Review article

Progeroid Syndromes

Clinical Symptoms and Molecular Causes of Premature Aging

Dtsch Arztebl 2007; 104(6): A-346

Hirschfeld, G; Berneburg, M; Arnim, C v; Iben, S; Ludolph, A C; Scharffetter-Kochanek, K

For technical reasons, the English full text will be published approximately two weeks after the German print edition has been published.

1. Ganten D, Ruckpaul K, Ruiz-Torres A, eds.: Molekularmedizinische Grundlagen von altersspezifischen Erkrankungen. Berlin: Springer 2004.
2. Gustin JF, Hisama FM, Weissman SM, Hrsg.: Chromosomal instability and aging: basic science and clinical implications. New York: Marcel Dekker 2003.
3. GENE-Reviews:
4. International Registry of Werner Syndrome:
5. Progeria Research Foundation:
6. Genetics Home Reference:
7. Martin GM: Genetic modulation of senescent phenotypes in homo sapiens. Cell 2005: 120: 523–32. MEDLINE
8. Kipling D, Davis T, Ostler EL, Faragher RG: What can progeroid syndromes tell us about human aging? Science 2004: 305: 1426–31. MEDLINE
9. Martin GM, Oshima J: Lessons from human progeroid syndromes. Nature 2000: 408: 263–6. MEDLINE
10. Cleaver JE: Cancer in xeroderma pigmentosum and related disorders of DNA repair. Nat Rev Cancer 2005: 5: 564–73. MEDLINE
11. Hoeijmakers JH: Genome maintenance mechanisms for preventing cancer. Nature 2001: 411: 366–74. MEDLINE
12. Andressoo JO, Hoeijmakers JH: Transcription-coupled repair and premature ageing. Mutat Res 2005: 577: 179–94. MEDLINE
13. Ljungman M, Lane DP: Transcription – guarding the genome by sensind DNA damage. Nat Rev Cancer 2004: 4: 727–37. MEDLINE
14. Hickson ID: RecQ helicases: caretakers of the genome. Nat Rev Cancer 2003: 3: 169–78. MEDLINE
15. Shiloh Y: ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 2003: 3: 155–68. MEDLINE
16. Pollex RL, Hegele RA: Hutchinson Gilford progeria syndrome. Clin Genet 2004: 66: 375–81. MEDLINE
17. Gruenbaum Y, Margalit A, Goldman RD, Shumaker DK, Wilson KL: The nuclear lamina comes of age. Nat Rev Mol Cell Biol 2005: 6: 21–31. MEDLINE
18. Taniguchi D, D`Andrea AD: Molecular pathogenesis of Fanconia anemia: recent progress. Blood 2006: 107: 4223–33.
19. Lombard DA, Chua KF, Mostovslavsky R, Franco S, Gostissa M, Alt FW: DNA repair, genome stability, and aging. Cell 2005; 120: 497–512. MEDLINE