processes.
At patient level, the following characteristics were considered as variables potentially influencing outcome: patient’s age and sex, pre-existing chronic pain, patient’s physical condition (classified according to the American Society of Anesthesiologists [ASA]), and operating time.
The statistical procedures used for analysis were as follows (details can be found in the eBox [eFigures 1–4, eTables 1–8]): The differences in outcome quality among the hospitals were initially depicted descriptively. Generalized mixed linear regression models were used to explore the associations between the structural and process variables and outcome quality. Estimates of model quality can be found in eTable 8. Each potential variable of structure and the treatment process was initially considered alone, with adjustment for the individual hospital, for patient variables (age, sex, pre-existing chronic pain, ASA status), and for operating time (models I).
The structural variables were then adjusted for the two dichotomous variables of the treatment process, pain documentation and patient information (models II).
The analysis proceeded such that odds ratios (OR) >1 signified an outcome quality that was poorer from the patient’s perspective. Two-sided p-values without correction for multiple comparisons were determined as the focus was on effect estimators and 95% confidence intervals (CI). The analyses were carried out using the software packages R 3.2.2 and SAS 9.4.
The QUIPS registry contains data sets for 167 598 patients in the period 2011 to 2014, including 21 114 data sets from 138 hospitals for the selected operations. The ownership of the hospitals was as follows: confessional, n = 13; communal, n = 25; private, n = 83; federal state, n = 7; other/mixed, n = 5; unknown, n = 5. Table 1 shows the distribution of the four operations according to level of care.
Postoperative pain intensity, pain-related functional restriction, and patient satisfaction varied widely among individual hospitals. Patients at the ten “worst” hospitals reported pain intensity of 6.3 ± 2.2, compared with 3.6 ± 2.1 at the ten “best” hospitals (11-point NRS; mean ± standard deviation). This large variation was independent of operation type (Figure 1, eFigures 1–2). The distribution of the mean responses for the three dichotomized variables of outcome quality for all operations is shown in eFigure 3.
The findings of regression analysis of the dichotomized variables can be found in Table 2, expressed as OR with 95% CI. These figures summarize the potential influence of structural and process variables on the results after adjustment for hospital, patient characteristics, and operating time (models I).
Globally, the type of hospital ownership had practically no effect (Table 2). Hospital size (number of beds) also played no essential part. The parameter with the greatest influence on outcome quality was level of care. Patients in university hospitals (OR 2.44 [1.18; 5.04]) and specialized centers (OR 1.39 [1.06; 1.83]) more frequently reported high intensity of pain than those in standard care facilities. They were also more likely to be dissatisfied (university hospitals: OR 3.58 [1.85; 6.93]; specialized centers: 1.59 [1.25; 2.02]). Pain-related functional restriction was reported more often by patients in university hospitals (OR: 2.12 [0.87; 5.16]) and specialized centers (OR: 1.87 [1.33; 2.65]) than by those treated at standard care facilities (Table 2 and eTable 1).
Those treated in hospitals that documented pain in the medical record and where patients reported having been informed of the various options for pain therapy stated lesser pain-related restriction and greater satisfaction (Table 2).
Moreover, there were moderate correlations (ρSpearman = 0.32–0.51) among the three outcome variables (pain intensity, pain-related functional restriction, and satisfaction) (eFigure 4).
When the process variables of pain documentation and perceived patient information were considered as explanatory covariables (models II), the differences among the levels of care were less pronounced (eTable 2).
The results of this study show clearly that the quality of postoperative pain therapy varies considerably in German hospitals. Patients rated the outcome quality of postoperative pain therapy higher in standard care facilities than they did in specialized centers and university facilities. Documentation of pain in the medical record and particularly provision of information perceived by the patients as sufficient were associated with less pain, less frequent occurrence of pain-related functional restriction, and greater patient satisfaction. Since patient variables were always adjusted for, these differences cannot primarily be explained by mean differences among the patient populations.
Although many hospitals achieve high-quality treatment of postoperative pain in terms of pain intensity, pain-related functional restriction, and patient satisfaction, some display considerable deficits in this regard. The proportion of patients who reported severe postoperative pain (NRS ≥ 5) varied from 10% to 88% in individual hospitals. Reporting of pain-related functional restriction ranged between 27% and 95% (eFigure 3).
Considerable variation in the management of postoperative pain has been described in Germany and elsewhere (1, 2, 18). In a nationwide German survey, more maximum-care facilities than standard-care hospitals claimed to have a qualified acute pain service (4).There were no differences, however, in the existence of written treatment plans, degree of organization, or definition of responsibilities. It should be pointed out that the cited study was confined to structural and process quality; outcome quality was not assessed.
One notable finding of our study is the fact that differences in outcome quality could not simply be explained by number of beds (as an indicator of hospital size). Moreover, the association persists even when taking account of factors in which the hospitals probably differ (e.g., patient age, type of surgery, and operating time). Furthermore, it seems unlikely that university hospitals are less well equipped or possess fewer medical or technical resources.
It may be that hospitals offering higher levels of specialization pay less attention to pain therapy processes. This could be indicated by the results of the extended regression models (models II), in which the differences between hospitals with different levels of care were weaker after adjustment for the process parameters pain measurement and patient information.
“Soft” factors such as higher fluctuation of personnel, lower staff education level, greater anonymity, and/or information and communication deficits could have an impact, as could different expectations on the part of the patients regarding the services offered by the various types of hospitals. Empathy, communication, and ascertainment of overall wellbeing (not just pain intensity) are important factors for perceived outcome quality and patients’ satisfaction with pain therapy (10, 19).
Our study showed hardly any association between the type of hospital ownership and outcome quality. A recent publication reported that privately owned hospitals did not implement acute pain services, quality circles, or treatment standards for pain therapy more often than other hospitals (17). Investigations of treatment quality on the basis of the AQUA quality data found no relevant differences between privately owned and other hospitals (20). The association between hospital ownership, workplace atmosphere, and patient care was the subject of a recent controversial appraisal of health policy in Deutsches Ärzteblatt (21).
The relevant guidelines strongly recommend regular measurement of pain as well as provision of information to the patient (3). Our study showed that informing the patient about postoperative pain therapy had a consistent positive association with outcome quality. This illustrates the importance of patient-centered treatment. Preoperative provision of information and involvement of the patient in treatment decisions have proven to be important predictors of patient satisfaction with postoperative pain therapy (22, 23).
In contrast, the association between routine documentation of pain and outcome quality, though consistent, was less pronounced. This confirms the findings of the European PAIN OUT registry (8).
On the one hand, this could be due to the low validity of pain measurement under routine conditions: large differences have repeatedly been demonstrated between standardized subjective ratings by patients and assessments by hospital staff (24).
On the other hand, it is conceivable that in many hospitals documentation of pain intensity is not always followed by the corresponding treatment. Whether this is due to a lack of treatment protocols or insufficient implementation of such protocols in practice cannot be ascertained from the available data.
In agreement with previous investigations, younger age, female sex, and chronic pain were associated with higher pain intensity (25). This observation underlines the importance of individual treatment planning and puts into perspective the concept of primary “procedure-specific” pain therapy with no attention paid to patient-related risk factors.
The hospitals that participated and the patients included are not necessarily representative of German hospitals as a whole. We attempted to reduce the heterogeneity among the various groups of hospitals by focusing on four frequently performed operations. The operations were all distributed similarly over the different levels of care; this does not entirely exclude distortion by the different spectrum of operations, but makes it less likely.
The selection of the variables of outcome quality is open to criticism, first because they interact with one another, second because further variables (e.g., treatment effects, costs, or long-term consequences) could have been taken into account. The parameter “maximal” pain intensity was selected because it is probably the most commonly reported item in publications on acute pain therapy and reacts more sensitively than resting pain to changes in clinical procedure (1). Functional restriction by pain is viewed as clinically highly relevant in the postoperative phase (26). The importance of patient satisfaction can be debated. It is influenced not so much by pain intensity as by—alongside a number of factors unrelated to treatment—aspects of the perceived quality of treatment and interaction between treater and patient (22). Without wishing to overrate the importance of satisfaction, we believe it to be an adequate supplementary parameter that integrates various dimensions of treatment quality.
In choosing the structural variables, we followed previous publications (4, 17). It should be borne in mind that the parameter “number of beds” is not necessarily correlated with case numbers for specific operations, but rather with the numbers of employees and structural units (departments). Furthermore, the hierarchical data structure (factors at patient and hospital level) was taken into account and adjustment made for the covariables present at patient level. Nevertheless, the possibility cannot be excluded that the observed differences were determined to some extent by yet other variables that were neither measured nor allowed for. Thus, the observation of lower patient satisfaction in university hospitals and specialized centers may be the result of bias (e.g., residual confounding). Moreover, the findings represent associations and permit no conclusions as to cause.
Conclusion and outlook
The relatively large discrepancies among different hospitals in the outcome parameters pain intensity, functional restriction, and satisfaction with postoperative pain therapy show clearly that much still needs to be done in this field. Although there are realistic prospects for improvement, evidence-based treatment strategies, non-binding guidelines, and orientation on indicators with no adequate relation to outcome are not sufficient. Therefore, we welcome the proposal of the federal state health ministers’ conference that quality indicators should be introduced for (acute) pain treatment in German hospitals (27).
Acknowledgments and funding
We are grateful to the societies and professional organizations of anesthetists (DGAI and BDA) and surgeons (DGCH and BDC) in Germany and the corresponding Austrian societies (ÖGARI and ÖGC) for their support of the QUIPS project. The Center for Sepsis Control and Care (CSCC) was financially supported by the German Federal Ministry of Education and Research (BMBF) (project FKZ 10EO1502). The authors received funds from their own hospitals (WM, US, JE), or were supported by third-party funding from the QUIPS project (MK) or within the framework of the CSCC (AS). No further funds were received from other sources.
Conflict of interest statement
Prof. Meißner has received consultancy payments from AcelRX, BioQ Pharma, Grünenthal, Medicines Company, and Menarini, as well as lecture honoraria from BioQ Pharma, Grünethal, Menarini, and Mundipharma. He has received third-party funding from Pfizer and financial support for clinical studies from Grünenthal.
The remaining authors declare that no conflict of interest exists.
Manuscript submitted on 9 August 2016, revised version accepted on
3 January 2017
Translated from the original German by David Roseveare
Prof. Dr. med. Winfried Meißner
Klinik für Anästhesiologie und Intensivmedizin
Am Klinikum 1,
07747 Jena, Germany
eBox, eFigures, eTables:
Division of Pain Medicine, Department of Anesthesiology, Faculty of Medicine, University of Göttingen: Dr. Erlenwein
Department of Anesthesiology and Pain Therapy, Inselspital, Bern University Hospital, and Department of Clinical Research, University of Bern: Prof. Stamer
Research Group Clinical Epidemiology, Center for Sepsis Control and Care (CSCC), Jena University Hospital: Prof. Scherag
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Deutsches Aerzteblatt Online, 201710.3238/arztebl.2017.0462a
Deutsches Aerzteblatt Online, 201710.3238/arztebl.2017.0462b
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