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Review article

The Epidemiology of Methicillin-Resistant Staphylococcus aureus (MRSA) in Germany

Dtsch Arztebl Int 2011; 108(45): 761-7. DOI: 10.3238/arztebl.2011.0761

Köck, R; Mellmann, A; Schaumburg, F; Friedrich, A W; Kipp, F; Becker, K

1. Köck R, Becker K, Cookson B, et al.: Methicillin-resistant Staphylococcus aureus (MRSA): burden of disease and control challenges in Europe. Euro Surveill 2010; 15(41): 19688. MEDLINE
2. Mielke M, Bölt U, Geffers C: Basisdaten der stationären Krankenversorgung in Deutschland – nosokomiale Infektionen. Epidemiologisches Bulletin 2010; 36: 359–68.
3. David MZ, Daum RS: Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic. Clin Microbiol Rev 2010; 23: 616–87. CrossRef MEDLINE
4. Löffler B, Hussain M, Grundmeier M, et al.: Staphylococcus aureus panton-valentine leukocidin is a very potent cytotoxic factor for
human neutrophils. PLoS Pathog 2010; 6: e1000715. CrossRef MEDLINE
5.Jappe U, Heuck D, Strommenger B, et al.: Staphylococcus aureus in dermatology outpatients with special emphasis on community-
associated methicillin-resistant strains. J Invest Dermatol 2008; 128: 2655–64. CrossRef MEDLINE
6. Tenhagen BA, Fetsch A, Stuhrenberg B, et al.: Prevalence of MRSA types in slaughter pigs in different German abattoirs. Vet Rec 2009; 165: 589–93. CrossRef MEDLINE
7. Bundesinstitut für Risikobewertung: Menschen können sich über den Kontakt mit Nutztieren mit Methicillin-resistenten Staphylococcus aureus (MRSA) infizieren. Stellungnahme 014/2009.
8. Spohr M, Rau J, Friedrich A, et al.: Methicillin-Resistant Staphylococcus aureus (MRSA) in three dairy herds in Southwest Germany. Zoonoses Public Health 2011; 58(4): 252–61. CrossRef MEDLINE
9. Cuny C, Nathaus R, Layer F, Strommenger B, Altmann D, Witte W: Nasal colonization of humans with methicillin-resistant Staphylococcus aureus (MRSA) CC398 with and without exposure to pigs. PLoS One 2009; 4: e6800. CrossRef MEDLINE
10. Köck R, Brakensiek L, Mellmann A, et al.: Cross-border comparison of the admission prevalence and clonal structure of meticillin-resistant Staphylococcus aureus. J Hosp Infect 2009; 71: 320–6. CrossRef MEDLINE
11. Robert Koch-Institut: FG Nosokomiale Infektionen des RKI: Auftreten und Verbreitung von MRSA in Deutschland 2008. Epidemiologisches Bulletin 2009; 17: 155–64.
12. Witte W, Mielke M: Community MRSA. Zentralbl Chir 2007; 132: 124–9. CrossRef MEDLINE
13. Reich-Schupke S, Geis G, Reising M, Altmeyer P, Stucker M: MRSA in dermatology – Prospective epidemiological study in employees and patients of a dermatological department of a university hospital. J Dtsch Dermatol Ges 2010; 8: 607–13. CrossRef MEDLINE
14. Grabe C, Buckard R, El-Ansari T, Käflein R: Flächendeckendes einmonatiges MRSA-Prävalenzscreening in Akut- und Rehakliniken in Siegen-Wittgenstein. Epidemiologisches Bulletin 2010; 18: 163–70.
15. Schulz M, Nonnenmacher C, Mutters R: Cost-effectiveness of rapid MRSA screening in surgical patients. Eur J Clin Microbiol Infect Dis 2009; 28: 1291–6. CrossRef MEDLINE
16. Woltering R, Hoffmann G, Daniels-Haardt I, Gastmeier P, Chaberny IF: Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in patients in long-term care in hospitals, rehabilitation centers and nursing homes of a rural district in Germany. Dtsch Med Wochenschr 2008; 133: 999–1003. CrossRef MEDLINE
17. Martin U, Sonntag AK, Neuhaus B, Karch H: Surface disinfection in nursing homes--what is really happening? Study of control success in three Duisburg nursing homes. Gesundheitswesen 2004; 66: 682–7. CrossRef MEDLINE
18. Daeschlein G, Assadian O, Rangous I, Kramer A: Risk factors for Staphylococcus aureus nasal carriage in residents of three nursing homes in Germany. J Hosp Infect 2006; 63: 216–20. CrossRef MEDLINE
19. Neuhaus B, Bocter N, Braulke C, Heuck D, Witte W: Studie zum Vorkommen von Methicillin-resistenten S. aureus in Alten- und Pflegeheimen in Nordrhein-Westfalen. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2002; 45: 894–904. CrossRef
20. Robert Koch-Institut: Nationales Referenzzentrum für Staphylokokken am RKI: Methicillin-resistente Staphylococcus aureus (MRSA) in deutschen Alten- und Pflegeheimen – zur Situation. Epidemiologisches Bulletin 2003; 19: 145–9.
21. von Baum H, Schmidt C, Svoboda D, Bock-Hensley O, Wendt C: Risk factors for methicillin-resistant Staphylococcus aureus carriage in residents of German nursing homes. Infect Control Hosp Epidemiol 2002; 23: 511–5. CrossRef MEDLINE
22. Höpken ME, Dreesman J, Braulke C, Heuck D, Witte W: MRSA Besiedlung in einem Alten- und Pflegeheim: Risikofaktoren und Prävalenz. Hyg Med 2001; 26: 225–30.
23. Heudorf U, Bremer V, Heuck D: Methicillin-resistant Staphylococcus aureus in long-term care facilities for the aged in Frankfurt am Main, Germany, in 1999. Gesundheitswesen 2001; 63: 447–54. CrossRef MEDLINE
24. Chaberny IF, Bindseil A, Sohr D, Gastmeier P: A point-prevalence study for MRSA in a German university hospital to identify patients at risk and to evaluate an established admission screening procedure. Infection 2008; 36: 526–32. CrossRef MEDLINE
25. Gastmeier P, Geffers C: Nosocomial infections in Germany. What are the numbers, based on the estimates for 2006? Dtsch Med Wochenschr 2008; 133: 1111–5.
CrossRef MEDLINE
e1. Kohlenberg A, Schwab F, Meyer E, Behnke M, Geffers C, Gastmeier P: Regional trends in multidrug-resistant infections in German intensive care units: a real-time model for epidemiological monitoring and analysis. J Hosp Infect 2009; 73: 239–45. CrossRef MEDLINE
e2. European Antimicrobial Resistance Surveillance System (EARSS): EARSS Annual Report 2008.
e3. Kresken M, Hafner D, Schmitz FJ, Wichelhaus TA, für die Studiengruppe Resistenzsituation bei klinisch wichtigen Infektionserregern gegenüber Antibiotika in Deutschland und im mitteleuropäischen Raum: Bericht über die Ergebnisse einer multizentrischen Studie der Arbeitsgemeinschaft Empfindlichkeitsprüfungen & Resistenz der Paul-Ehrlich-Gesellschaft für Chemotherapie e.V. aus dem Jahre 2007. Antiinfectives Intelligence, Rheinbach 2009.
e4. Kohlenberg A, Schwab F, Geffers C, Behnke M, Ruden H, Gastmeier P: Time-trends for Gram-negative and multidrug-resistant Gram-positive bacteria associated with nosocomial infections in German intensive care units between 2000 and 2005. Clin Microbiol Infect 2008; 14: 93–6. CrossRef MEDLINE
e5.Lessa FC, Mu Y, Davies J, et al.: Comparison of incidence of bloodstream infection with methicillin-resistant Staphylococcus aureus between England and United States, 2006–2007.
Clin Infect Dis 2010; 51: 925–8. CrossRef MEDLINE
e6. Nationales Referenzzentrum für Surveillance von nosokomialen Infektionen. Krankenhaus-Infektions-Surveillance-System: Modul MRSA-KISS Referenzdaten Berechnungszeitraum: 1st January 2009 - 31st Dezember 2009.
e7. Gillet Y, Issartel B, Vanhems P, et al.: Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients. Lancet 2002; 359: 753–9. CrossRef MEDLINE
e8. Hörnig-Franz I, Kahl BC, Tebbe W, et al.: Nekrotisierende Pneumonie mit Staphylococcus aureus (pvl-Gen positiv). Letal verlaufende Pneumonie bei einem 12-jährigen immunkompetenten Mädchen. Monatsschr Kinderheilkd 2007; 155: 10–15.
e9. Miller LG, Perdreau-Remington F, Rieg G, et al.: Necrotizing fasciitis caused by community-associated methicillin-resistant Staphylococcus aureus in Los Angeles. N Engl J Med 2005; 352: 1445–53. CrossRef MEDLINE
e10. von Eiff C, Friedrich AW, Peters G, Becker K: Prevalence of genes encoding for members of the staphylococcal leukotoxin family among clinical isolates of Staphylococcus aureus. Diagn Microbiol Infect Dis 2004; 49: 157–62. CrossRef MEDLINE
e11. Witte W, Strommenger B, Cuny C, Heuck D, Nuebel U: Methicillin-resistant Staphylococcus aureus containing the Panton-Valentine leucocidin gene in Germany in 2005 and 2006. J Antimicrob Chemother 2007; 60: 1258–63. CrossRef MEDLINE
e12. Fluegge K, Adams B, Luetke Volksbeck U, Serr A, Henneke P, Berner R: Low prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in a southwestern region of Germany. Eur J Pediatr 2006; 165: 688–90. CrossRef MEDLINE
e13. Wagenlehner FM, Naber KG, Bambl E, et al.: Management of a large healthcare-associated outbreak of Panton-Valentine leucocidin-positive meticillin-resistant Staphylococcus aureus in Germany. J Hosp Infect 2007; 67: 114–20. CrossRef MEDLINE
e14. Kola A, Hübschmann K,Behl ES, et al.: Hautabszesse bei Kindergartenkindern: Schwere Verläufe durch Panton-Valentine-Leukozidin-bildenden Staphylococcus aureus. Klin Padiatr 2010; 222: 319–20. CrossRef MEDLINE
e15. Vonberg RP, Sedlasek L, Chaberny IF, Suerbaum S, Gastmeier P, Linde HJ: Multiple Abszesse bei immunkompetenten Patienten durch Panton-Valentin-Leukozidin-positiven Staphylococcus aureus. Hautarzt 2008; 59: 319–22. CrossRef MEDLINE
e16. Witte W.: Zum Auftreten von caMRSA „USA300“ bei MSM in Deutschland. Epidemiologisches Bulletin 2008; 11: 85–94.
e17. Holzknecht BJ, Hardardottir H, Haraldsson G, et al.: Changing epidemiology of methicillin resistant Staphylococcus aureus in Iceland 2000–2008 challenges current guidelines. J Clin Microbiol 2010; 48(11): 4221–7. CrossRef MEDLINE
e18. Stenhem M, Ortqvist A, Ringberg H, et al.: Imported methicillin-resistant Staphylococcus aureus, Sweden. Emerg Infect Dis 2010; 16: 189–96. MEDLINE
e19. Longtin Y, Sudre P, Francois P, et al.: Community-associated methicillin-resistant Staphylococcus aureus: risk factors for infection, and long-term follow-up. Clin Microbiol Infect 2009; 15: 552–9. CrossRef MEDLINE
e20. Maier J, Melzl H, Reischl U, et al.: Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus in Germany associated with travel or foreign family origin. Eur J Clin Microbiol Infect Dis 2005; 24: 637–9. CrossRef MEDLINE
e21. Mollema FP, Richardus JH, Behrendt M, et al.: Transmission of methicillin-resistant Staphylococcus aureus to household contacts. J Clin Microbiol 2010; 48: 202–7. CrossRef MEDLINE
e22. Johansson PJ, Gustafsson EB, Ringberg H: High prevalence of MRSA in household contacts. Scand J Infect Dis 2007; 39: 764–8. CrossRef MEDLINE
e23. European Food Safety Authority: Analysis of the baseline survey on the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in holdings with breeding pigs, in the EU, 2008, Part A: MRSA prevalence estimates; on request from the European Commission. EFSA Journal 2009; 7: 1376.
e24. Köck R, Harlizius J, Bressan N, et al.: Prevalence and molecular characteristics of methicillin-resistant Staphylococcus aureus (MRSA) among pigs on German farms and import of livestock-related MRSA into hospitals. Eur J Clin Microbiol Infect Dis 2009; 28: 1375–82. CrossRef MEDLINE
e25. Fessler A, Scott C, Kadlec K, Ehricht R, Monecke S, Schwarz S: Characterization of methicillin-resistant Staphylococcus aureus ST398 from cases of bovine mastitis. J Antimicrob Chemother 2010; 65: 619–25. CrossRef MEDLINE
e26. Meemken D, Blaha T, Tegeler R, et al.: Livestock associated Methicillin-Resistant Staphylococcus aureus (LaMRSA) isolated from lesions of pigs at necropsy in Northwest Germany between 2004 and 2007. Zoonoses Public Health 2010; 57: e143–8. CrossRef MEDLINE
e27. Cuny C, Strommenger B, Witte W, Stanek C: Clusters of infections in horses with MRSA ST1, ST254, and ST398 in a veterinary hospital. Microb Drug Resist 2008; 14: 307–10. CrossRef MEDLINE
e28. van Duijkeren E, Moleman M, Sloet van Oldruitenborgh-Oosterbaan MM, et al.: Methicillin-resistant Staphylococcus aureus in horses and horse personnel: an investigation of several outbreaks. Vet Microbiol 2010; 141: 96–102. CrossRef MEDLINE
e29. Strommenger B, Kehrenberg C, Kettlitz C, Cuny C, Verspohl J, Witte W, et al.: Molecular characterization of methicillin-resistant Staphylococcus aureus strains from pet animals and their relationship to human isolates. J Antimicrob Chemother 2006; 57: 461–5. CrossRef MEDLINE
e30. Walther B, Wieler LH, Friedrich AW, et al.: Methicillin-resistant Staphylococcus aureus (MRSA) isolated from small and exotic animals at a university hospital during routine microbiological examinations. Vet Microbiol 2008; 127: 171–8. CrossRef MEDLINE
e31. Walther B, Wieler LH, Friedrich AW, Kohn B, Brunnberg L, Lübke-Becker A: Staphylococcus aureus and MRSA colonization rates among personnel and dogs in a small animal hospital: association with nosocomial infections. Berl Munch Tierarztl Wochenschr 2009; 122: 178–85. MEDLINE
e32. Cuny C, Friedrich A, Kozytska S, et al.: Emergence of methicillin-resistant Staphylococcus aureus (MRSA) in different animal species. Int J Med Microbiol 2010; 300: 109–17. CrossRef MEDLINE
e33. Grundmann H, Aanensen DM, van den Wijngaard CC, Spratt BG, Harmsen D, Friedrich AW: Geographic distribution of Staphylococcus aureus causing invasive infections in Europe: a molecular-epidemiological analysis. PLoS Med 2010; 7(1): e1000215. CrossRef MEDLINE
e34. Van Cleef B, Monnet D, Voss A, et al.: Livestock-associated methicillin-resistant Staphylococcus aureus from human samples, Europe, 2007. Emerg Infect Dis 2011; 17(3): 502–5. MEDLINE
e35. European Centre for Disease Prevention and Control, European Food Safety Agency, European Medicines Agency: Joint scientific report of ECDC, EFSA and EMEA on meticillin resistant Staphylococcus aureus (MRSA) in livestock, companion animals and foods.
e36. European Food Safety Authority (EFSA): Scientific Opinion of the Panel on Biological Hazards on a request from the European Commission on Assessment of the Public Health significance of meticillin resistant Staphylococcus aureus (MRSA) in animals and foods.
e37. Gastmeier P, Schwab F, Geffers C: MRSA-Reduktion auf KISS-Intensivstationen. Epidemiologisches Bulletin 2009; 29: 273–8.
e38. Trautmann M, Pollitt A, Loh U, et al.: Implementation of an intensified infection control program to reduce MRSA transmissions in a German tertiary care hospital. Am J Infect Control 2007; 35: 643–9. CrossRef MEDLINE
e39. Chaberny IF, Wriggers A, Behnke M, Gastmeier P: Antibiotics: MRSA prevention measures in German hospitals: results of a survey among hospitals, performed as part of the MRSA-KISS module. Dtsch Arztebl Int 2010; 107: 631–7. VOLLTEXT
e40. Friedrich AW: Vom Papier zur Realität: Chancen regionaler Netzwerkbildung für die Prävention von MRSA. Krankenhhygup2date 2010; 5: 105–20.
e41. Robert Koch-Institut FG Angewandte Infektions- und Krankenhaushygiene des RKI.: Regionale Netzwerke: Instrumente zur Vermeidung der Weiterverbreitung von Erregern mit speziellen Resistenzen und Multiresistenzen. Epidemiologisches Bulletin 2009; 12: 105–16.
e42. Robert Koch-Institut: Kommentar zu den „Empfehlungen zur Prävention und Kontrolle von MRSA-Stämmen in Krankenhäusern und anderen medizinischen Einrichtungen“. Epidemiologisches Bulletin 2008; 42: 363–4.
e43.Friedrich AW, Daniels-Haardt I, Köck R, et al.: EUREGIO MRSA-net Twente/Münsterland--a Dutch-German cross-border network for the prevention and control of infections caused by methicillin-resistant Staphylococcus aureus. Euro Surveill 2008; 13(35): pii: 18965. MEDLINE