DÄ internationalArchive12/2008Aspirin Sensitive Asthma: Provocation Tests Do Not Work in Such Patients

Correspondence

Aspirin Sensitive Asthma: Provocation Tests Do Not Work in Such Patients

Dtsch Arztebl Int 2008; 105(12): 220. DOI: 10.3238/arztebl.2008.0220a

Frick, G

LNSLNS In response to the impressive scientific review article by Randerath and Galetke, we want to share our own experiences with the treatment of asthma and nasal polyps, in these times of increasing funding shortages, to show that there are simpler solutions to the problem. Small practices cannot present high case numbers or evidence-based study designs. We tested the tolerability of salix (willow) and acetylsalicylic acid (ASA) in 536 patients with allergies using electroacupuncture according to the method of Voll (EAV) in 115 patients with rhinoconjunctivitis and in 65 asthma patients with concomitant migraine or lipid metabolism disorders (1). Of those 180 patients 11 were affected, of whom two reacted to willow and ASA. They were successfully desensitized by using destructive interference (3). This method is used similarly for stimulants such as tree or grass pollen, house dust mites, eiderdown, and synthetic fibers, to prevent nasal polyps and subsequent aspirin sensitive asthma successfully.

The author has been using ASA at low dosages since 1985 after testing for thrombocyte hyperaggregability (2). Platelet agglutinating factor (PAF) is released in every allergic reaction and causes microcirculatory disruptions that may manifest as pain or shortness of breath.

Mast cells are activated not only by IgE but also by type III reactions (IgG). Immunocomplexes develop that activate complement pathways, thereby releasing slow reacting substances or leukotrienes. The simultaneously released heparin and similar glycosaminoglycans stimulate the matrix to release large basic proteins and arginine and lysine from eosinophils, which provides a stimulus to attract more eosinophils. These processes are disrupted by destructive interference, and the mast cell system can calm down.

We cannot accept Randerath and Galetke's statement: "Currently there is no reliable in-vitro method to diagnose aspirin sensitive asthma, so that provocation tests are vital". Our own clinical practice has shown that provocation tests do not work in such patients. We therefore need leukotriene antagonists for such patients only in the initial phase of their treatment. ASA does not have to present a real problem in practice.
DOI: 10.3238/arztebl.2008.0220a


Dr. med. habil. Gerhard Frick
Amtsstr. 11b
14469 Potsdam, Germany

Conflict of interest statement
The author declares that no conflict of interest exists according to the guidelines of the International Committee of Medical Journal Editors.
1.
Frick G: Effiziente Asthmabehandlung. Ärztezschr Naturheilverf 2005; 46: 433–7.
2.
Frick G, Frick U: Einige Beobachtungen zur Pathogenese und Therapie von Kopfschmerzsyndromen. Z Ärztl Fortbild 1986; 80: 19–21.
3.
Oschman JL: Energiemedizin. Konzepte und ihre wissenschaftliche Basis. München: Urban & Fischer 2006; 186.
1. Frick G: Effiziente Asthmabehandlung. Ärztezschr Naturheilverf 2005; 46: 433–7.
2. Frick G, Frick U: Einige Beobachtungen zur Pathogenese und Therapie von Kopfschmerzsyndromen. Z Ärztl Fortbild 1986; 80: 19–21.
3. Oschman JL: Energiemedizin. Konzepte und ihre wissenschaftliche Basis. München: Urban & Fischer 2006; 186.

Info

Specialities