DÄ internationalArchive26/2008Congenital and Acquired Polycythemias: Testosterone Induced Polycythemias

Correspondence

Congenital and Acquired Polycythemias: Testosterone Induced Polycythemias

Dtsch Arztebl Int 2008; 105(26): 480; DOI: 10.3238/arztebl.2008.0480c

Nieschlag, E

This excellent review article omitted mentioning polycythemia due to testosterone, which is unfortunately gaining increasing importance. The article mentions the erythropoietic effects of doping with anabolic steroids and the resultant polycythemia, but the authors forgot that testosterone therapy in the treatment of hypogonadism can also lead to polycythemia. This affects mainly elderly men who are being treated for late onset hypogonadism (LOH) and overweight men with hypogonadism. Not only the dosage of testosterone, but also individual pharmacogenetics – due to an androgen receptor polymorphism – have a role in this context (1, 2).
DOI: 10.3238/arztebl.2008.0480c

Prof. Dr. med. Dr. h. c. Eberhard Nieschlag FRCP
Centrum für Reproduktionsmedizin und Andrologie
Universitätsklinikum Münster
Domagkstr. 11, 48149 Münster, Germany
eberhard.nieschlag@ukmuenster.de
1.
Coviello AD, Kaplan B, Lakshman KM, Chen T, Singh AB, Bhasin S: Effects of graded dose of testosterone on erythropoiesis in healthy young and older men. J Clin Endocrinol Metab 2008; 93: 914–9. MEDLINE
2.
Zitzmann M, Nieschlag E: Androgen receptor gene CAG repeat length and body mass index modulate the safety of long-term intramuscular testosterone undecanoate therapy in hypogonadal men. J Clin Endocrinol Metab 2007; 92: 3844–53. MEDLINE
1. Coviello AD, Kaplan B, Lakshman KM, Chen T, Singh AB, Bhasin S: Effects of graded dose of testosterone on erythropoiesis in healthy young and older men. J Clin Endocrinol Metab 2008; 93: 914–9. MEDLINE
2. Zitzmann M, Nieschlag E: Androgen receptor gene CAG repeat length and body mass index modulate the safety of long-term intramuscular testosterone undecanoate therapy in hypogonadal men. J Clin Endocrinol Metab 2007; 92: 3844–53. MEDLINE