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The Diagnosis and Treatment of Generalized Anxiety Disorder

Dtsch Arztebl Int 2013; 110(17): 300-10. DOI: 10.3238/arztebl.2013.0300

Bandelow, B; Boerner, R J; Kasper, S; Linden, M; Wittchen, H; Möller, H

CrossRef
1.Wittchen HU, Kessler RC, Beesdo K, Krause P, Hofler M, Hoyer J: Generalized anxiety and depression in primary care: prevalence, recognition, and management. J Clin Psychiatry 2002; 63(Suppl 8): 24–34. MEDLINE
2.Wittchen HU, Jacobi F: Size and burden of mental disorders in Europe—a critical review and appraisal of 27 studies. Eur Neuropsychopharmacol 2005; 15: 357–76. CrossRef MEDLINE
3.Wittchen HU, Jacobi F, Rehm J: The size and burden of mental disorders and other disorders of the brain in Europe 2010. Eur Neuropsychopharmacol 2011; 21: 655–79. CrossRef MEDLINE
4.Maier W, Linden M, Sartorius N: Psychische Erkrankungen in der Allgemeinpraxis. Ergebnisse und Schlußfolgerungen einer WHO-Studie. Dtsch Arztebl 1996; 93(18): 1202–6. VOLLTEXT
5.Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE: Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2005; 62: 593–602. CrossRef MEDLINE
6.Tyrer P, Seivewright H, Johnson T: The Nottingham Study of Neurotic Disorder: predictors of 12-year outcome of dysthymic, panic and generalized anxiety disorder. Psychol Med 2004; 34: 1385–94. CrossRef MEDLINE
7.Kessler RC, Frank RG, Edlund M, Katz SJ, Lin E, Leaf P: Differences in the use of psychiatric outpatient services between the United States and Ontario. N Engl J Med 1997; 336: 551–7. CrossRef MEDLINE
8.Bandelow B, Broocks A: Generalisierte Angststörungen – Hypothesen zur Ätiologie. In: Bandelow B (ed.): Angst- und Panikerkrankungen, 2nd edition. Bremen: UNI-MED, 2006: 105–8.
9.Noyes R Jr., Clarkson C, Crowe RR, Yates WR, McChesney CM: A family study of generalized anxiety disorder. Am J Psychiatry 1987; 144: 1019–24. MEDLINE
10.Hettema JM, Prescott CA, Kendler KS: A population-based twin study of generalized anxiety disorder in men and women. J Nerv Ment Dis 2001; 189: 413–20. CrossRef MEDLINE
11.Brawman-Mintzer O, Lydiard RB. Biological basis of generalized anxiety disorder. J Clin Psychiatry 1997;58:16–25; discussion 26. MEDLINE
12.Abelson JL, Glitz D, Cameron OG, Lee MA, Bronzo M, Curtis GC: Blunted growth hormone response to clonidine in patients with generalized anxiety disorder. Arch Gen Psychiatry 1991; 48: 157–62. CrossRef MEDLINE
13.Tiihonen J, Kuikka J, Rasanen P, Lepola U, et al.: Cerebral benzodiazepine receptor binding and distribution in generalized anxiety disorder: a fractal analysis. Mol Psychiatry 1997; 2: 463–71. CrossRef MEDLINE
14.Bandelow B, Zohar J, Hollander E, Kasper S, et al.: World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders – first revision. World J Biol Psychiatry 2008; 9: 248–312. CrossRef MEDLINE
15.Lader M: Dependence and withdrawal: comparison of the benzodiazepines and selective serotonin re-uptake inhibitors. Addiction 2012; 107: 909–10. CrossRef MEDLINE
16.Schweizer E, Rickels K, De Martinis N, Case G, Garcia-Espana F: The effect of personality on withdrawal severity and taper outcome in benzodiazepine dependent patients. Psychol Med 1998; 28: 713–20. CrossRef MEDLINE
17.Kan CC, Breteler MH, Zitman FG: High prevalence of benzodiazepine dependence in out-patient users, based on the DSM-III-R and ICD-10 criteria. Acta Psychiatr Scand 1997; 96: 85–93. CrossRef MEDLINE
18.Rickels K: Benzodiazepines in the treatment of anxiety. Am J Psychother 1982; 36: 358–70. MEDLINE
19.Donovan MR, Glue P, Kolluri S, Emir B: Comparative efficacy of antidepressants in preventing relapse in anxiety disorders—a meta-analysis. J Affect Disord 2010; 123: 9–16. CrossRef MEDLINE
20.Walendzik A, Lux G, Wasem J, Jahn R: Studie des Lehrstuhls für Medizinmanagement an der Universität Duisburg-Essen im Auftrag der Deutschen Psychotherapeuten-Vereinigung 2011.
21.Ballenger JC, Davidson JRT, Lecrubier Y, Nutt DJ, et al.: Consensus statement on generalized anxiety disorder from the international consensus group on depression and anxiety. Journal of Clinical Psychiatry 2001; 62(Suppl 11): 53–8. MEDLINE
22.DIMDI. ICD-10-GM 2009 – Systematisches Verzeichnis: Internationale statistische Klassifikation der Krankheiten und verwandter Gesundheitsprobleme – 10. Revision – German Modification. Deutsches Institut für Medizinische Dokumentation und Information (DIMIDI). In: Graubner B (eds.). Köln: Deutscher Ärzte-Verlag, 2008.
23.Sartorius N, Üstün TB, Costa e Silva JA, Goldberg D, et al.: An international study of psychological problems in primary care. Preliminary report from the World Health Organization Collaborative Project on ’Psychological Problems in General Health Care’. Arch Gen Psychiatry 1993; 50: 819–24. CrossRef MEDLINE
24.Wittchen HU, Kessler RC, Beesdo K, Krause P, Hofler M, Hoyer J: Generalized anxiety and depression in primary care: prevalence, recognition, and management. J Clin Psychiatry 2002; 63(Suppl 8): 24–34. MEDLINE
25.Sartorius N, Ustun TB, Lecrubier Y, Wittchen HU: Depression comorbid with anxiety: results from the WHO study on psychological disorders in primary health care. Br J Psychiatry Suppl 1996; 30: 38–43. MEDLINE
26.Bandelow B, Rudolf S, Reitt M, Wedekind D: Psychotherapie der Angsterkrankungen. In: Herpertz S, Schnell. K, Falkai P (eds.): Psychotherapie in der Psychiatrie. Stuttgart: Kohlhammer 2013.
27.Linden M: Generalisierte Angsterkrankungen. In: Batra A, Wassmann R, Buchkremer G, (eds.): Verhaltenstherapie. Grundlagen, Methoden, Anwendungsgebiete. Stuttgart: Thieme Verlag, 2012.
28.Baldwin DS, Stein DJ, Dolberg OT, Bandelow B: How long should a trial of escitalopram treatment be in patients with major depressive disorder, generalised anxiety disorder or social anxiety disorder? An exploration of the randomised controlled trial database. Hum Psychopharmacol 2009; 24: 269–75. CrossRef MEDLINE
e1. Brown TA, Marten PA, Barlow DH: Discriminant validity of the symptoms constituting the DSM-Iii-R and DSM-IV associated symptom criterion of generalized anxiety disorder. J Anxiety Disord 1995; 9: 317–28.
e2.Kessler RC, DuPont RL, Berglund P, Wittchen HU: Impairment in pure and comorbid generalized anxiety disorder and major depression at 12 months in two national surveys. Am J Psychiatry 1999; 156: 1915–23. MEDLINE
e3. Monk CS, Telzer EH, Mogg K, Bradley BP, et al.: Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder. Arch Gen Psychiatry 2008; 65: 568–76. CrossRef MEDLINE PubMed Central
e4. Blair K, Shaywitz J, Smith BW, et al.: Response to emotional expressions in generalized social phobia and generalized anxiety disorder: evidence for separate disorders. Am J Psychiatry 2008; 165: 1193–202. CrossRef MEDLINE PubMed Central
e5. Nitschke JB, Sarinopoulos I, Oathes DJ, et al.: Anticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment response. Am J Psychiatry 2009; 166: 302–10. CrossRef MEDLINE PubMed Central
e6. Schienle A, Ebner F, Schafer A: Localized gray matter volume abnormalities in generalized anxiety disorder. Eur Arch Psychiatry Clin Neurosci 2011; 261: 303–7. CrossRef MEDLINE
e7. Beck J: Praxis der Kognitiven Therapie. Weinheim: PVU 1999.
e8. Becker ES, Hoyer J: Generalisierte Angststörung. Göttingen: Hogrefe 2005.
e9.Wells A: Metacognitive therapy for anxiety and depression. Guildford 2009.
e10.Bandelow B, Rudolf S, Reitt M, Wedekind D: Angststörungen. In: Herpertz S, Schnell K, Falkai P (eds.): Psychotherapie in der Psychiatrie. Stuttgart: Kohlhammer 2013. PubMed Central
e11.Becker ES, Margraf J: Generalisierte Angststörung. Ein Therapieprogramm. Weinheim: Beltz 2002.
e12.Hoyer J, Beesdo K, Gloster AT, Runge J, Hofler M, Becker ES: Worry exposure versus applied relaxation in the treatment of generalized anxiety disorder. Psychother Psychosom 2009; 78: 106–15. CrossRef MEDLINE
e13. Lindsay WR, Gamsu CV, McLaughlin E, Hood EM, Espie CA: A controlled trial of treatments for generalized anxiety. Br J Clin Psychol 1987; 26: 3–15. CrossRef MEDLINE
e14. Butler G, Fennell M, Robson P, Gelder M: Comparison of behavior therapy and cognitive behavior therapy in the treatment of generalized anxiety disorder. J Consult Clin Psychol 1991; 59: 167–75. CrossRef MEDLINE
e15. Barlow DH, Rapee RM, Brown TA: Behavioral Treatment of Generalized Anxiety Disorder. Behavior Therapy 1992; 23: 551–70. CrossRef
e16.Ladouceur R, Dugas MJ, Freeston MH, Leger E, Gagnon F, Thibodeau N: Efficacy of a cognitive-behavioral treatment for generalized anxiety disorder: evaluation in a controlled clinical trial. J Consult Clin Psychol 2000; 68: 957–64. CrossRef MEDLINE
e17.Dugas MJ, Ladouceur R, Leger E, Freeston MH, et al.: Group cognitive-behavioral therapy for generalized anxiety disorder: treatment outcome and long-term follow-up. J Consult Clin Psychol 2003; 71: 821–5. CrossRef MEDLINE
e18.Mohlman J, Gorenstein EE, Kleber M, de Jesus M, Gorman JM, Papp LA: Standard and enhanced cognitive-behavior therapy for late-life generalized anxiety disorder: two pilot investigations. Am J Geriatr Psychiatry 2003; 11: 24–32. MEDLINE
e19.Dugas MJ, Brillon P, Savard P, Turcotte J, et al.: A randomized clinical trial of cognitive-behavioral therapy and applied relaxation for adults with generalized anxiety disorder. Behav Ther 2010; 41: 46–58. CrossRef MEDLINE PubMed Central
e20.Borkovec TD, Mathews AM, Chambers A, Ebrahimi S, Lytle R, Nelson R: The effects of relaxation training with cognitive or nondirective therapy and the role of relaxation-induced anxiety in the treatment of generalized anxiety. J Consult Clin Psychol 1987; 55: 883–8. CrossRef MEDLINE
e21.Borkovec TD, Costello E: Efficacy of applied relaxation and cognitive-behavioral therapy in the treatment of generalized anxiety disorder. J Consult Clin Psychol 1993; 61: 611–9. CrossRef MEDLINE
e22.Linden M, Zubraegel D, Baer T, Franke U, Schlattmann P: Efficacy of cognitive behaviour therapy in generalized anxiety disorders. Results of a controlled clinical trial (Berlin CBT-GAD Study). Psychother Psychosom 2005; 74: 36–42. CrossRef MEDLINE
e23.Power KG, Simpson RJ, Swanson V, Wallace LA: Controlled comparison of pharmacological and psychological treatment of generalized anxiety disorder in primary care. Br J Gen Pract 1990; 40: 289–94. MEDLINE PubMed Central
e24.Titov N, Andrews G, Robinson E, Schwencke G, et al.: Clinician-assisted Internet-based treatment is effective for generalized anxiety disorder: randomized controlled trial. Australian and New Zealand Journal of Psychiatry 2009; 43: 905–12. CrossRef
e25.Robinson E, Titov N, Andrews G, McIntyre K, Schwencke G, Solley K: Internet treatment for generalized anxiety disorder: a randomized controlled trial comparing clinician vs. technician assistance. PLoS One 2010; 5: e10942. CrossRef MEDLINE PubMed Central
e26.Paxling B, Almlov J, Dahlin M, Carlbring P, et al.: Guided internet-delivered cognitive behavior therapy for generalized anxiety disorder: a randomized controlled trial. Cogn Behav Ther 2011; 40: 159–73. CrossRef MEDLINE
e27.Andersson G, Paxling B, Roch-Norlund P, Ostman G, et al.: Internet-based psychodynamic versus cognitive behavioral guided self-help for generalized anxiety disorder: a randomized controlled trial. Psychother Psychosom 2012; 81: 344–55. CrossRef MEDLINE
e28.Luborsky L: Principles of Psychoanalytic Psychotherapy: A Manual for Supportive-Expressive (SE) Treatment New York: Basic Books, 1984.
e29.Crits-Christoph P, Wolf-Palacio D, Ficher M, Rudick D: Brief supportive-expressive psychodynamic therapy for generalized anxiety disorder. In: Barber JP, Crits-Christoph P, (eds.): Dynamic Therapies for Psychiatric Disorders. New York: Basic Books, 1995: 43–83.
e30.Leichsenring F, Leibing E: Supportive-Expressive (SE) Psychotherapy: An Update. Current Psychiatry Reviews 2007; 3: 57–64. CrossRef
e31.Durham RC, Murphy T, Allan T, Richard K, Treliving LR, Fenton GW: Cognitive therapy, analytic psychotherapy and anxiety management training for generalised anxiety disorder. Br J Psychiatry 1994; 165: 315–23. CrossRef MEDLINE
e32.Durham RC, Fisher PL, Treliving LR, Hau CM, Richard K, Steward JB: Psychotherapy and anxiety management training for generalized anxiety disorder: Symptom change, medication usage and attitudes to treatment. Behavioural and Cognitive Psychotherapy 1999; 27: 19–35.
e33.Leichsenring F, Salzer S, Jaeger U, Kachele H, et al.: Short-term psychodynamic psychotherapy and cognitive-behavioral therapy in generalized anxiety disorder: a randomized, controlled trial. Am J Psychiatry 2009; 166: 875–81. CrossRef MEDLINE
e34.Salzer S, Winkelbach C, Leweke F, Leibing E, Leichsenring F: Long-term effects of short-term psychodynamic psychotherapy and cognitive-behavioural therapy in generalized anxiety disorder: 12-month follow-up. Can J Psychiatry 2011; 56: 503–8. MEDLINE
e35.Allgulander C, Hackett D, Salinas E: Venlafaxine extended release (ER) in the treatment of generalised anxiety disorder: Twenty-four-week placebo-controlled dose-ranging study. Br J Psychiatry 2001; 179: 15–22. CrossRef MEDLINE
e36.Kasper S, Herman B, Nivoli G, van Ameringen M, et al.: Efficacy of pregabalin and venlafaxine-XR in generalized anxiety disorder: results of a double-blind, placebo-controlled 8-week trial. Int Clin Psychopharmacol 2009; 24: 87–96. CrossRef MEDLINE
e37.Serretti A, Chiesa A: Treatment-emergent sexual dysfunction related to antidepressants: a meta-analysis. J Clin Psychopharmacol 2009; 29: 259–66. CrossRef MEDLINE
e38.Hasnain M, W Victor RV, Hollett B: Weight gain and glucose dysregulation with second-generation antipsychotics and antidepressants: a review for primary care physicians. Postgrad Med 2012; 124: 154–67. CrossRef MEDLINE
e39.Davidson JR, Bose A, Korotzer A, Zheng H: Escitalopram in the treatment of generalized anxiety disorder: double-blind, placebo controlled, flexible-dose study. Depress Anxiety 2004; 19: 234–40. CrossRef MEDLINE
e40.Goodman WK, Bose A, Wang Q: Treatment of generalized anxiety disorder with escitalopram: pooled results from double-blind, placebo-controlled trials. J Affect Disord 2005; 87: 161–7. CrossRef MEDLINE
e41.Lenze EJ, Rollman BL, Shear MK, Dew MA, et al.: Escitalopram for older adults with generalized anxiety disorder: a randomized controlled trial. JAMA 2009; 301: 295–303. CrossRef MEDLINE PubMed Central
e42.Baldwin DS, Huusom AK, Maehlum E: Escitalopram and paroxetine in the treatment of generalised anxiety disorder: randomized, placebo-controlled, double-blind study. Br J Psychiatry 2006; 189: 264–72. CrossRef MEDLINE
e43.Merideth C, Cutler AJ, She F, Eriksson H: Efficacy and tolerability of extended release quetiapine fumarate monotherapy in the acute treatment of generalized anxiety disorder: a randomized, placebo controlled and active-controlled study. Int Clin Psychopharmacol 2012; 27: 40–54. CrossRef MEDLINE
e44.Bose A, Korotzer A, Gommoll C, Li D: Randomized placebo-controlled trial of escitalopram and venlafaxine XR in the treatment of generalized anxiety disorder. Depress Anxiety 2007.
e45.Allgulander C, Florea I, Huusom AK: Prevention of relapse in generalized anxiety disorder by escitalopram treatment. Int J Neuropsychopharmacol 2006; 9: 495–505. CrossRef MEDLINE
e46.Pollack MH, Zaninelli R, Goddard A, et al.: Paroxetine in the treatment of generalized anxiety disorder: results of a placebo-controlled, flexible-dosage trial. J Clin Psychiatry 2001; 62: 350–7. CrossRef MEDLINE
e47.Rickels K, Zaninelli R, McCafferty J, Bellew K, Iyengar M, Sheehan D: Paroxetine treatment of generalized anxiety disorder: a double-blind, placebo-controlled study. Am J Psychiatry 2003; 160: 749–56. CrossRef MEDLINE
e48.Stocchi F, Nordera G, Jokinen RH, Lepola UM, et al.: Efficacy and tolerability of paroxetine for the long-term treatment of generalized anxiety disorder. J Clin Psychiatry 2003; 64: 250–8. CrossRef MEDLINE
e49.Bielski RJ, Bose A, Chang CC: A double-blind comparison of escitalopram and paroxetine in the long-term treatment of generalized anxiety disorder. Ann Clin Psychiatry 2005; 17: 65–9. CrossRef MEDLINE
e50.Allgulander C, Dahl AA, Austin C, Morris PL, et al.: Efficacy of sertraline in a 12-week trial for generalized anxiety disorder. Am J Psychiatry 2004; 161: 1642–9. CrossRef MEDLINE
e51.Brawman-Mintzer O, Knapp RG, Rynn M, Carter RE, Rickels K: Sertraline treatment for generalized anxiety disorder: a randomized, double-blind, placebo-controlled study. J Clin Psychiatry 2006; 67: 874–81. CrossRef MEDLINE
e52.Ball SG, Kuhn A, Wall D, Shekhar A, Goddard AW: Selective serotonin reuptake inhibitor treatment for generalized anxiety disorder: a double-blind, prospective comparison between paroxetine and sertraline. J Clin Psychiatry 2005; 66: 94–9. CrossRef MEDLINE
e53.Rickels K, Pollack MH, Sheehan DV, Haskins JT: Efficacy of extended-release venlafaxine in nondepressed outpatients with generalized anxiety disorder. Am J Psychiatry 2000; 157: 968–74. CrossRef MEDLINE
e54.Nimatoudis I, Zissis NP, Kogeorgos J, Theodoropoulou S, Vidalis A, Kaprinis G: Remission rates with venlafaxine extended release in Greek outpatients with generalized anxiety disorder. A double-blind, randomized, placebo controlled study. Int Clin Psychopharmacol 2004; 19: 331–6. CrossRef MEDLINE
e55.Lenox-Smith AJ, Reynolds A: A double-blind, randomised, placebo controlled study of venlafaxine XL in patients with generalised anxiety disorder in primary care. Br J Gen Pract 2003; 53: 772–7. MEDLINE PubMed Central
e56.Hartford J, Kornstein S, Liebowitz M, Pigott T, et al.: Duloxetine as an SNRI treatment for generalized anxiety disorder: results from a placebo and active-controlled trial. Int Clin Psychopharmacol 2007; 22: 167–74. CrossRef MEDLINE
e57.Nicolini H, Bakish D, Duenas H, Spann M, et al.: Improvement of psychic and somatic symptoms in adult patients with generalized anxiety disorder: examination from a duloxetine, venlafaxine extended-release and placebo-controlled trial. Psychol Med 2009; 39: 267–76. CrossRef MEDLINE
e58.Montgomery SA, Tobias K, Zornberg GL, Kasper S, Pande AC: Efficacy and safety of pregabalin in the treatment of generalized anxiety disorder: a 6-week, multicenter, randomized, double-blind, placebo-controlled comparison of pregabalin and venlafaxine. J Clin Psychiatry 2006; 67: 771–82. CrossRef MEDLINE
e59.Davidson JR, DuPont RL, Hedges D, Haskins JT: Efficacy, safety, and tolerability of venlafaxine extended release and buspirone in outpatients with generalized anxiety disorder. J Clin Psychiatry 1999; 60: 528–35. CrossRef MEDLINE
e60.Gelenberg AJ, Lydiard RB, Rudolph RL, Aguiar L, Haskins JT, Salinas E: Efficacy of venlafaxine extended-release capsules in nondepressed outpatients with generalized anxiety disorder: A 6-month randomized controlled trial. JAMA 2000; 283: 3082–8. CrossRef MEDLINE
e61.Hackett D, Haudiquet V, Salinas E: A method for controlling for a high placebo response rate in a comparison of venlafaxine XR and diazepam in the short-term treatment of patients with generalised anxiety disorder. Eur Psychiatry 2003; 18: 182–7. CrossRef MEDLINE
e62.Koponen H, Allgulander C, Erickson J, Dunayevich E, et al.: Efficacy of Duloxetine for the Treatment of Generalized Anxiety Disorder: Implications for Primary Care Physicians. Prim Care Companion J Clin Psychiatry 2007; 9: 100–7. CrossRef MEDLINE PubMed Central
e63.Rynn M, Russell J, Erickson J, Detke MJ, et al.: Efficacy and safety of duloxetine in the treatment of generalized anxiety disorder: a flexible-dose, progressive-titration, placebo-controlled trial. Depress Anxiety 2008; 25: 182–9. CrossRef MEDLINE
e64.Allgulander C, Nutt D, Detke M, Erickson J, et al.: A non-inferiority comparison of duloxetine and venlafaxine in the treatment of adult patients with generalized anxiety disorder. J Psychopharmacol 2008; 22: 417–25. CrossRef MEDLINE
e65.Davidson JR, Wittchen HU, Llorca PM, Erickson J, et al.: Duloxetine treatment for relapse prevention in adults with generalized anxiety disorder: a double-blind placebo-controlled trial. Eur Neuropsychopharmacol 2008; 18: 673–81. CrossRef MEDLINE
e66.Pohl RB, Feltner DE, Fieve RR, Pande AC: Efficacy of pregabalin in the treatment of generalized anxiety disorder: double-blind, placebo-controlled comparison of BID versus TID dosing. J Clin Psychopharmacol 2005; 25: 151–8. CrossRef MEDLINE
e67.Pande AC, Crockatt JG, Feltner DE, Janney CA, et al.: Pregabalin in generalized anxiety disorder: a placebo-controlled trial. Am J Psychiatry 2003; 160: 533–40. CrossRef MEDLINE
e68.Feltner DE, Crockatt JG, Dubovsky SJ, Cohn CK, et al.: A randomized, double-blind, placebo-controlled, fixed-dose, multicenter study of pregabalin in patients with generalized anxiety disorder. J Clin Psychopharmacol 2003; 23: 240–9. CrossRef MEDLINE
e69.Rickels K, Pollack MH, Feltner DE, Lydiard RB, et al.: Pregabalin for treatment of generalized anxiety disorder: a 4-week, multicenter, double-blind, placebo-controlled trial of pregabalin and alprazolam. Arch Gen Psychiatry 2005; 62: 1022–30. CrossRef MEDLINE
e70.Feltner D, Wittchen HU, Kavoussi R, Brock J, Baldinetti F, Pande AC: Long-term efficacy of pregabalin in generalized anxiety disorder. Int Clin Psychopharmacol 2008; 23: 18–28. CrossRef MEDLINE
e71.Hoehn-Saric R, McLeod DR, Zimmerli WD: Differential effects of alprazolam and imipramine in generalized anxiety disorder: somatic versus psychic symptoms. J Clin Psychiatry 1988; 49: 293–301. MEDLINE
e72.Rickels K, Downing R, Schweizer E, Hassman H: Antidepressants for the treatment of generalized anxiety disorder. A placebo-controlled comparison of imipramine, trazodone, and diazepam. Arch Gen Psychiatry 1993; 50: 884–95. CrossRef MEDLINE
e73.Elie R, Lamontagne Y: Alprazolam and diazepam in the treatment of generalized anxiety. J Clin Psychopharmacol 1984; 4: 125–9. CrossRef MEDLINE
e74.Enkelmann R: Alprazolam versus buspirone in the treatment of outpatients with generalized anxiety disorder. Psychopharmacology 1991; 105: 428–32. CrossRef MEDLINE
e75.Lydiard RB, Ballenger JC, Rickels K: A double-blind evaluation of the safety and efficacy of abecarnil, alprazolam, and placebo in outpatients with generalized anxiety disorder. Abecarnil Work Group. J Clin Psychiatry 1997; 58 Suppl 11: 11–8. MEDLINE
e76.Möller HJ, Volz HP, Reimann IW, Stoll KD: Opipramol for the treatment of generalized anxiety disorder: a placebo-controlled trial including an alprazolam-treated group. J Clin Psychopharmacol 2001; 21: 59–65. CrossRef MEDLINE
e77.Fontaine R, Annable L, Chouinard G, Ogilvie RI: Bromazepam and diazepam in generalized anxiety: a placebo-controlled study with measurement of drug plasma concentrations. J Clin Psychopharmacol 1983; 3: 80–7. CrossRef MEDLINE
e78.Ansseau M, Olie JP, von Frenckell R, Jourdain G, Stehle B, Guillet P: Controlled comparison of the efficacy and safety of four doses of suriclone, diazepam, and placebo in generalized anxiety disorder. Psychopharmacology (Berl) 1991; 104: 439–43. CrossRef MEDLINE
e79.Rickels K, Schweizer E, DeMartinis N, Mandos L, Mercer C: Gepirone and diazepam in generalized anxiety disorder: a placebo-controlled trial. J Clin Psychopharmacol 1997; 17: 272–7. CrossRef MEDLINE
e80.Boyer WF, Feighner JP: A placebo-controlled double-blind multicenter trial of two doses of ipsapirone versus diazepam in generalized anxiety disorder. Int Clin Psychopharmacol 1993; 8: 173–6. CrossRef MEDLINE
e81.Rickels K, DeMartinis N, Aufdembrinke B: A double-blind, placebo-controlled trial of abecarnil and diazepam in the treatment of patients with generalized anxiety disorder. J Clin Psychopharmacol 2000; 20: 12–8. CrossRef MEDLINE
e82.Feighner JP, Merideth CH, Hendrickson GA: A double-blind comparison of buspirone and diazepam in outpatients with generalized anxiety disorder. J Clin Psychiatry 1982; 43: 103–8. MEDLINE
e83.Jacobson AF, Dominguez RA, Goldstein BJ, Steinbook RM: Comparison of buspirone and diazepam in generalized anxiety disorder. Pharmacotherapy 1985; 5: 290–6. MEDLINE
e84.Ross CA, Matas M: A clinical trial of buspirone and diazepam in the treatment of generalized anxiety disorder. Can J Psychiatry 1987; 32: 351–5. MEDLINE
e85.Llorca PM, Spadone C, Sol O, Danniau A, et al.: Efficacy and safety of hydroxyzine in the treatment of generalized anxiety disorder: a 3-month double-blind study. J Clin Psychiatry 2002; 63: 1020–7. CrossRef MEDLINE
e86.Pollack MH, Worthington JJ, Manfro GG, Otto MW, Zucker BG: Abecarnil for the treatment of generalized anxiety disorder: a placebo-controlled comparison of two dosage ranges of abecarnil and buspirone. J Clin Psychiatry 1997; 58 Suppl 11: 19–23. MEDLINE
e87.Rickels K, Weisman K, Norstad N, Singer M, et al.: Buspirone and diazepam in anxiety: a controlled study. J Clin Psychiatry 1982; 43: 81–6. MEDLINE
e88.Strand M, Hetta J, Rosen A, Sorensen S, et al.: A double-blind, controlled trial in primary care patients with generalized anxiety— a Comparison between Buspirone and Oxazepam. Journal of Clinical Psychiatry 1990; 51: 40–5. MEDLINE
e89.Lader M, Scotto JC: A multicentre double-blind comparison of hydroxyzine, buspirone and placebo in patients with generalized anxiety disorder. Psychopharmacology-Berl 1998; 139: 402–6. CrossRef MEDLINE
e90.Darcis T, Ferreri M, Natens J, Burtin B, Deram P: A multicentre double-blind placebo-controlled study investigating the anxiolytic efficacy of hydroxyzine in patients with generalized anxiety. Human Psychopharmacology: Clinical and Experimental 1995; 10: 181–7. CrossRef
e91.Ferreri M, Hantouche EG, Billardon M: Interêt de l’hydroxyzine dans le trouble anxiété géneralisée: étude contrôle en double aveugle versus placebo. Encéphale 1994; 20: 785–91. MEDLINE
e92.Khan A, Joyce M, Atkinson S, Eggens I, Baldytcheva I, Eriksson H: A randomized, double-blind study of once-daily extended release Quetiapine Fumarate (Quetiapine XR) Monotherapy in patients with generalized anxiety disorder. J Clin Psychopharmacol 2011; 31: 418–28. CrossRef MEDLINE
e93.Bandelow B, Chouinard G, Bobes J, Ahokas A, et al.: Extended-release quetiapine fumarate (quetiapine XR): a once-daily monotherapy effective in generalized anxiety disorder. Data from a randomized, double-blind, placebo- and active-controlled study. Int J Neuropsychopharmacol 2010; 13: 305–20. CrossRef MEDLINE
e94.Katzman MA, Brawman-Mintzer O, Reyes EB, Olausson B, Liu S, Eriksson H: Extended release quetiapine fumarate (quetiapine XR) monotherapy as maintenance treatment for generalized anxiety disorder: a long-term, randomized, placebo-controlled trial. Int Clin Psychopharmacol 2011; 26: 11–24. CrossRef MEDLINE
e95.Magi K, Mezhebovsky I, She F, Datto C, Eriksson HA: Efficacy and tolerability of extended release quetiapine fumarate (quetiapine XR) monotherapy in elderly patients with generalised anxiety disorder (GAD) (Poster). World J Biol Psychiatry 2009; 10: 239.
e96.Altamura AC, Serati M, Buoli M, Dell’Osso B: Augmentative quetiapine in partial/nonresponders with generalized anxiety disorder: a randomized, placebo-controlled study. Int Clin Psychopharmacol 2011; 26: 201–5. CrossRef MEDLINE
e97.Stein DJ, Ahokas AA, de Bodinat C: Efficacy of agomelatine in generalized anxiety disorder: a randomized, double-blind, placebo-controlled study. J Clin Psychopharmacol 2008; 28: 561–6. CrossRef MEDLINE
e98.Stein DJ, Ahokas A, Albarran C, Olivier V, Allgulander C: Agomelatine prevents relapse in generalized anxiety disorder: a 6-month randomized, double-blind, placebo-controlled discontinuation study. J Clin Psychiatry 2012; 73: 1002–8. CrossRef MEDLINE
e99.Woelk H, Schläfke S: A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder. Phytomedicine 2010; 17: 94–9. CrossRef MEDLINE
e100.Kasper S, Gastpar M, Muller WE, et al.: Efficacy and safety of silexan, a new, orally administered lavender oil preparation, in subthreshold anxiety disorder – evidence from clinical trials. Wien Med Wochenschr 2010; 160: 547–56. CrossRef MEDLINE
e101.Kasper S, Gastpar M, Muller WE, et al.: Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of ’subsyndromal’ anxiety disorder: a randomized, double-blind, placebo controlled trial. Int Clin Psychopharmacol 2010; 25: 277–87. CrossRef MEDLINE
e102.Bonne O, Shemer Y, Gorali Y, Katz M, Shalev AY: A randomized, double-blind, placebo-controlled study of classical homeopathy in generalized anxiety disorder. J Clin Psychiatry 2003; 64: 282–7. CrossRef MEDLINE
e103.Montgomery S, Chatamra K, Pauer L, Whalen E, Baldinetti F: Efficacy and safety of pregabalin in elderly people with generalised anxiety disorder. Br J Psychiatry 2008; 193: 389–94. CrossRef MEDLINE
e104.Davidson J, Allgulander C, Pollack MH, et al.: Efficacy and tolerability of duloxetine in elderly patients with generalized anxiety disorder: a pooled analysis of four randomized, double-blind, placebo-controlled studies. Hum Psychopharmacol 2008; 23: 519–26. CrossRef MEDLINE
e105.Katz IR, Reynolds CF 3rd, Alexopoulos GS, Hackett D: Venlafaxine ER as a treatment for generalized anxiety disorder in older adults: pooled analysis of five randomized placebo-controlled clinical trials. J Am Geriatr Soc 2002; 50: 18–25. CrossRef MEDLINE
e106.Stanley MA, Beck JG, Novy DM, Averill PM, et al.: Cognitive-behavioral treatment of late-life generalized anxiety disorder. J Consult Clin Psychol 2003; 71: 309–19. CrossRef MEDLINE
e107.Stanley MA, Beck JG, Glassco JD: Treatment of generalized anxiety in older adults: A preliminary comparison of cognitive-behavioral and supportive approaches. Behavior Therapy 1996; 27: 565–81. CrossRef
e108.Stanley MA, Wilson NL, Novy DM, et al.: Cognitive behavior therapy for generalized anxiety disorder among older adults in primary care: a randomized clinical trial. Jama 2009; 301: 1460–7. CrossRef MEDLINE PubMed Central
e109.Wetherell JL, Gatz M, Craske MG: Treatment of generalized anxiety disorder in older adults. Journal of Consulting and Clinical Psychology 2003; 71: 31–40. CrossRef MEDLINE
e110.Wittchen HU, Kessler RC, Beesdo K, Krause P, Hofler M, Hoyer J: Generalized anxiety and depression in primary care: prevalence, recognition, and management. J Clin Psychiatry 2002; 63 Suppl 8: 24–34. MEDLINE
e111.Rickels K, Shiovitz TM, Ramey TS, Weaver JJ, Knapp LE, Miceli JJ: Adjunctive therapy with pregabalin in generalized anxiety disorder patients with partial response to SSRI or SNRI treatment. Int Clin Psychopharmacol 2012; 27: 142–50. CrossRef MEDLINE
e112.Pollack MH, Simon NM, Zalta AK, et al.: Olanzapine augmentation of fluoxetine for refractory generalized anxiety disorder: a placebo controlled study. Biol Psychiatry 2006; 59: 211–5. CrossRef MEDLINE