| 1. | Ziegler AG, Hummel M, Schenker M, Bonifacio E: Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study. Diabetes 1999; 48: 460–8. |
| 2. | Hummel M, Bonifacio E, Schmid S, Walter M, Knopff A, Ziegler AG: Early appearance of islet autoantibodies predicts childhood type 1 diabets in offspring of diabetic parents. Ann Intern Med 2004; 140: 882–6. |
| 3. | Barker JM, Barriga KJ, Yu L et al.: Prediction of autoantibody positivity and progression to type 1 diabetes: Diabetes autoimmunity study in the young (DAISY). J Clin Endocrinol Metab 2004; 89: 3896–902. |
| 4. | Couper JJ, Steele C, Beresford S et al.: Lack of association between duration of breat-feeding or introduction of cow`s milk and development of islet autoimmunity. Diabetes 1999; 48: 2145–9. |
| 5. | Coleman DL, Kuzava JE, Leiter EH: Effect of diet on incidence of diabetes in nonobese diabetic mice. Diabetes 1990; 39: 432–6. |
| 6. | Hyppönen E, Läärä E, Reunanen A, Järvelin M-R, Virtanen SM: Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 2001; 358: 1500–3. |
| 7. | Virtanen SM, Räsänen L, Aro A et al.: Infant feeding in Finnish children < 7 yr of age with newly diagnosed IDDM. Diabetes Care 1991; 14: 415–7. |
| 8. | Stene LC, Joner G, and the Norwegian Childhood Diabetes Study Group: Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: a large, population-based, case-control study. Am J Clin Nutr 2003; 78: 1128–34. |
| 9. | Ziegler AG, Schmid S, Huber D, Hummel M, Bonifacio E: Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies. JAMA 2003; 290: 1721–8. |
| 10. | Norris JM, Barriga K, Klingensmith G et al.: Timing of initial cereal exposure in infancy and risk of islet autoimmunity. JAMA 2003; 290: 1713–20. |
| 11. | Bonifacio E, Ziegler AG, Hummel M et al.: Gluten: is it also a determinant of islet autoimmunity? Diabetes Metab Rev 1998; 14: 258–9. |
| 12. | Ventura A, Magazzu G, Greco L, SIGEP Study Group: Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. Gastroenterology 1999; 117: 297–303. |
| 13. | Mayer EJ, Hamman RF, Gay EC, Lezotte DC, Savitz DA, Klingensmith GJ: Reduced risk of IDDM among breast-fed children. The Colorado IDDM Registry. Diabetes 1988; 37: 1625–32. |
| 14. | Hummel M, Füchtenbusch M, Schenker M, Ziegler AG: No major association of breast-feeding, vaccinations, and childhood viral diseases with early islet autoimmunity in the German BABYDIAB Study. Diabetes Care 2000; 23: 969–74. |
| 15. | Norris JM, Beaty B, Klingensmith G et al.: Lack of association between early exposure to cow`s milk protein and beta-cell autoimmunity. Diabetes Autoimmunity Study in the Young (DAISY). JAMA 1996; 276: 609–14. |
| 16. | Akerblom HK, Virtanen SM, Ilonen J et al.: Dietary manipulation of beta cell autoimmunity in infants at increased risk of type 1 diabetes: a pilot study. Diabetologia 2005; 48: 829–37. |
| 17. | The EURODIAB Substudy 2 Study Group: Vitamin D supplement in early childhood and risk for type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1999; 42: 51–4. |
| 18. | Mathieu C, Waer M, Laureys J, Rutgeerts O, Bouillon R: Prevention of autoimmune diabetes in NOD mice by 1,25-dihydroxyvitamin D3. Diabetologia 1994; 37: 552–8. |
| 19. | Nettleton JA: Are n-3 fatty acids essential nutrients for fetal and infant development? J Am Diet Assoc 1993; 93: 58–64. |
| 20. | Delvin EE, Salle BL, Glorieux FH, Adeleine P, David LS: Vitamin D supplementation during pregnancy: effect on neonatal calcium homeostasis. J Pediatr 1986; 109: 328–34. |
| 21. | Stene LC, Ulriksen J, Magnus P, Joner G: Use of cod liver oil during pregnancy associated with lower risk of type 1 diabetes in the offspring. Diabetologia 2000; 43: 1093–8. |
| 22. | Virtanen SM, Jaakkola L, Räsänen L et al.: Nitrate and nitrite intake and the risk for type 1 diabetes in Finnish children. Diabet Med 1994; 11: 656–62. |
| 23. | Dahlquist GG, Blom LG, Persson LA, Sandstrom AI, Wall SG: Dietary factors and the risk of developing insulin dependent diabetes in childhood. BMJ 1990; 300: 1302–6. |
| 24. | Verge CF, Howard NJ, Irwig L, Simpson JM, Mackerras D, Silink M: Environmental factors in childhood IDDM. A population-based, case-control study. Diabetes Care 1994; 17: 1381–9. |
| 25. | Kostraba JN, Gay EC, Rewers M, Hamman RF: Nitrate levels in community drinking waters and risk of IDDM. Diabetes Care 1992: 15: 1505–8. |
| e1. | Virtanen SM, Knip M: Nutritional risk predictors of ß cell autoimmunity and type 1 diabetes at a young age. Am J Clin Nutr 2003; 78: 1053–67. |
| e2. | Knip M, Veijola R, Virtanen SM, Hyoty H, Vaarala O, Akerblom HK: Environmental triggers and determinants of type 1 diabetes environmental triggers and determinants of type 1 Diabetes. Diabetes 2005; 54: 125–36. |
| e3. | Knip M, Akerblom HK: Early nutrition and later diabetes risk. Adv Exp Med Biol 2005; 569: 142–50. |
| e4. | Vaarala O: The gut immune system and type 1 diabetes. Ann N Y Acad Sci 2002; 958: 39–46. |
| e5. | Robles DT, Eisenbarth GS: Type 1A diabetes induced by infection and immunization. J Autoimmun 2001; 16: 355–62. |
| e6. | Hummel M, Füchtenbusch M, Schenker M, Ziegler AG: No major association of breast feeding, vaccinations and common childhood viral disease with early islet autoimmunity in the German BABY-DIAB Study. Diabetes Care 2000; 23: 969–74. |
| e7. | Huppmann M, Baumgarten A, Ziegler AG, Bonifacio E: Neonatal bacille calmette-guerin vaccination and type 1 diabetes. Diabetes Care 2005; 28: 1204–6. |
| e8. | Parent ME, Siemiatycki J, Menzies R, Fritschi L, Colle E: Bacille calmette-guerin vaccination and incidence of IDDM in Montreal, Canada. Diabetes Care 1997; 20: 767–72. |
| e9. | Dahlquist G, Gothefors L: The cumulative incidence of childhood diabetes mellitus in Sweden unaffected by BCG-vaccination. Diabetologia 1995; 38: 873–4. |
| e10. | Funda DP, Kaas A, Bock T, Tlaskalova-Hogenova H, Buschard K: Gluten-free diet prevents diabetes in NOD mice. Diabetes Metab Res Rev 1999; 15: 323–7. |
| e11. | Perez-Bravo F, Carrasco E, Gutierrez-Lopez MD, Martinez MT, Lopez G, de los Rios MG: Genetic predisposition and environmental factors leading to the development of insulin-dependent diabetes mellitus in Chilean children. J Mol Med 1996; 74: 105–9. |
| e12. | Kostraba JN, Cruickshanks KJ, Lawler-Heavner J et al.: Early exposure to cow`s milk and solid foods in infancy, genetic predisposition, and risk of IDDM. Diabetes 1993; 42: 288–95. |
| e13. | Virtanen SM, Rasanen L, Ylonen K et al.: Early introduction of dairy products associated with increased risk of IDDM in Finnish children. The Childhood in Diabetess in Finland Study Group. Diabetes 1993; 42: 1786–90. |
| e14. | Hyppönen E, Kenward MG, Virtanen SM et al.: Infant feeding, early weight gain and risk of type 1 diabetes. Diabetes Care 1999; 22: 1961–5. |
| e15. | Meloni T, Marinaro AM, Mannazzu MC et al.: IDDM and early infant feeding. Sardinian case-control study. Diabetes Care 1997; 20: 340–2. |
| e16. | Auricchio R, Paparo F, Maglio M et al.: In vitro-deranged intestinal immune response to gliadin in type 1 diabetes. Diabetes 2004; 53: 1680–3. |
| e17. | Rocher A, Soriano F, Molina E, Gonzalez-Limas G, Mendez E: Characterization of distinct alpha- and gamma-type gliadins and low molecular weight components from wheat endosperm as coeliac immunoreactive proteins. Biochim Biophys Acta 1995; 1247: 143–8. |
| e18. | Hummel M, Bonifacio E, Stern M, Dittler J, Schimmel A, Ziegler AG: Development of celiac disease-associated antibodies in offspring of parents with type 1 diabetes. Diabetologia 2000; 43: 1005–11. |
| e19. | Cronin CC, Shanahan F: Insulin-dependent diabetes mellitus and coeliac disease. Lancet 1997; 349: 1096–7. |
| e20. | Not T, Tommasini A, Gonini G et al.: Undiagnosed coeliac disease and risk of autoimmune disorders in subjects with type 1 diabetes mellitus. Diabetologia 2001; 44: 151–5. |
| e21. | Mojibian M, Chakir H, MacFarlane AJ et al: Immune reactivity to a glb1 homologue in a highly wheat-sensitive patient with type 1 diabetes and celiac disease. Diabetes Care 2006; 29: 1108–10. |
| e22. | Koletzko S, Sherman P, Corey M, Griffiths A, Smith C: Role of infant feeding practices in Crohn`s disease in childhood. Br Med J 1989; 298: 1617–8. |
| e23. | Rigas A, Rigas B, Glassman M et al.: Breast-feeding and maternal smoking in the etiology of Crohn`s disease and ulcerative colitis in childhood. Ann Epidemiol 1993; 3: 387–92. |
| e24. | Greco L, Auricchio S, Mayer M, Grimaldi M: Case control study on nutritional risk factors in celiac disease. J Pediatr Gastroenterol Nutr 1988; 7: 395–9. |
| e25. | Kimpimaki T, Erkkola M, Korhonen S et al.: Short-term exclusive breastfeeding predisposes young children with increased genetic risk of type 1 diabetes to progressive beta-cell autoimmunity. Diabetologia 2001; 44: 63–6. |
| e26. | Munger KL, Zhang SM, O`Reilly E et al.: Vitamin D intake and incidence of multiple sclerosis. Neurology 2004; 62: 60–5. |
| e27. | Merlino LA, Curtis J, Mikuls TR, Cerhan JR, Criswell LA, Saag KG; Iowa Women`s Health Study: Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women`s Health Study. Arthritis Rheum 2004; 50: 72–7. |
| e28. | Cantorna MT, Mahon BD: D-hormone and the immune system. J Rheumatol Suppl 2005; 76: 11–20. |
| e29. | Lopez ER, Zwermann O, Segni M et al.: A promoter polymorphism of the CYP27B1 gene is associated with Addison's disease, Hashimoto's thyroiditis, Graves' disease and type 1 diabetes mellitus in Germans. Eur J Endocrinol 2004; 151: 193–7. |
| e30. | Saggese G, Federico G, Balestri M, Toniolo A: Calcitriol inhibits the PHA-induced production of IL-2 and IFN-gamma and the proliferation of human peripheral blood leukocytes while enhancing the surface expression of HLA class II molecules. J Endocrinol Invest 1989; 12: 329–35. |
| e31. | Mathieu C, Gysemans C, Giulietti A, Bouillon R: Vitamin D and diabetes. Diabetologia 2005; 48: 1247–57. |
| e32. | Hughes DA, Pinder AC: n-3 polyunsaturated fatty acids inhibit the antigen-presenting function of human monocytes. Am J Clin Nutr 2000; 171(Suppl): 357–60. |
| e33. | Endres S, Ghorbani R, Kelley VE et al.: The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells. N Engl J Med 1989; 320: 265–71. |
| e34. | Chase HP, Williams RL, Dupont J: Increased prostaglandin synthesis in childhood diabetes mellitus. J Pediatr 1979; 94: 185–9. |
| e35. | Litherland SA, Xie XT, Hutson AD et al.: Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus. J Clin Invest 1999; 104: 515–23. |
| e36. | Rakieten N, Rakieten ML, Nadkarni MR: Studies on the diabetogenic action of streptozotocin (NSC-37917). Cancer Chemother Rep 1963; 29: 91–8. |
| e37. | Wilander E, Gunnarsson R: Diabetogenic effects of n-nitrosomethylurea in the chinese hamster. Acta Pathol Microbiol Scand [A] 1975; 83: 206–12. |
| e38. | Toniolo A, Onodera T, Yoon JW, Notkins AL: Induction of diabetes by cumulative environmental insults from viruses and chemicals. Nature 1980; 288: 383–5. |
| e39. | Haglund B, Ryckenberg K, Selinus O, Dahlquist G: Evidence of a relationship between childhood-onset type 1 diabetes and low groundwater concentration of zinc. Diabetes Care 1996; 19: 873–5. |
| e40. | Stene LC, Hongve D, Magnus P, Ronningen KS, Joner G: Acidic drinking water and risk of childhood-onset type 1 diabetes. Diabetes Care 2002; 25: 1534–8. |
| e41. | Knekt P, Reunanen A, Marniemi J, Leino A, Aromaa A: Low vitamin E status is a potential risk factor for insulin-dependent diabetes mellitus. J Intern Med 1999; 245: 99–102. |
| e42. | Glatthaar C, Whittall DE, Welborn TA et al.: Diabetes in Western Australian children: descriptive epidemiology. Med J Aust 1988; 148: 117–23. |
| e43. | Elliot RB, Chase HP: Prevention or delay of type 1 (insulin-dependent) diabetes mellitus in children using nicotinamide. Diabetologia 1991; 34: 362–5. |
| e44. | Lampeter EF, Klinghammer A, Scherbaum WA et al.: The Deutsche Nicotinamide Intervention Study, an attempt to prevent type 1 diabetes. Diabetes 1998; 47: 980–4. |
| e45. | Virtanen SM, Hyppönen E, Läärä E et al.: Cow`s milk consumption, disease-associated autoantibodies and type 1 diabetes mellitus: a follow-up study in siblings of diabetic children. Diabet Med 1998; 15: 730–8. |
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