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Review article

The Treatment of Chronic Recurrent Oral Aphthous Ulcers

Dtsch Arztebl Int 2014; 111: 665-73. DOI: 10.3238/arztebl.2014.0665

Altenburg, A; El-Haj, N; Micheli, C; Puttkammer, M; Abdel-Naser, M; Zouboulis, C C

1.Altenburg A, Krahl D, Zouboulis CC: Nicht-infektiöse exulzerierende Mundschleimhauterkrankungen. J Dtsch Dermatol Ges 2008; 7: 242–57. CrossRef CrossRef MEDLINE
2.Bork K, Burgdorf W, Hoede N: Mundschleimhaut und Lippenkrankheiten. 3rd edition. Stuttgart: Schattauer 2008; 49–58.
3.Rogers RS 3rd: Complex aphthosis. Adv Exp Med Biol 2003; 528: 311–6. CrossRef MEDLINE
4.Hornstein OP: Aphthen und aphthoide Läsionen der Mundschleimhaut. HNO 1998; 46: 102–11. CrossRef MEDLINE
5.Kleinman DV, Swango PA, Pindborg JJ: Epidemiology of oral mucosal lesions in United States schoolchildren: 1986–87. Community Dent Oral Epidemiol 1994; 22: 243–53. CrossRef MEDLINE
6.Altenburg A, Abdel-Naser MB, Abdallah M, Seeber H, Zouboulis CC: Practical aspects of management of recurrent aphthous stomatitis. J Eur Acad Dermatol Venereol 2007; 21: 1019–26. CrossRef MEDLINE
7.Chavan M, Jain H, Diwan N, Khedkar S, Shete A, Durkar S:
Recurrent aphthous stomatitis: a review. J Oral Pathol Med 2012; 41: 577–83. CrossRef MEDLINE
8.Altenburg A, Mahr A, Maldini C, et al.: Epidemiologie und Klinik des Morbus Adamantiades-Behçet in Deutschland: Aktuelle Daten. Ophthalmologe 2012; 109: 531–41. CrossRef MEDLINE
9.International Team for the Revision of the International Criteria for Behçet’s Disease (ITR-ICBD): The International Criteria for Behçet’s Disease (ICBD): a collaborative study of 27 countries on the
sensitivity and specificity of the new criteria. J Eur Acad Dermatol Venereol 2014; 28: 338–47. CrossRef MEDLINE
10.Shim Y, Choi JH, Ahn HJ, Kwon JS: Effect of sodium lauryl sulfate on recurrent aphthous stomatitis: a randomized controlled clinical trial. Oral Dis 2012; 18: 655–60. CrossRef MEDLINE
11.Descroix V, Coudert AE, Vigé A, et al.: Efficacy of topical 1 %
lidocaine in the symptomatic treatment of pain associated with oral mucosal trauma or minor oral aphthous ulcer: a randomized, double-blind, placebo-controlled, parallel-group, single-dose study. J Orofac Pain 2011; 25: 327–32. MEDLINE
12.Skaare AB, Herlofson BB, Barkvoll P: Mouthrinses containing triclosan reduce the incidence of recurrent aphthous ulcers (RAU). J Clin Periodontol 1996; 23: 778–81. CrossRef MEDLINE
13.Saxen MA, Ambrosius WT, al Rehemtula KF, Russell AL, Eckert GJ: Sustained relief of oral aphthous ulcer pain from topical diclofenac in hyaluronan: a randomized, double-blind clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997; 84: 356–61. CrossRef MEDLINE
14.Bonitsis NG, Altenburg A, Krause L, Stache T, Zouboulis CC: Current concepts in the treatment of Adamantadies-Behçet’s disease. Drugs Future 2009; 34: 749–63.
15.Alidaee MR, Taheri A, Mansoori P, Ghodsi SZ: Silver nitrate cautery in aphthous stomatitis: a randomized controlled trial. Br J Dermatol 2005; 153: 521–5. CrossRef MEDLINE
16.Zand N, Ataie-Fashtami L, Djavid GE, et al.: Relieving pain in minor aphthous stomatitis by a single session of non-thermal carbon dioxide laser irradiation. Lasers Med Sci 2009; 24: 515–20. CrossRef MEDLINE
17.Arabaci T, Kara C, Ciçek Y: Relationship between periodontal parameters and Behçet’s disease and evaluation of different treatments for oral recurrent aphthous stomatitis. J Periodontal Res 2009; 44: 718–25. CrossRef MEDLINE
18.Henricsson V, Axéll T: Treatment of recurrent aphthous ulcers with aureomycin mouth rinse or Zendium dentifrice. Acta Odontol Scand 1985; 43: 47–52. CrossRef MEDLINE
19.Gorsky M, Epstein J, Rabenstein S, Elishoov H, Yarom N: Topical minocycline and tetracycline rinses in treatment of recurrent aphthous stomatitis: a randomized cross-over study. Dermatol Online J 2007; 13: 1. MEDLINE
20.Altenburg A, Zouboulis CC: Current concepts in the treatment of recurrent aphthous stomatitis. Skin Therapy Lett 2008; 13(7): 1–4. MEDLINE
21.Zouboulis CC: Adamantiades-Behçet’s disease. In: Katsambas AD, Lotti TM, eds.: European Handbook of Dermatological Treatments. 2nd edition. Berlin: Springer 2003; 16–26. CrossRef
22.Fani MM, Ebrahimi H, Pourshahidi S, et al.: Comparing the effect of phenytoin syrup and triamcinolone acetonide ointment on aphthous ulcers in patients with Behçet´s syndrome. Iran Red Crescent Med J 2012; 14: 75–8. MEDLINE PubMed Central
23.Al-Na’mah ZM, Carson R, Thanoon IA: Dexamucobase: a novel treatment for oral aphthous ulceration. Quintessence Int 2009; 40: 399–404. MEDLINE
24.Vincent SD, Lilly GE: Clinical, historic, and therpeutic features of aphthous stomatitis. Literature review and open clinical trial employing steroids. Oral Surg Oral Med Oral Pathol 1992; 74: 79–86. CrossRef
25.Collier PM, Neill SM, Copeman PW: Topical 5-aminosalicylic acid: a treatment for aphthous ulcers. Br J Dermatol 1992; 126: 185–8. CrossRef MEDLINE
26.Greer RO Jr, Lindenmuth JE, Juarez T, Khandwala A: A double-blind study of topically applied 5 % amlexanox in the treatment of aphthous ulcers. J Oral Maxillofac Surg 1993; 51: 243–8. CrossRef
27.Liu J, Zeng X, Chen Q, et al.: An evaluation on the efficacy and safety of amlexanox oral adhesive tablets in the treatment of recurrent minor aphthous ulceration in a Chinese cohort: a randomized, double-blind, vehicle-controlled, unparallel multicenter clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; 102: 475–81. CrossRef MEDLINE
28.Marakoglu K, Sezer RE, Toker HC, Marakoglu I: The recurrent aphthous stomatitis frequency in the smoking cessation people. Clin Oral Investig 2007; 11: 149–53. CrossRef MEDLINE
29.Brocklehurst P, Tickle M, Glenny A-M, et al.: Systemic interventions for recurrent aphthous stomatitis (mouth ulcers). Cochrane Database of Systematic Reviews 2012; 9: CD005411. MEDLINE
30.Fontes V, Machet L, Huttenberger B, Lorette G, Vaillant L: Aphtose buccale récidivante: traitement par colchicine (Étude ouverte de 54 cas). Ann Dermatol Venereol 2002; 129: 1365–9. MEDLINE
31.Thornhill MH, Baccaglini L, Theaker E, Pemberton MN: A randomized, double-blind, placebo-controlled trial of pentoxifylline for the treatment of recurrent aphthous stomatitis. Arch Dermatol 2007; 143: 463–70. CrossRef MEDLINE
32.Pakfetrat A, Mansourian A, Momen-Heravi F, et al.: Comparison of colchicine versus prednisolone in recurrent aphthous stomatitis: A double-blind randomized clinical trial. Clin Invest Med 2010; 33: E189–95. MEDLINE
33.Femiano F, Buonaiuto C, Gombos F, Lanza A, Cirillo N: Pilot study on recurrent aphthous stomatitis (RAS): a randomized placebo-controlled trial for the comparative therapeutic effects of systemic prednisone and systemic montelukast in subjects unresponsive to topical therapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: 402–7. CrossRef MEDLINE
34.Alpsoy E, Er H, Durusoy C, Yilmaz E: The use of sucralfate suspension in the treatment of oral and genital ulceration of Behçet disease: a randomized, placebo-controlled, double-blind study. Arch Dermatol 1999; 135: 529–32. CrossRef MEDLINE
35.Yazici H, Pazarli H, Barnes CG, et al.: A controlled trial of azathioprine in Behçet’s syndrome. N Engl J Med 1990; 322: 281–5. CrossRef MEDLINE
36.Zouboulis CC: Morbus Adamantiades-Behçet. In: Mrowietz U, eds.: Ciclosporin in der Dermatologie. Stuttgart: Thieme 2003; 38–51.
37.Masuda K, Nakajima A, Urayama A, Nakae K, Kogure M, Inaba G: Double-masked trial of cyclosporine versus colchicine and long-term open study of cyclosporin in Behçet’s disease. Lancet 1989; 1: 1093–6. CrossRef MEDLINE
38.Zouboulis CC, Orfanos CE: Treatment of Adamantiades-Behçet’s disease with systemic interferon alfa. Arch Dermatol 1998; 134: 1010–6. CrossRef MEDLINE
39.Misra R, Anderson DC: Treatment of recurrent premenstrual orogenital aphthae with implants of low dose of testosterone. BMJ 1989; 299: 834. CrossRef MEDLINE PubMed Central
e1.Schroeder HE, Müller-Glauser W, Sallay K: Stereologic analysis of leukocyte infiltration in oral ulcers of developing Mikulicz aphthae. Oral Surg Oral Med Oral Pathol 1983; 56: 629–40. MEDLINE
e2.Altenburg A, Papoutsis N, Orawa H, Martus P, Krause L, Zouboulis CC: Epidemiologie und Klinik des Morbus Adamantiades-Behçet in Deutschland – Aktuelle pathogenetische Konzepte und therapeutische Möglichkeiten. J Dtsch Dermatol Ges 2006; 4: 49–64.
e3.Bruce AJ, Rogers RSW 3rd: Acute oral ulcers. Dermatol Clin 2003; 21: 49–61.
e4.Fox EC: The problem or oral ulcerations in general practice with special reference to herpetic herpetiform lesions. J R Coll Gen Pract 1970; 19: 191–200. MEDLINE
e5.Lopez-Jornet P, Camacho-Alonso F, Martos N: Hematological study of patients with aphthous stomatitis. Int J Dermatol 2014; 53: 159–63. MEDLINE
e6.Chen Y, Fang L, Yang X: Cyclic neutropenia presenting as recurrent oral ulcers and periodontitis. J Clin Pediatr Dent 2013; 37: 307–8. MEDLINE
e7.Koybasi S, Parlak AH, Serin E, Yilmaz F, Serin D: Recurrent aphthous stomatitis: investigation of possible etiologic factors. Am J Otolaryngol 2006; 27: 229–32. MEDLINE
e8.Volkov I, Rudoy I, Abu-Rabia U, Masalha T, Masalha R: Case report: Recurrent aphthous stomatitis responds to vitamin B12 treatment. Can Fam Physician 2005; 51: 844–5. MEDLINE PubMed Central
e9.Wray D, Graykowski EA, Notkins AL: Role of mucosal injury in initiating recurrent aphthous stomatitis. Br Med J (Clin Res Ed) 1981; 283: 1569–70. MEDLINE PubMed Central
e10.Jurge S, Kuffer R, Scully C, Porter SR: Mucosal disease series. Number VI. Recurrent aphthous stomatitis. Oral Dis 2006; 12: 1–21. CrossRef MEDLINE
e11.Jennette JC: 2012 revised International Chapel Hill Consensus Conference nomenclature of vasculitides. Arthritis Rheum 2013; 65: 1–11. MEDLINE
e12.International Study Group for Behçet’s Disease: Criteria for diagnosis of Behçet’s disease. Lancet 1990; 335: 1078–80. MEDLINE
e13.Gorsky M, Epstein J, Raviv A, Yaniv R, Truelove E: Topical minocycline for managing symptoms of recurrent aphthous stomatitis. Spec Care Dentist 2008; 28: 27–31. MEDLINE
e14.Rivera-Hidalgo F, Shulman JD, Beach MM: The association of tobacco and other factors with recurrent aphthous stomatitis in an US adult population. Oral Dis 2004; 10: 335–45. MEDLINE
e15.Bittoun R: Recurrent aphthous ulcers and nicotine. Med J Aust 1991; 154: 471–2. MEDLINE
e16.Davatchi F, Sadeghi Abdollahi B, et al.: Colchicine versus placebo in Behçet’s disease: randomized, double-blind, controlled crossover trial. Mod Rheumatol 2009; 19: 542–9. CrossRef MEDLINE
e17.Yurdakul S, Mat C, Tüzün Y, et al.: Double-blind trial of colchicine in Behçet’s syndrome. Arthritis Rheum 2001; 44: 2686–92. CrossRef MEDLINE
e18.Calgüneri M, Kiraz S, Ertenli I, Benekli M, Karaarslan Y, Celik I: The effect of prophylactic penicillin treatment on the course of arthritis episodes in patients with Behçet’s disease. A randomized clinical trial. Arthritis Rheum 1996; 39: 2062–5. MEDLINE
e19.Rattan J, Schneider M, Arber N, Gorsky M, Dayan D: Sucralfate suspension as a treatment of recurrent aphthous stomatitis.
J Intern Med 1994; 236: 341–3. MEDLINE
e20.Sharquie KE, Najim RA, Abu-Raghif AR: Dapsone in Behçet’s disease: a double-blind, placebo-controlled, cross-over study. J Dermatol 2002; 29: 267–79. MEDLINE
e21.Bonnetblanc JM, Royer C, Bedane C: Thalidomide and recurrent aphthous stomatitis: A follow-up study. Dermatology 1996; 193: 321–3. MEDLINE
e22.Grinspan D: Significant response of oral aphthosis to thalidomide treatment. J Am Acad Dermatol 1985; 12: 85–90. MEDLINE
e23.Grinspan D, Blanco GF, Aguero S: Treatment of aphthae with thalidomide. J Am Acad Dermatol 1989; 20: 1060–3. MEDLINE
e24.Hamuryudan V, Mat C, Saip S, et al.: Thalidomide in the treatment of the mucocutaneous lesions of the Behçet syndrome. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 1998; 128: 443–50. CrossRef MEDLINE
e25.Calabrese L, Fleischer AB: Thalidomide: current and potential clinical applications. Am J Med 2000; 108: 487–95. MEDLINE
e26.Alpsoy E, Durusoy C, Yilmaz E, et al.: Interferon alfa-2a in the treatment of Behçet disease: a randomized placebo-controlled and double-blind study. Arch Dermatol 2002; 138: 467–71. CrossRef MEDLINE
e27.Demiroglu H, Ozcebe OI, Barista I, Dündar S, Eldem B: Interferon alfa-2b, colchicine, and benzathine penicillin versus colchicine and benzathine penicillin in Behçet’s disease: a randomised trial. Lancet 2000; 355: 605–9. MEDLINE
e28.Preshaw PM, Grainger P, Bradshaw MH, Mohammad AR, Powala CV, Nolan A: Subantimicrobial dose doxycycline in the treatment of recurrent oral aphthous ulceration: a pilot study. J Oral Pathol Med 2007; 36: 236–40. MEDLINE
e29.Sharquie KE, Najim RA, Al-Hayani RK, Al-Nuaimy AA, Maroof DM: The therapeutic and prophylactic role of oral zinc sulfate in management of recurrent aphthous stomatitis (ras) in comparison with dapsone. Saudi Med J 2008; 29: 734–8. MEDLINE
e30.Murray B, Biagioni PA, Lamey PJ: The efficacy of amlexanox OraDisc on the prevention of recurrent minor aphthous ulceration. J Oral Pathol Med 2006; 35: 117–22. MEDLINE
e31.Pourahmad M, Rahiminejad M, Fadaei S, Kashafi H: Effects of camel thorn distillate on recurrent oral aphthous lesions. J Dtsch Dermatol Ges 2010; 8: 348–52. MEDLINE
e32.Matsuda T, Ohno S, Hirohata S, et al.: Efficacy of rebamipide as adjunctive therapy in the treatment of recurrent oral aphthous ulcers in patients with Behçet’s disease: a randomised, double-blind, placebo-controlled study. Drugs 2003; 4: 19–28. MEDLINE
e33.Melikoglu M, Fresko I, Mat C, et al.: Short-term trial of etanercept in Behçet’s disease: a double blind, placebo controlled study. J Rheumatol 2005; 32: 98–105. MEDLINE
e34.de Abreu MA, Hirata CH, Pimentel DR, Weckx LL: Treatment of recurrent aphthous stomatitis with clofazimine. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 108: 714–21. MEDLINE