DÄ internationalArchive3/2008Conservative Treatment of Benign Prostatic Hyperplasia: The Use of Mucolytics

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Conservative Treatment of Benign Prostatic Hyperplasia: The Use of Mucolytics

Dtsch Arztebl Int 2008; 105(3): 53. DOI: 10.3238/arztebl.2008.0053a

Kirschfeld, K

LNSLNS The authors propose the use of alpha-blockers and 5 alpha-reductase inhibitors for the management of benign prostatic syndrome. As another group of substances for therapeutic use, I would suggest secretolytics and mucolytics. The prostate of elderly men often contains leukocyte permeated secretion masses in dilated glandular ducts (1). Mucoproteins are one of the constituents of prostatic secretion. In addition, the tissue pressure of the prostate is significantly increased in patients with chronic abacterial prostatitis (2). Elevated tissue pressure might conceivably be causally implicated in the pain associated with this condition. Mucoproteins are a constituent of prostatic secretion, and mucolytics could reduce the elevated tissue pressure. Mucoproteins contain disulfide bonds that can be cleaved by the free sulfhydryl group, for instance of the mucolytic agent acetylcysteine. In saliva, glycoproteins are depolymerized by cleavage of the disulfide bridges, which reduces the viscosity of the sputum. Should it also be possible to lower the viscosity of prostatic secretion by depolymerization of various components, outflow could be improved. After many years of suffering considerable symptoms of abacterial prostatitis, I took 2 x 600 mg ACC as a self-experiment. The symptoms improved within two hours and symptom remission was complete after two days. The PSA value normalized simultaneously (for details see my list of references: www.kyb.mpg.de). Secretolytics/mucolytics could conceivably also improve the symptoms of benign prostatic syndrome. DOI: 10.3238/arztebl.2008.0053a


Prof. Dr. rer. nat. Kuno Kirschfeld
Eduard-Spranger-Straße 57/9
72076 Tübingen, Germany

Conflict of interest statement
The author declares that no conflict of interest exists according to the guidelines of the International Committee of Medical Journal Editors.
1.
Hedinger CE, Dhom G: Pathologie des männlichen Genitale. Hoden, Prostata, Samenblasen. Berlin, Heidelberg, New York, London, Paris, Tokio, Hongkong, Barcelona: Springer-Verlag 1991.
2.
Documenta Geigy: Wissenschaftliche Tabellen. 7. Auflage, Basel: Ciba-Geigy AG 1968.
3.
Mehik A, Hellström P, Lukkarinen O et al.: Prostatic tissue pressure measurement as a possible diagnostic procedure in patients with chronic nonbacterial prostatitis/chronic pelvic pain syndrome. Urol Res 2000; 28: 316–8. MEDLINE
1. Hedinger CE, Dhom G: Pathologie des männlichen Genitale. Hoden, Prostata, Samenblasen. Berlin, Heidelberg, New York, London, Paris, Tokio, Hongkong, Barcelona: Springer-Verlag 1991.
2. Documenta Geigy: Wissenschaftliche Tabellen. 7. Auflage, Basel: Ciba-Geigy AG 1968.
3. Mehik A, Hellström P, Lukkarinen O et al.: Prostatic tissue pressure measurement as a possible diagnostic procedure in patients with chronic nonbacterial prostatitis/chronic pelvic pain syndrome. Urol Res 2000; 28: 316–8. MEDLINE

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