Correspondence

In Reply

Dtsch Arztebl Int 2019; 116: 505. DOI: 10.3238/arztebl.2019.0505b

Kiefmann, R

LNSLNS

Frailty is one of the most important predictors of perioperative risk. Unfortunately, recognizing frailty in the perioperative context is a challenge. This circumstance is at least partially due to the large number of different definitions and assessment tools—a selection of which we presented in our article (1). We completely agree with Lippi’s proposal of “frailty” as an “age-associated syndrome, characterized by decreased biological reserve and resistance to stressors due to functional decline of several physiological systems, which places the individual at enhanced risk of disability, hospitalization and death” (2). Nonetheless, the difficulty of identifying at-risk persons in everyday clinical practice remains. We therefore very much welcome the FRAILOMIC initiative, and we are hopeful that appropriate assessment tools/markers will be developed to allow preoperative detection of vulnerable patients, in order to improve the postoperative outcome of older patients.

On Behalf of the Authors

Prof. Dr. med. Rainer Kiefmann

University Medical Center Hamburg- Eppendorf (UKE), Germany, r.kiefmann@uke.de

Conflict of interest statement

The authors of both contributions declare that no conflict of interest exists.

1.
Mende A, Riegel AK, Plümer L, Olotu C, Goetz AE, Kiefmann R: The determinants of perioperative outcome in frail older patients. Dtsch Arztebl Int 2019; 116: 73–82 VOLLTEXT
2.
Erusalimsky JD, Grillari J, Grune T, et al.: In search of ‚Omics‘-based Biomarkers to predict risk of frailty and its consequences in older individuals: The FRAILOMIC Initiative. Gerontology 2016; 62: 182–90 CrossRef MEDLINE
1.Mende A, Riegel AK, Plümer L, Olotu C, Goetz AE, Kiefmann R: The determinants of perioperative outcome in frail older patients. Dtsch Arztebl Int 2019; 116: 73–82 VOLLTEXT
2.Erusalimsky JD, Grillari J, Grune T, et al.: In search of ‚Omics‘-based Biomarkers to predict risk of frailty and its consequences in older individuals: The FRAILOMIC Initiative. Gerontology 2016; 62: 182–90 CrossRef MEDLINE

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