DÄ internationalArchive47/2021Malignant Changes in the Hard Palate

Clinical Snapshot

Malignant Changes in the Hard Palate

Dtsch Arztebl Int 2021; 118: 813. DOI: 10.3238/arztebl.m2021.0083

Streit, E; Hassel, J C

LNSLNS

A 35-year-old man presented with changes in the mucosa of the hard palate. He reported that the tumor had appeared within the last 12 months and had never caused him any problems. There was a solid mass measuring 2.3 × 1.6 cm on the hard palate. There were also irregularly hyperpigmented maculae in the area immediately surrounding the tumor (Figure). Excision biopsy revealed melanoma of the mucosa, Breslow depth 5 mm. Preoperative staging showed no evidence of distant metastasis. The melanoma was completely excised by partial maxillectomy and subsequent upper jaw reconstruction. Twelve months after the successful tumor removal, multiple metastatic melanomas were found in the lungs, subcutaneously, and in the pancreas. Systemic therapy with the immune checkpoint blockers ipilimumab and nivolumab was unsuccessful. Malignant melanomas of the palate are extremely rare, often progress more aggressively than cutaneous melanomas, and are associated with poor prognosis. The patient died as a result of his mucosal melanoma 29 months after diagnosis.

Malignant Changes in the Hard Palate
Figure
Malignant Changes in the Hard Palate

Dr. med. Enrico Streit, Prof. Dr. med. Jessica C. Hassel, Uniklinik Heidelberg, Dermatologie, enrico.streit@med.uni-heidelberg.de

Conflict of interest statement: The authors declare that no conflict of interest exists.

Translated from the original German by Christine Rye.

Cite this as: Streit E, Hassel J: Malignant changes in the hard palate. Dtsch Arztebl Int 2021; 118: 813b. DOI: 10.3238/arztebl.m2021.0083

Malignant Changes in the Hard Palate
Figure
Malignant Changes in the Hard Palate