DÄ internationalArchive12/2008Aspirin Sensitive Asthma: A Suitable Method Is Required

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Aspirin Sensitive Asthma: A Suitable Method Is Required

Dtsch Arztebl Int 2008; 105(12): 220. DOI: 10.3238/arztebl.2008.0220b

Schmidt, H

LNSLNS The authors classify aspirin sensitive asthma in connection with eosinophilia in the polyps themselves and in the tissues of the lower respiratory tract and with the obviously lacking formation of specific IgE antibodies as a non-allergy related process. Rather, they say that aspirin sensitive asthma is due to genetic disruptions of the arachidonic acid metabolic pathway, which results in overproduction of cysteinyl leukotrienes with subsequent overproduction of inflammatory mediators. In this process, the eosinophils are included only as the source, especially for LTC4 synthase; this does not do justice to the position of eosinophils in the immune system as per current knowledge. To detect eosinophils in tissue and peripheral blood circulation, the histocytochemical test for the enzyme phenoloxidase, after treatment with methanol, has proved to be suitable. Morphologically, the involvement of eosinophil granulocytes in cytotoxic as well as antibody forming reactions can be proved. Both types of reaction can occur simultaneously and can be triggered by medical drugs (1, 2, 3). DOI: 10.3238/arztebl.2008.0220b


Doz. Dr. med. habil. Dr. med. dent. Hans Schmidt
W.-Külz-Str. 32
04683 Naunhof, Germany

Conflict of interest statement
The author declares that no conflict of interest exists according to the guidelines of the International Committee of Medical Journal Editors.
1.
Schmidt H, Krell D, Krell R: Zur Pathogenese der Nasenschleimhautpolypen, untersucht mit dem histochemischen Nachweis für Phenoloxidase (EC 1.14.18.1). Acta histochem 1990; 89: 187–200.
2.
http://edoc.bibliothek.unihalle.de/servlets/DocumentServlet?id=117
3.
Ausschreibungs-Exemplare für den Langener Wissenschaftspreis 2007 des Paul-Ehrlich-Institus.
1. Schmidt H, Krell D, Krell R: Zur Pathogenese der Nasenschleimhautpolypen, untersucht mit dem histochemischen Nachweis für Phenoloxidase (EC 1.14.18.1). Acta histochem 1990; 89: 187–200.
2. http://edoc.bibliothek.unihalle.de/servlets/DocumentServlet?id=117
3. Ausschreibungs-Exemplare für den Langener Wissenschaftspreis 2007 des Paul-Ehrlich-Institus.

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