szmtag Clinical Snapshot Shiitake Dermatitis (16.10.2020)
DÄ internationalArchive42/2020Clinical Snapshot Shiitake Dermatitis

Clinical Snapshot

Clinical Snapshot Shiitake Dermatitis

Dtsch Arztebl Int 2020; 117: 718. DOI: 10.3238/arztebl.2020.0718

Heineke, A; Mußgnug, H J; Tronnier, M


A 70-year-old man presented with an approximately 2-day history of itching striate skin lesions on the trunk and extremities with no general symptoms (Figure). On inquiry, he stated that he had eaten an Asian meal around 2 to 3 days before the onset of symptoms. He had consumed various fungi, including shiitake mushrooms. Shiitake dermatitis is described quite frequently in Asia, and the number of case reports in western countries is constantly increasing. Typically, the consumption of shiitake mushrooms is followed by a delayed striate cutaneous reaction resembling the flagellate dermatitis that can be induced by bleomycin (Latin flagellum: scourge, whip). The skin lesion is thought to represent a toxic reaction to the heat-labile protein lentinan; for this reason, the mushrooms should always be properly cooked before being eaten. Further allergological investigations such as skin tests or determination of specific IgE in serum bring no further benefit. Apart from bleomycin dermatitis, the differential diagnoses, depending on the clinical findings, include drug reactions or contact allergy. The recommended treatment is topical steroids, supplemented with antihistamines if required. The lesions usually resolve without scarring.

Dr. med. Andre Heineke, Dr. med. Hans Joachim Mußgnug, Prof. Dr. med. Michael Tronnier
Klinik für Dermatologie, Venerologie und Allergologie, Helios Klinikum Hildesheim,

Conflict of interest statement: The authors declare that no conflict of interest exists.

Translated from the original German by David Roseveare.

Cite this as: Heineke A, Mußgnug HJ, Tronnier M: Shiitake dermatitis. Dtsch Arztebl Int 2020; 117: 718. DOI: 10.3238/arztebl.2020.0718