DÄ internationalArchive17/2020The effects of intensive versus routine treatment in patients with acute kidney injury

Original article

The effects of intensive versus routine treatment in patients with acute kidney injury

An explorative randomized controlled study

Dtsch Arztebl Int 2020; 117: 289-96. DOI: 10.3238/arztebl.2020.0289

Haase-Fielitz, A; Elitok, S; Schostak, M; Ernst, M; Isermann, B; Albert, C; Robra, B; Kribben, A; Haase, M

For technical reasons, the English full text will be published approximately two weeks after the German print edition has been published.

* Die Autoren teilen sich die Erstautorenschaft.
Abteilung für Kardiologie, Immanuel Klinikum Bernau Herzzentrum Brandenburg: PD Dr. Anja Haase-Fielitz
Medizinische Hochschule Brandenburg (MHB) „Theodor Fontane“: PD Dr. Anja Haase-Fielitz
Institut für Sozialmedizin und Gesundheitsökonomie, Otto-von-Guericke Universität Magdeburg: PD Dr. Anja Haase-Fielitz, Prof. Dr. med. Bernt-Peter Robra
Klinik für Nephrologie und Endokrinologie, Klinikum Ernst von Bergmann Potsdam: Dr. med. Saban Elitok
Klinik für Urologie und Kinderurologie, Otto-von-Guericke Universität Magdeburg: Prof. Dr. med. Martin Schostak
Klinik für Orthopädie und Unfallchirurgie, Ameos Klinikum Schönebeck: Martin Ernst
Institut für Laboratoriumsmedizin, Universitätsklinikum Leipzig: Prof. Dr. med. Berend Isermann
MVZ Diaverum Am Neuen Garten Potsdam, Diaverum Deutschland: Dr. med. Christian Albert, Prof. Dr. med. Michael Haase
Medizinische Fakultät, Otto-von-Guericke Universität Magdeburg: Dr. med. Christian Albert, Prof. Dr. med. Michael Haase
Klinik für Nephrologie, Universitätsklinikum Essen: Prof. Dr. med. Andreas Kribben
1.Khadzhynov D, Schmidt D, Hardt J, et al.: The incidence of acute kidney injury and associated hospital mortality. Dtsch Arztebl Int 2019; 116: 397–404 VOLLTEXT
2.Haase M, Kribben A, Zidek W, et al.: Electronic alerts for acute kidney injury. Dtsch Arztebl Int 2017; 114: 1–8 VOLLTEXT
3.Bienholz A, Kribben A: Acute kidney injury: a clinical syndrome. Internist (Berl) 2016; 57: 983–93 CrossRef MEDLINE
4.Meier P, Bonfils RM, Vogt B, Burnand B, Burnier M: Referral patterns and outcomes in noncritically ill patients with hospital-acquired acute kidney injury. Clin J Am Soc Nephrol 2011; 6: 2215–25 CrossRef MEDLINE PubMed Central
5.Chawla LS, Amdur RL, Amodeo S, Kimmel PL, Palant CE: The severity of acute kidney injury predicts progression to chronic kidney disease. Kidney Int 2011; 79: 1361–9 CrossRefMEDLINE PubMed Central
6.Bucaloiu ID, Kirchner HL, Norfolk ER, Hartle JE 2nd, Perkins RM: Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury. Kidney Int 2012; 81: 477–85 CrossRef MEDLINE
7.See EJ, Jayasinghe K, Glassford N, et al.: Long-term risk of adverse outcomes after acute kidney injury: a systematic review and meta-analysis of cohort studies using consensus definitions of exposure. Kidney Int 2019; 95: 160–72 CrossRef MEDLINE
8.Girndt M, Trocchi P, Scheidt-Nave C, Markau S, Stang A: The prevalence of renal failure. Results from the German Health Interview and Examination Survey for Adults, 2008–2011 (DEGS1). Dtsch Arztebl Int 2016; 113: 85–91 VOLLTEXT
9.Chawla LS, Amdur RL, Shaw AD, Faselis C, Palant CE, Kimmel PL: Association between AKI and long-term renal and cardiovascular outcomes in United States veterans. Clin J Am Soc Nephrol 2014; 9: 448–56 CrossRef MEDLINE PubMed Central
10.Collister D, Pannu N, Ye F, et al.: Health care costs associated with AKI. Clin J Am Soc Nephrol 2017; 12: 1733–43 CrossRef MEDLINE PubMed Central
11.Kerr M, Bedford M, Matthews B, O‘Donoghue D: The economic impact of acute kidney injury in England. Nephrol Dial Transplant 2014; 29: 1362–8 CrossRef MEDLINE
12.KDIGO: Clinical practice guideline for acute kidney injury. Kidney Int Suppl 2012. Doi: 10.1038/kisup.2012. www.kdigo.org/wp-content/uploads/2016/10/KDIGO-2012-AKI-Guideline-English.pdf (last accessed on 26 February 2020).
13.Alscher MD, Erley C, Kuhlmann MK: Acute renal failure of nosocomial origin. Dtsch Arztebl Int 2019; 116: 149–58 CrossRef
14.Yang L, Xing G, Wang L, et al.: Acute kidney injury in China: a cross-sectional survey. Lancet 2015; 386: 1465–71 CrossRef
15.Stewart J, Findlay G, Smith N, Kelly K, Mason M: Adding insult to injury: a review of the care of patients who died in hospital with a primary diagnosis of acute kidney injury (acute renal failure). A report of the National Confidential Enquiry into Patient Outcome and Death (2009). London: National Confidential Enquiry into Patient Outcome and Death 2009. www.ncepod.org.uk/2009report1/Downloads/AKI_report.pdf (last accessed on 26. February 2020).
16.Haase-Fielitz A, Ernst M, Lehmanski F, et al.: Treatment, clinical course, and cross-sectoral information transmission in patients with acute-on-chronic kidney injury. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2019; 62: 773–81 CrossRef MEDLINE
17.Schindler R, Hutagalung R, Jörres A, et al.: Treatment of acute renal failure in Germany: a structural analysis. Dtsch Med Wochenschr 2014; 139: 1701–6 CrossRef MEDLINE
18.Balasubramanian G, Al-Aly Z, Moiz A, et al.: Early nephrologist involvement in hospital-acquired acute kidney injury: a pilot study. Am J Kidney Dis 2011; 57: 228–34 CrossRef MEDLINE
19.Wilson FP, Shashaty M, Testani J, et al.: Automated, electronic alerts for acute kidney injury: a single-blind, parallel-group, randomised controlled trial. Lancet 2015; 385: 1966–74 CrossRef
20.Park S, Baek SH, Ahn S, et al.: Impact of electronic acute kidney injury (AKI) alerts with automated nephrologist consultation on detection and severity of AKI: a quality improvement study. Am J Kidney Dis 2018; 71: 9–19 CrossRef MEDLINE
21.Selby NM, Casula A, Lamming L, et al.: An organizational-level program of intervention for AKI: a pragmatic stepped wedge cluster randomized trial. J Am Soc Nephrol 2019; 30: 505–15 CrossRef MEDLINE PubMed Central
22.Wu Y, Chen Y, Li S, et al.: Value of electronic alerts for acute kidney injury in high-risk wards: a pilot randomized controlled trial. Int Urol Nephrol 2018; 50: 1483–8 CrossRef MEDLINE PubMed Central
23.Kolhe NV, Staples D, Reilly T, et al.: Impact of compliance with a care bundle on acute kidney injury outcomes: a prospective observational study. PLoS One 2015; 10: e0132279 CrossRef MEDLINE PubMed Central
24.Chandrasekar T, Sharma A, Tennent L, Wong C, Chamberlain P, Abraham KA: A whole system approach to improving mortality associated with acute kidney injury. QJM. 2017; 110: 657–66 CrossRef MEDLINE
25.de Zeeuw D, Akizawa T, Audhya P, et al.: Bardoxolone methyl in type 2 diabetes and stage 4 chronic kidney disease. N Engl J Med 2013; 369: 2492–503 CrossRef MEDLINE PubMed Central
26.Perkovic V, Jardine MJ, Neal B, et al.: Canagliflozin and renal outcomes in type 2 diabetes and nephropathy. N Engl J Med 2019; 380: 2295–306 CrossRef MEDLINE
27.Jo YY, Kim JY, Lee JY, Choi CH, Chang YJ, Kwak HJ: The effect of intraoperative dexmedetomidine on acute kidney injury after pediatric congenital heart surgery: A prospective randomized trial. Medicine (Baltimore) 2017; 96: e7480 CrossRef MEDLINE PubMed Central
28.Tomašev N, Glorot X, Rae JW, et al.: A clinically applicable approach to continuous prediction of future acute kidney injury. Nature 2019; 572: 116–9 CrossRef MEDLINE PubMed Central