szmtag Current treatment for benign prostatic hyperplasia (04.12.2020)
DÄ internationalArchive49/2020Current treatment for benign prostatic hyperplasia

cme

Current treatment for benign prostatic hyperplasia

Dtsch Arztebl Int 2020; 117: 843-54. DOI: 10.3238/arztebl.2020.0843

Miernik, A; Gratzke, C

For technical reasons, the English full text will be published approximately two weeks after the German print edition has been published.

Universitätsklinikum Freiburg, Medizinische Fakultät, Klinik für Urologie, Freiburg: Prof. Dr. Dr. med. univ. Arkadiusz Miernik, FEBU, MHBA, Prof. Dr. med. Christian Gratzke
1.Gravas S, Cornu J, Gacci M, et al.: EAU Guidelines on mnagement of non-neurogenic male lower urinary tract symptoms (LUTS), incl. benign prostatic obstruction (BPO). 2019. European Association of Urology 2019. https://uroweb.org/guideline/treatment-of-non-neurogenic-male-luts/ (last accesssed on 19 September 2019).
2.Barry MJ, Fowler FJ Jr, O‘Leary MP, et al.: The American Urological Association symptom index for benign prostatic hyperplasia. The Measurement Committee of the American Urological Association. J Urol 1992; 148: 1549–64 CrossRef
3.Egan KB: The epidemiology of benign prostatic hyperplasia associated with lower urinary tract symptoms: prevalence and incident rates. Urol Clin North Am 2016; 43: 289–97 CrossRef MEDLINE
4.Berry SJ, Coffey DS, Walsh PC, Ewing LL: The development of human benign prostatic hyperplasia with age. J Urol 1984; 132: 474–9 CrossRef
5.Vuichoud C, Loughlin KR: Benign prostatic hyperplasia: epidemiology, economics and evaluation. Can J Urol 2015; 22: 1–6.
6.Gacci M, Corona G, Vignozzi L, et al.: Metabolic syndrome and benign prostatic enlargement: a systematic review and meta-analysis. BJU Int 2015; 115: 24–31 CrossRef MEDLINE
7.Martin SA, Haren MT, Marshall VR, Lange K, Wittert GA; Members of the Florey Adelaide Male Ageing Study: Prevalence and factors associated with uncomplicated storage and voiding lower urinary tract symptoms in community-dwelling Australian men. World J Urol 2011; 29: 179–84 CrossRef MEDLINE
8.Gravas S, Melekos MD: Male lower urinary tract symptoms: how do symptoms: guide our choice of treatment?. Curr Opin Urol 2009; 19: 49–54 CrossRef MEDLINE
9.The National Institute for Health and Care Excellence (NICE), ed.: Lower urinary tract symptoms in men: management. London 2015.
10.Donovan JL, Peters TJ, Abrams P, Brookes ST, de aa Rosette JJ, Schäfer W: Scoring the short form ICSmaleSF questionnaire. International Continence Society. J Urol 2000; 164: 1948–55 CrossRef CrossRef MEDLINE
11.Bryan NP, Chapple CR: Frequency volume charts in the assessment and evaluation of treatment: how should we use them? Eur Urol 2004; 46: 636–40 CrossRef MEDLINE
12.Berges R, Oelke M: Age-stratified normal values for prostate volume, PSA, maximum urinary flow rate, IPSS, and other LUTS/BPH indicators in the German male community-dwelling population aged 50 years or older. World J Urol 2011; 29: 171–8 CrossRef MEDLINE
13.Roehrborn CG: Accurate determination of prostate size via digital rectal examination and transrectal ultrasound. Urology 1998; 51: 19–22 CrossRef
14.Roehrborn CG, Girman CJ, Rhodes T, et al.: Correlation between prostate size estimated by digital rectal examination and measured by transrectal ultrasound. Urology 1997; 49: 548–57 CrossRef
15.Oelke M, Hofner K, Jonas U, de la Rosette JJ, Ubbink DT, Wijkstra H: Diagnostic accuracy of noninvasive tests to evaluate bladder outlet obstruction in men: detrusor wall thickness, uroflowmetry, postvoid residual urine, and prostate volume. Eur Urol 2007; 52: 827–34 CrossRef MEDLINE
16.McConnell JD, Roehrborn CG, Bautista OM, et al.: The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia. New Engl J Med 2003; 349: 2387–98 CrossRef MEDLINE
17.Roehrborn CG: Alfuzosin 10 mg once daily prevents overall clinical progression of benign prostatic hyperplasia but not acute urinary retention: results of a 2-year placebo-controlled study. BJU international 2006; 97: 734–4 CrossRef MEDLINE
18.Cox CE, Hinman F Jr: Experiments with induced bacteriuria, vesical emptying and bacterial growth on the mechanism of bladder defense to infection. J Urol 1961; 86: 739–48 CrossRef
19.Dray EV, Clemens JQ: Recurrent urinary tract infections in patients with incomplete bladder emptying: is there a role for intravesical therapy? Transl Androl Urol 2017; 6: 163–70 CrossRef MEDLINE PubMed Central
20.Bohnen AM, Groeneveld FP, Bosch JL: Serum prostate-specific antigen as a predictor of prostate volume in the community: the Krimpen study. European Urology 2007; 51: 1645–52; discussion 52–3 CrossRef MEDLINE
21.Roehrborn CG, McConnell J, Bonilla J, et al.: Serum prostate specific antigen is a strong predictor of future prostate growth in men with benign prostatic hyperplasia. J Urol 2000; 163: 13–20 CrossRef CrossRef
22.Sriprasad S, Thompson PM: Are men with lower urinary tract symptoms at increased risk of prostate cancer? A systematic review and critique of the available evidence. BJU Int 2001; 87: 127–8 CrossRef MEDLINE
23.Brown CT, O‘Flynn E, Van Der Meulen J, Newman S, Mundy AR, Emberton M: The fear of prostate cancer in men with lower urinary tract symptoms: should symptomatic men be screened? BJU Int 2003; 91: 30–2 CrossRef MEDLINE
24.Anikwe RM: Correlations between clinical findings and urinary flow rate in benign prostatic hypertrophy. Int Surg 1976; 61: 392–4.
25.Clement KD, Burden H, Warren K, Lapitan MC, Omar MI, Drake MJ: Invasive urodynamic studies for the management of lower urinary tract symptoms (LUTS) in men with voiding dysfunction. Cochrane Database Syst Rev 2015 CD011179 CrossRef MEDLINE
26.Lewis AL, Young GJ, Abrams P, et al.: Clinical and patient-reported outcome measures in men referred for consideration of surgery to treat lower urinary tract symptoms: baseline results and diagnostic findings of the urodynamics for prostate surgery trial; randomised evaluation of assessment methods (UPSTREAM). Eur Urol Focus 2019; 5: 340–50 CrossRef MEDLINE
27.Isaacs JT: Importance of the natural history of benign prostatic hyperplasia in the evaluation of pharmacologic intervention. Prostate Suppl 1990; 3: 1–7 CrossRef MEDLINE
28.Kirby RS: The natural history of benign prostatic hyperplasia: what have we learned in the last decade? Urology 2000; 56: 3–6 CrossRef
29.Netto NR Jr, de Lima ML, Netto MR, D‘Ancona CA: Evaluation of patients with bladder outlet obstruction and mild international prostate symptom score followed up by watchful waiting. Urology 1999; 53: 314–6 CrossRef
30.Yap TL, Brown C, Cromwell DA, van der Meulen J, Emberton M: The impact of self-management of lower urinary tract symptoms on frequency-volume chart measures. BJU Int 2009; 104: 1104–8 CrossRef MEDLINE
31.Sebastianelli A, Russo GI, Kaplan SA, et al.: Systematic review and meta-analysis on the efficacy and tolerability of mirabegron for the treatment of storage lower urinary tract symptoms/overactive bladder: comparison with placebo and tolterodine. Int J Urol 2018; 25: 196–205 CrossRef MEDLINE
32.Michel MC, Vrydag W: Alpha1-, alpha2– and beta-adrenoceptors in the urinary bladder, urethra and prostate. Br J Pharmacol 2006; 147: 88–119 CrossRef MEDLINE PubMed Central
33.Djavan B, Chapple C, Milani S, Marberger M: State of the art on the efficacy and tolerability of alpha1-adrenoceptor antagonists in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia. Urology 2004; 64: 1081–8 CrossRef MEDLINE
34.Brousil P, Shabbir M, Zacharakis E, Sahai A: PDE-5 inhibitors for BPH-associated LUTS. Current drug targets 2015; 16: 1180–6 CrossRef MEDLINE
35.Naslund MJ, Miner M: A review of the clinical efficacy and safety of 5alpha-reductase inhibitors for the enlarged prostate. Clin Ther 2007; 29: 17–25 CrossRef MEDLINE
36.Han J, Jung JH, Bakker CJ, Ebell MH, Dahm P: Desmopressin for treating nocturia in men. Cochrane Database Syst Rev 2017; 10: CD012059 CrossRef PubMed Central
37.Allkanjari O, Vitalone A: What do we know about phytotherapy of benign prostatic hyperplasia? Life Sci 2015; 126: 42–56 CrossRef MEDLINE
38.Keehn A, Taylor J, Lowe FC: Phytotherapy for benign prostatic hyperplasia. Curr Urol Rep 2016; 17: 53 CrossRef MEDLINE
39.Pagano E, Laudato M, Griffo M, Capasso R: Phytotherapy of benign prostatic hyperplasia. A minireview. Phytother Res 2014; 28: 949–55 CrossRef MEDLINE
40.Tacklind J, Macdonald R, Rutks I, Stanke JU, Wilt TJ: Serenoa repens for benign prostatic hyperplasia. Cochrane Database Syst Rev 2012; 12: CD001423 CrossRef PubMed Central
e1.Kaplan SA, Lee JY, Meehan AG, Kusek JW: Time course of incident adverse experiences associated with doxazosin, finasteride and combination therapy in men with benign prostatic hyperplasia: the MTOPS trial. J Urol 2016; 195: 1825–9 CrossRef MEDLINE
e2.Roehrborn CG, Siami P, Barkin J, et al.: The effects of combination therapy with dutasteride and tamsulosin on clinical outcomes in men with symptomatic benign prostatic hyperplasia: 4-year results from the CombAT study. Eur Urol 2010; 57: 123–31 CrossRef MEDLINE
e3.Pattanaik S, Mavuduru RS, Panda A, et al.: Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia. Cochrane Database Syst Rev 2018; 11: CD010060 CrossRef MEDLINE PubMed Central
e4.Allison SJ, Gibson W: Mirabegron, alone and in combination, in the treatment of overactive bladder: real-world evidence and experience. Ther Adv Urol 2018; 10: 411–9 CrossRef MEDLINE PubMed Central
e5.Kaplan SA, Roehrborn CG, Rovner ES, Carlsson M, Bavendam T, Guan Z: Tolterodine and tamsulosin for treatment of men with lower urinary tract symptoms and overactive bladder: a randomized controlled trial. JAMA 2006; 296: 2319–28 CrossRef MEDLINE
e6.van Kerrebroeck, Chapple C, Drogendijk T, et al.: Combination therapy with solifenacin and tamulosin oral contolled absorption system in a single tablet for lower urinary tract symptoms in men: efficacy and safety results from the randomised controlled NEPTUNE trial. Eur Urol 2013; 64: 1003–12 CrossRef MEDLINE
e7.Cindolo L, Pirozzi L, Fanizza C, et al.: Drug adherence and clinical outcomes for patients under pharmacological therapy for lower urinary tract symptoms related to benign prostatic hyperplasia: population-based cohort study. Eur Urol 2015; 68: 418–25 CrossRef MEDLINE
e8.Gratzke C, Schlenker B, Seitz M, et al.: Complications and early postoperative outcome after open prostatectomy in patients with benign prostatic enlargement: results of a prospective multicenter study. J Urol 2007; 177: 1419–22 CrossRef MEDLINE
e9.Reich O, Gratzke C, Bachmann A, et al.: Morbidity, mortality and early outcome of transurethral resection of the prostate: a prospective multicenter evaluation of 10,654 patients. J Urol 2008; 180: 246–9 CrossRef MEDLINE
e10.Zhang Y, Yuan P, Ma D, et al.: Efficacy and safety of enucleation vs. resection of prostate for treatment of benign prostatic hyperplasia: a meta-analysis of randomized controlled trials. Prostate Cancer Prostatic Dis 2019; 22: 493–508 CrossRef MEDLINE
e11.El-Hakim A, Elhilali MM: Holmium laser enucleation of the prostate can be taught: the first learning experience. BJU Int 2002; 90: 863–9 CrossRef MEDLINE
e12.Kampantais S, Dimopoulos P, Tasleem A, Acher P, Gordon K, Young A: Assessing the learning curve of holmium laser enucleation of prostate (HoLEP). A systematic review. Urology 2018; 120: 9–22 CrossRef MEDLINE
e13.Lai S, Peng P, Diao T, et al.: Comparison of photoselective green light laser vaporisation versus traditional transurethral resection for benign prostate hyperplasia: an updated systematic review and meta-analysis of randomised controlled trials and prospective studies. BMJ open 2019; 9: e028855 CrossRef MEDLINE PubMed Central
e14.Sievert KD, Schonthaler M, Berges R, et al.: Minimally invasive prostatic urethral lift (PUL) efficacious in TURP candidates: a multicenter German evaluation after 2 years. World J Urol 2019; 37: 1353–60 CrossRef MEDLINE PubMed Central
e15.McVary KT, Rogers T, Roehrborn CG: Rezum water vapor thermal therapy for lower urinary tract symptoms associated with benign prostatic hyperplasia: 4-year results from randomized controlled study. Urology 2019; 126: 171–9 CrossRef MEDLINE
e16.Desai M, Bidair M, Zorn KC, et al.: Aquablation for benign prostatic hyperplasia in large prostates (80–150 mL): 6-month results from the WATER II trial. BJU Int 2019; 124: 321–8 CrossRef MEDLINE
e17.Gilling P, Barber N, Bidair M, et al.: Two-year outcomes after aquablation compared to TURP: Efficacy and ejaculatory improvements sustained. Adv Ther 2019; 36: 1326–36 CrossRef MEDLINE PubMed Central
e18.Suarez-Ibarrola R, Bach T, Hein S, et al.: Efficacy and safety of aquablation of the prostate for patients with symptomatic benign prostatic enlargement: a systematic review. World J Urol 2020; 38: 1147–63 CrossRef MEDLINE
e19.Abt D, Hechelhammer L, Mullhaupt G, et al.: Comparison of prostatic artery embolisation (PAE) versus transurethral resection of the prostate (TURP) for benign prostatic hyperplasia: randomised, open label, non-inferiority trial. BMJ 2018; 361: k2338 CrossRef MEDLINE PubMed Central
e20.Zumstein V, Betschart P, Vetterlein MW, et al.: Prostatic artery embolization versus standard surgical treatment for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a systematic review and meta-analysis. Eur Urol Focus 2019; 5: 1091–100 CrossRef MEDLINE
e21.Porpiglia F, Fiori C, Bertolo R, et al.: 3-year follow-up of temporary implantable nitinol device implantation for the treatment of benign prostatic obstruction. BJU Int 2018; 122: 106–12 CrossRef MEDLINE
e22.Yuan J-Q, Mao C, Wong SY-S, et al.: Comparative effectiveness and safety of monodrug therapies for lower urinary tract symptoms associated with benign prostatic hyperplasia: a network meta-analysis. Medicine 2015; 94: e974 CrossRef MEDLINE PubMed Central
e23.Nickel JC, Sander S, Moon TD: A meta-analysis of the vascular-related safety profile and efficacy of alpha-adrenergic blockers for symptoms related to benign prostatic hyperplasia. Int J Clin Pract 2008; 62: 1547–59 CrossRef MEDLINE PubMed Central
e24.Chatziralli IP, Sergentanis TN: Risk factors for intraoperative floppy iris syndrome: a meta-analysis. Ophthalmology 2011; 118: 730–5 CrossRef MEDLINE
e25.Gacci M, Ficarra V, Sebastianelli A, et al.: Impact of medical treatments for male lower urinary tract symptoms due to benign prostatic hyperplasia on ejaculatory function: a systematic review and meta-analysis. J Sex Med 2014; 11: 1554–66 CrossRef MEDLINE
e26.Kim JH, Baek MJ, Sun HY, et al.: Efficacy and safety of 5 alpha-reductase inhibitor monotherapy in patients with benign prostatic hyperplasia: a meta-analysis. PloS one 2018; 13: e0203479 CrossRef MEDLINE PubMed Central
e27.Kuntz RM, Lehrich K, Ahyai SA: Holmium laser enucleation of the prostate versus open prostatectomy for prostates greater than 100 grams: 5-year follow-up results of a randomised clinical trial. Eur Urol 2008; 53: 160–6 CrossRef MEDLINE
e28. Gacci M, Corona G, Salvi M, et al.: A systematic review and meta-analysis on the use of phosphodiesterase 5 inhibitors alone or in combination with α-blockers for lower urinary tract symptoms due to benign prostatic hyperplasia. Eur Urol 2012; 61: 994–1003 CrossRef MEDLINE
e29. Yokoyama T, Uematsu K, Watanabe T, et al.: Naftopidil and propiverine hydrochloride for treatment of male lower urinary tract symptoms suggestive of benign prostatic hyperplasia and concomitant overactive bladder: a prospective randomized controlled study. Scand J Urol Nephrol 2009; 43: 307–14 CrossRef MEDLINE
e30.Höfner K, Burkart M, Jacob G, Jonas U: Safety and efficacy of tolterodine extended release in men with overactive bladder symptoms and presumed non-obstructive benign prostatic hyperplasia. World J Urol 2007; 25: 627–33 CrossRef MEDLINE
e31. Kaplan SA, Goldfischer ER, Steers WD, Gittelman M, Andoh M, Forero-Schwanhaeuser S: Solifenacin treatment in men with overactive bladder: effects on symptoms and patient-reported outcomes. Aging Male 2010; 13: 100–7 CrossRef MEDLINE
e32.Herschorn S, Jones JS, Oelke M, MacDiarmid S, Wang JT, Guan Z: Efficacy and tolerability of fesoterodine in men with overactive bladder: a pooled analysis of 2 phase III studies. Urology 2010; 75: 1149–55 CrossRef MEDLINE
e33.Abrams P, Kaplan S, De Koning Gans HJ, Millard R: Safety and tolerability of tolterodine for the treatment of overactive bladder in men with bladder outlet obstruction. J Urol 2006; 175: 999–1004; discussio CrossRef
e34.Chapple CR, Kaplan SA, Mitcheson D, et al.: Randomized double-blind, active-controlled phase 3 study to assess 12-month safety and efficacy of mirabegron, a beta(3)-adrenoceptor agonist, in overactive bladder. Eur Urol 2013; 63: 296–305 CrossRef MEDLINE
e35. Khullar V, Amarenco G, Angulo JC, et al.: Efficacy and tolerability of mirabegron, a β3-adrenoceptor agonist, in patients with overactive bladder: results from a randomised European–Australian phase 3 trial. Eur Urol 2013; 63: 283–95 CrossRef MEDLINE
e36. Nitti VW, Auerbach S, Martin N, Calhoun A, Lee M, Herschorn S: Results of a randomized phase III trial of mirabegron in patients with overactive bladder. J Urol 2013; 189: 1388–95 CrossRef MEDLINE
e37. Wagg A, Staskin D, Engel E, Herschorn S, Kristy RM, Schermer CR: Efficacy, safety, and tolerability of mirabegron in patients aged ≥ 65 yr with overactive bladder wet: a phase IV, double-blind, randomised, placebo-controlled study (PILLAR). Eur Urol 2020; 77: 211–20 CrossRef MEDLINE
e38.Liu Y, Cheng Y, Zhuo L, et al.: Impact on sexual function of endoscopic enucleation vs transurethral resection of the prostate for lower urinary tract symptoms due to benign prostatic hyperplasia: A systematic review and meta-analysis. J Endourol 2020; 34:1064–74 CrossRef MEDLINE
e39.Sakalis VI, Karavitakis M, Bedretdinova D, et al.: Medical treatment of nocturia in men with lower urinary tract symptoms: systematic review by the European Association of Urology Guidelines Panel for male lower urinary tract symptoms. Eur Urol 2017; 72: 757–69 CrossRef MEDLINE
e40.Kim HJ, Sun HY, Choi H, et al.: Efficacy and safety of initial combination treatment of an alpha blocker with an anticholinergic medication in benign prostatic hyperplasia patients with lower urinary tract symptoms: updated meta-analysis. PLoS One 2017; 12: e0169248 CrossRef MEDLINE PubMed Central
e41. Drake MJ, Oelke M, Snijder R, et al.: Incidence of urinary retention during treatment with single tablet combinations of solifenacin+ tamsulosin OCAS™ for up to 1 year in adult men with both storage and voiding LUTS: a subanalysis of the NEPTUNE/NEPTUNE II randomized controlled studies. PloS one 2017; 12 CrossRef MEDLINE PubMed Central
e42.Lourenco T, Shaw M, Fraser C, MacLennan G, N’Dow J, Pickard R: The clinical effectiveness of transurethral incision of the prostate: a systematic review of randomised controlled trials. World J Urol 2010; 28: 23–32 CrossRef MEDLINE
e43. Cornu J-N, Ahyai S, Bachmann A, et al.: A systematic review and meta-analysis of functional outcomes and complications following transurethral procedures for lower urinary tract symptoms resulting from benign prostatic obstruction: an update. Eur Urol 2015; 67: 1066–96 CrossRef MEDLINE
e44. Ahyai SA, Gilling P, Kaplan SA, et al.: Meta-analysis of functional outcomes and complications following transurethral procedures for lower urinary tract symptoms resulting from benign prostatic enlargement. Eur Url 2010; 58: 384–97 CrossRef MEDLINE
e45. Alexander CE, Scullion MMF, Omar MI, et al.: Bipolar versus monopolar transurethral resection of the prostate for lower urinary tract symptoms secondary to benign prostatic obstruction. Cochrane Database Syst Rev 2019; CD009629 CrossRef MEDLINE
e46.Wroclawski ML, Carneiro A, Amarante RDM, et al.: ‘Button type’bipolar plasma vaporisation of the prostate compared with standard transurethral resection: a systematic review and meta-analysis of short-term outcome studies. BJU international 2016; 117: 662–8 CrossRef MEDLINE
e47. Razzaghi MR, Mazloomfard MM, Mokhtarpour H, Moeini A: Diode laser (980 nm) vaporization in comparison with transurethral resection of the prostate for benign prostatic hyperplasia: randomized clinical trial with 2-year follow-up. Urology 2014; 84: 526–32 CrossRef MEDLINE
e48.Deng Z, Sun M, Zhu Y, et al.: Thulium laser VapoResection of the prostate versus traditional transurethral resection of the prostate or transurethral plasmakinetic resection of prostate for benign prostatic obstruction: a systematic review and meta-analysis. World J Urol 2018; 36: 1355–64 CrossRef MEDLINE
e49.Lusuardi L, Mitterberger M, Hruby S, et al.: Update on the use of diode laser in the management of benign prostate obstruction in 2014. World J Urol 2015; 33: 555–62 CrossRef MEDLINE
e50.Roehrborn C, Barkin J, Gange SN, et al.: Five year results of the prospective randomized controlled prostatic urethral LIFT study. Can J Urol 2017; 24: 8802–13.
e51.Autorino R, Zargar H, Mariano MB, et al.: Perioperative outcomes of robotic and laparoscopic simple prostatectomy: a European-American multi-institutional analysis. Eur Urol 2015; 68: 86–94 CrossRef MEDLINE
e52.Lucca I, Shariat SF, Hofbauer SL, Klatte T: Outcomes of minimally invasive simple prostatectomy for benign prostatic hyperplasia: a systematic review and meta-analysis. World J Urol 2015; 33: 563–70 CrossRef MEDLINE
e53.Amparore D, De Cillis S, Volpi G, et al.: First- and second-generation temporary implantable nitinol devices as minimally invasive treatments for BPH-related LUTS: systematic review of the literature. Curr Urol Rep 2019; 20: 47 CrossRef MEDLINE
e54. Andriole GL, Kirby R: Safety and tolerability of the dual 5α-reductase inhibitor dutasteride in the treatment of benign prostatic hyperplasia. Eur Urol 2003; 44: 82–8 CrossRef

Info

Article