Clinical Practice Guideline
Infarction-related cardiogenic shock—diagnosis, monitoring and therapy
A German-Austrian S3 guideline
Dtsch Arztebl Int 2021; 118: 88-95. DOI: 10.3238/arztebl.m2021.0012
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For technical reasons, the English full text will be published approximately two weeks after the German print edition has been published.
* Leitliniengruppe siehe eKasten 1
Universitätsklinik und Poliklinik für Innere Medizin III, Universitätsklinikum Halle (Saale) der Martin-Luther-
Universität Halle-Wittenberg: Prof. Dr. med. Karl Werdan
Klinik für Kardiologie, Angiologie und internistische Intensivmedizin, St. Marien Krankenhaus Siegen: Prof. Dr. med.
Michael Buerke
Abteilung für
Kardiologie, Klinik Ottakring, Wiener Gesundheitsverbund, Wien: Univ.-Doz. Dr. med. Alexander Geppert
Universitätsklinik für Kardiologie, Herzzentrum Leipzig: Prof. Dr. med. Holger Thiele
Klinik für Anaesthesiologie, LMU Klinikum, München: Prof. Dr. med. Bernd Zwissler
Internisten am Maxplatz, Traunstein/Belegkardiologie Traunstein: Dr. med. Martin Ruß
Universitätsklinik und Poliklinik für Innere Medizin III, Universitätsklinikum Halle (Saale) der Martin-Luther-
Universität Halle-Wittenberg: Prof. Dr. med. Karl Werdan
Klinik für Kardiologie, Angiologie und internistische Intensivmedizin, St. Marien Krankenhaus Siegen: Prof. Dr. med.
Michael Buerke
Abteilung für
Kardiologie, Klinik Ottakring, Wiener Gesundheitsverbund, Wien: Univ.-Doz. Dr. med. Alexander Geppert
Universitätsklinik für Kardiologie, Herzzentrum Leipzig: Prof. Dr. med. Holger Thiele
Klinik für Anaesthesiologie, LMU Klinikum, München: Prof. Dr. med. Bernd Zwissler
Internisten am Maxplatz, Traunstein/Belegkardiologie Traunstein: Dr. med. Martin Ruß
1. | Scholz KH, Maier SKG, Maier LS, et al.: Impact of treatment delay on mortality in ST-segment elevation myocardial infarction (STEMI) patients presenting with and without haemodynamic instability: results from the German prospective, multicentre FITT-STEMI trial. Eur Heart J 2018; 39: 1065–74 CrossRef MEDLINE PubMed Central |
2. | Werdan K, Ruß M, Buerke M, Delle-Karth G, Geppert A, Schöndube FA: Cardiogenic shock due to myocardial infarction: diagnosis, monitoring and treatment. A German-Austrian S3 guideline. Dtsch Arztebl Int 2012; 109: 343–51 CrossRef MEDLINE PubMed Central |
3. | Zeymer U, Bueno H, Granger CB, et al.: Acute Cardiovascular Care Association position statement for the diagnosis and treatment of patients with acute myocardial infarction complicated by cardiogenic shock: a document of the Acute Cardiovascular Care Association of the European Society of Cardiology. EHJ Acute Cardiovasc Care 2020; 9: 183–97 CrossRef MEDLINE |
4. | Werdan K, Ruß M, Boeken U, et al: Infarkt-bedingter kardiogener Schock – Diagnose, Monitoring und Therapie. S3-Leitlinie. AWMF-RN 019–013. AWMF 2019. https://www.awmf.org/leitlinien/detail/ll/019-013.html (last accessed on 28 December 2020). |
5. | Thiele H, Ohman EM, de Waha-Thiele S, et al.: Management of cardiogenic shock complicating myocardial infarction: an update 2019. Eur Heart J 2019; 40: 2671–83 CrossRef MEDLINE |
6. | Bangalore S, Gupta N, Guo Y, et al.: Outcomes with invasive vs. conservative management of cardiogenic shock complicating acute myocardial infarction. Am J Med 2015; 128: 601–8 CrossRef MEDLINE |
7. | Thiele H, Akin I, Sandri M, et al.: PCI strategies in patients with acute myocardial infarction and cardiogenic shock. N Engl J Med 2017; 377: 2419–32 CrossRef MEDLINE |
8. | White HD, Assmann SF, Sanborn TA, et al.: Comparison of percutaneous coronary intervention and coronary artery bypass grafting after acute myocardial infarction complicated by cardiogenic shock: results from the should we emergently revascularize occluded coronaries for cardiogenic shock (SHOCK) trial. Circulation 2005; 112: 1992–2001 CrossRef MEDLINE |
9. | Zeymer U, Hochadel M, Karcher A-K, et al.: Procedural success rates and mortality in elderly patients with percutaneous coronary intervention for cardiogenic shock. JACC Cardiovasc Interv 2019; 12: 1853–9 CrossRef MEDLINE |
10. | Thiele H, Zeymer U, Neumann F-J, et al., for the IABP-SHOCK II Trial Investigators: Intraaortic balloon support for myocardial infarction with cardiogenic shock. N Engl J Med 2012; 367: 1287–96 CrossRef MEDLINE |
11. | Zeymer U, Schneider S, Zahn R, et al.: Impact of pre-hospital resuscitation on short- and long-term mortality in patients with cardiogenic shock undergoing revascularization: results of IABP-SHOCK study. J Am Coll Cardiol 2018; 71 (11 Suppl): 198 Presentation Number 1262–456 CrossRef |
12. | Michels G, Wengenmayer T, Hagl C, et al.: Empfehlungen zur extrakorporalen kardiopulmonalen Reanimation (eCPR): Konsensuspapier der DGIIN, DGK, DGTHG, DGfK, DGNI, DGAI, DIVI und GRC. Med Klin Intensivmed Notfmed 2018; 113: 478–86 CrossRef MEDLINE |
13. | Pichler P, Antretter H, Dünser M, et al.: Positionspapier der Österreichischen Kardiologischen Gesellschaft zum Einsatz der extrakorporalen Membranoxygenation (ECMO) bei Erwachsenen kardiologischen Patienten. Wien Klin Wochenschr 2015; 127: 169–84 CrossRef MEDLINE |
14. | Levy B, Clere-Jehl R, Legras A, et al.: Epinephrine versus norepinephrine for cardiogenic shock after acute myocardial infarction. J Am Coll Cardiol 2018; 72: 173–82 CrossRef MEDLINE |
15. | Prondzinsky R, Lemm H, Swyter M, et al.: Intra-aortic balloon counterpulsation in patients with acute myocardial infarction complicated by cardiogenic shock: the prospective, randomized IABP SHOCK trial for attenuation of multiorgan dysfunction syndrome. Crit Care Med 2010; 38: 152–60 CrossRef MEDLINE |
16. | Prondzinsky R, Unverzagt S, Russ M, et al.: Hemodynamic effects of intra-aortic balloon counterpulsation in patients with acute myocardial infarction complicated by cardiogenic shock: the prospective, randomized IABP SHOCK trial. Shock 2012; 37: 378–84 CrossRef MEDLINE |
17. | Unverzagt S, Buerke M, de Waha A, et al.: Intra-aortic balloon pump counter-pulsation (IABP) for myocardial infarction complicated by cardiogenic shock. Cochrane Database Syst Rev 2015; 3: CD007398 CrossRef MEDLINE |
18. | Schrage B, Ibrahim K, Loehn T, et al.: Impella support for acute myocardial infarction complicated by cardiogenic shock: a matched-pair IABP-SHOCK II trial 30-day mortality analysis. Circulation 2019; 139: 1249–58 CrossRef MEDLINE |
19. | Thiele H, Jobs A, Ouweneel DM, et al.: Percutaneous short-term active mechanical support devices in cardiogenic shock: a systematic review and collaborative meta-analysis of randomized trials. Eur Heart J 2017; 38: 3523–31 CrossRef MEDLINE |
20. | Tramm R, Ilic D, Davies AR, et al.: Extracorporeal membrane oxygenation for critically ill adults. Cochrane Database Syst Rev 2015; 1: CD010381 CrossRef MEDLINE PubMed Central |
21. | Ouweneel DM, Schotborgh JV, Limpens J, et al.: Extracorporeal life support during cardiac arrest and cardiogenic shock: a systematic review and meta-analysis. Intensive Care Med 2016; 42: 1922–34 CrossRef MEDLINE PubMed Central |
22. | Formica F, Mariani S, D’Alessanmdro S: Acute mechanical complications in patients suffering from acute myocardial infarction. Vessels Plus 2019; 3: 37 CrossRef |
23. | Schlotter F, de Waha S, Eitel I, et al.: Interventional post-myocardial infarction ventricular septal defect closure: a systematic review of current evidence. EuroIntervention 2016; 12: 94–102 CrossRef MEDLINE |
24. | Adamzik M, Bauer A, Bein T, et al.: Invasive Beatmung und Einsatz extrakorporaler Verfahren bei akuter respiratorischer Insuffizienz. S3-Leitlinie. AWMF-RN 001/021. 1th edition. Stand 05.12.2017. www.awmf.org/uploads/tx_szleitlinien/001-021l_S3_Invasive_Beatmung_2017-12.pdf (last accessed on 30 December 2020). |
25. | Guo L, Wang W, Zhao N, et al.: Mechanical ventilation strategies for intensive care unit patients without acute lung injury or acute respiratory distress syndrome: a systematic review and network meta-analysis. Crit Care 2016; 20: 226 CrossRef MEDLINE PubMed Central |
26. | Simonis G, Steiding K, Schaefer K, et al.: A prospective, randomized trial of continuous lateral rotation (”kinetic therapy”) in patients with cardiogenic shock. Clin Res Cardiol 2012; 101: 955–62 CrossRefMEDLINE |
27. | Dres M, Teboul JL, Monnet X: Weaning the cardiac patient from mechanical ventilation. Curr Opin Crit Care 2014; 20: 493–8 CrossRef MEDLINE |
28. | Lauridsen MD, Gammelager H, Schmidt M, et al.: Acute kidney injury treated with renal replacement therapy and 5-year mortality after myocardial infarction-related cardiogenic shock: a nationwide population-based cohort study. Crit Care 2015; 19: 452 CrossRef MEDLINE PubMed Central |
29. | Barilla F, Pannarale G, Torromeo C, et al.: Ivabradine in patients with ST-elevation myocardial infarction complicated by cardiogenic shock: a preliminary randomized prospective study. Clin Drug Investig 2016; 36: 849–56 CrossRef MEDLINE |
30. | Bjarnason-Wehrens B, Held K, Hoberg E, et al.: Deutsche Leitlinie zur Rehabilitation von Patienten mit Herz-Kreislauferkrankungen (DLL-KardReha). Clin Res Cardiol Supplements 2007; 2: III/1-III/54. Aktualisierung: S3–Leitlinie zur kardiologischen Rehabilitation (LL-KardReha) im deutschsprachigen Raum Europas. Deutschland, Österreich, Schweiz (D-A-CH), Langversion – Teil 1, 2019 AWMF-RN: 133/001, www.awmf.org/uploads/tx_szleitlinien/133-001k_S3-Kardiologische-Rehabilitation-in-D-A-CH_2020-12.pdf (last accessed on 12 December 2020) CrossRef |
31. | Thiele H, Zeymer U, Thelemann N, et al.: Intraaortic balloon pump in cardiogenic shock complicating acute myocardial infarction: long-term 6-year outcome of the randomized IABP-SHOCK II trial. Circulation 2019; 139: 395–403 CrossRef MEDLINE |
32. | Karagiannidis C, Windisch W: Epidemiologie und Mortalität der Herz- und Lungenersatzverfahren in Deutschland zwischen 2007 und 2014. (Letter). Med Klin Intensivmed Notfmed 2016; 111: 556–9 CrossRef MEDLINE |
33. | Van Diepen S, Hochman JS, Stebbins A, et al.: Association between delays in mechanical ventilation initiation and mortality in patients with refractory cardiogenic shock. JAMA Cardiol 2020; 5: 965– CrossRef MEDLINE |
34. | Schneck M, Hoder K, Gielen S, et al.: Lung protective ventilation and hospital survival of cardiac intensive care patients. Med Klin Intensivmed Notfmed 2016; 111: 508–13 CrossRef MEDLINE |
35. | Reintam Blaser A, Malbrain ML, Starkopf J, et al.: Gastrointestinal function in intensive care patients: terminology, definitions and management. Recommendations of the ESICM Working Group on Abdominal Problems. Intensive Care Med 2012; 38: 384–94 CrossRef MEDLINE PubMed Central |
36. | Werdan K, Boeken U, Briegel J, et al.: Infarktbedingter kardiogener Schock – Diagnose, Monitoring und Therapie. S3-Leitlinie. Intensiv- und Notfallbehandlung 2021; 46, in print. |
37. | Reignier J, Boisramé-Helms J, Brisard L, et al.: Enteral versus parenteral early nutrition in ventilated adults with shock: a randomised, controlled, multicentre, open-label, parallel-group study (NUTRIREA-2). Lancet 2018; 391: 133–43 CrossRef |
38. | Heyland D, Muscedere J, Wischmeyer PE, et al.: A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med 2013; 368: 1489–97 CrossRef MEDLINE |
39. | The PEPTIC Investigators for the Australian and New Zealnad Intensive Care Society Clinical Trials Group. Alberta Health Services Critical Care Strategic Clinical Network, and the Irish Critical Care Trials Group: Effect of stress ulcer prophylaxis with proton pump inhibitors vs histamine-2 receptor blockers on in-hospital mortality among ICU patients receiving invasive mechanical ventilation. The PEPTIC Randomized Clinical Trial. JAMA 2020; 323: 616–26 CrossRef MEDLINE PubMed Central |