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Real-world data are important to obtain a representative picture of the epidemiology of central venous catheter (CVC) infections (1). However, we would like to point out the following aspects: Since 251/8 104 catheters showed signs of infection (2), the catheter-associated infection rate is 3.1% (and not 1.4%). No distinction was made between short-term, tunneled CVCs and port systems, so that the risk of infection cannot be differentiated. A more detailed description of patient characteristics would also be helpful, since cancer patients with neutropenia have an increased risk of infection as compared to non-cancer patients (3). Bacteremias are more relevant than local CVC infections. However, the authors did not use the usual definition of a venous catheter-associated bloodstream infection (CABSI) (4), which limits the comparability of the results. In contrast to venous catheter-related bloodstream infections, CABSI does not describe the CVC as the source of infection, which means that CVC infections are overdiagnosed in patients with cancer (3). Finally, the CABSI point prevalence of 0.01% is only representative to a limited extent, as it depends on the total number of catheters and is therefore subject to fluctuations. In the SECRECY register (DRKS00006551; n = 3 898 CVCs), it is between 0% and 10% (on 15 May, for 2018 to 2021; unpublished data [Schalk E, 2021]).

DOI: 10.3238/arztebl.m2022.0035

PD Dr. med. Enrico Schalk

Medizinische Fakultät, Klinik für Hämatologie und Onkologie

Otto-von-Guericke-Universität Magdeburg, Magdeburg, Germany

enrico.schalk@med.ovgu.de

Prof. Dr. med. Marcus Hentrich

Abteilung für Innere Medizin III – Hämatologie und Onkologie

Rotkreuzklinikum München, Munich, Germany

Conflict of interest statement

PD Dr. Schalk has received speaker honoraria from Gilead Sciences.

Prof. Hentrich has received study support (third-party funds) for participation in the COAT trial from 3M.

1.
Schalk E, Teschner D, Hentrich M, et al.: Central venous catheter-related bloodstream infections in patients with hematological malignancies: comparison of data from a clinical registry and a randomized controlled trial. Infect Control Hosp Epidemiol 2020; 41: 254–56 CrossRef MEDLINE
2.
Bonsignore M, Tafelski S, Schwegmann K, Meier-Hellmann A, Witzke O, Nachtigall I: Risk factors for vascular catheter infections—findings of a point-prevalence study in 78 hospitals. Dtsch Arztebl Int 2021; 118: 503–4 CrossRef MEDLINE PubMed Central
3.
Böll B, Schalk E, Buchheidt D, et al.: Central venous catheter-related infections in hematology and oncology: 2020 updated guidelines on diagnosis, management, and prevention by the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO). Ann Hematol 2021; 100: 239–59 CrossRef MEDLINE PubMed Central
4.
KRINKO: Prävention von Infektionen, die von Gefäßkathetern ausgehen. Hinweise zur Blutkulturdiagnostik. Informativer Anhang 1 zur Empfehlung der Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) beim Robert Koch-Institut. Bundesgesundheitsbl 2017; 60: 216–30 CrossRef MEDLINE
1.Schalk E, Teschner D, Hentrich M, et al.: Central venous catheter-related bloodstream infections in patients with hematological malignancies: comparison of data from a clinical registry and a randomized controlled trial. Infect Control Hosp Epidemiol 2020; 41: 254–56 CrossRef MEDLINE
2.Bonsignore M, Tafelski S, Schwegmann K, Meier-Hellmann A, Witzke O, Nachtigall I: Risk factors for vascular catheter infections—findings of a point-prevalence study in 78 hospitals. Dtsch Arztebl Int 2021; 118: 503–4 CrossRef MEDLINE PubMed Central
3.Böll B, Schalk E, Buchheidt D, et al.: Central venous catheter-related infections in hematology and oncology: 2020 updated guidelines on diagnosis, management, and prevention by the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO). Ann Hematol 2021; 100: 239–59 CrossRef MEDLINE PubMed Central
4.KRINKO: Prävention von Infektionen, die von Gefäßkathetern ausgehen. Hinweise zur Blutkulturdiagnostik. Informativer Anhang 1 zur Empfehlung der Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) beim Robert Koch-Institut. Bundesgesundheitsbl 2017; 60: 216–30 CrossRef MEDLINE

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