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Urosepsis—Etiology, Diagnosis, and Treatment

Dtsch Arztebl Int 2015; 112: 837-48. DOI: 10.3238/arztebl.2015.0837

Dreger, N M; Degener, S; Ahmad-Nejad, P; Wöbker, G; Roth, S

1.Rivers E, Nguyen B, Havstad S, et al.: Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345: 1368–77 CrossRef MEDLINE
2.Reinhart K, Brunkhorst FM, Bone HG, et al.: Prevention, diagnosis, therapy and follow-up care of sepsis: 1st revision of S-2k guidelines of the German Sepsis Society (Deutsche Sepsis-Gesellschaft e. V. (DSG)) and the German Interdisciplinary Association of Intensive Care and Emergency Medicine (Deutsche Interdisziplinare Vereinigung fur Intensiv- und Notfallmedizin (DIVI)). Ger Med Sci 2010; 8: Doc14 MEDLINE PubMed Central
3.Levy MM, Artigas A, Phillips GS, et al.: Outcomes of the surviving sepsis campaign in intensive care units in the USA and Europe: a prospective cohort study. Lancet Infect Dis 2012; 12: 919–24 CrossRef
4.Dellinger RP, Levy MM, Rhodes A, et al.: Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 2013; 39: 165–228 CrossRef MEDLINE
5.Grabe M, Bartoletti R, Bjerklund Johansen TE, et al.: Urological infections. European Association of Urology Guidelines: Elsevier 2015: 641–6.
6.Bone RC, Balk RA, Cerra FB, et al.: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101: 1644–55 CrossRef MEDLINE
7.Levy MM, Fink MP, Marshall JC, et al.: 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003; 31: 1250–6 CrossRef MEDLINE
8.Engel C, Brunkhorst FM, Bone HG, et al.: Epidemiology of sepsis in Germany: results from a national prospective multicenter study. Intensive Care Med 2007; 33: 606–18 CrossRef MEDLINE
9.Martin GS, Mannino DM, Eaton S, Moss M: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003; 348: 1546–54 CrossRef MEDLINE
10.Wagenlehner FM, Lichtenstern C, Rolfes C, et al.: Diagnosis and management for urosepsis. Int J Urol 2013; 20: 963–70 CrossRef
11.Brun-Buisson C, Meshaka P, Pinton P, Vallet B, Group ES: EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units. Intensive Care Med 2004; 30: 580–8 CrossRef MEDLINE
12.Brunkhorst FM: [Epidemiology, economy and practice–results of the German study on prevalence by the competence network sepsis (SepNet)]. Anasthesiol Intensivmed Notfallmed Schmerzther 2006; 41: 43–4 CrossRef MEDLINE
13.Moerer O, Schmid A, Hofmann M, et al.: Direct costs of severe sepsis in three German intensive care units based on retrospective electronic patient record analysis of resource use. Intensive Care Med 2002; 28: 1440–6 CrossRef MEDLINE
14.Hotchkiss RS, Karl IE: The pathophysiology and treatment of sepsis. N Engl J Med 2003; 348: 138–50 CrossRef MEDLINE
15.Astiz ME, Rackow EC: Septic shock. Lancet 1998; 351: 1501–5 CrossRef
16.Mariappan P, Loong CW: Midstream urine culture and sensitivity test is a poor predictor of infected urine proximal to the obstructing ureteral stone or infected stones: a prospective clinical study. J Urol 2004; 171: 2142–5 CrossRef
17.Luzzani A, Polati E, Dorizzi R, Rungatscher A, Pavan R, Merlini A: Comparison of procalcitonin and C-reactive protein as markers of sepsis. Crit Care Med 2003; 31: 1737–41 CrossRef MEDLINE
18.Simon L, Gauvin F, Amre DK, Saint-Louis P, Lacroix J: Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. Clin Infect Dis 2004; 39: 206–17 CrossRef MEDLINE
19.Brunkhorst FM, Wegscheider K, Forycki ZF, Brunkhorst R: Procalcitonin for early diagnosis and differentiation of SIRS, sepsis, severe sepsis, and septic shock. Intensive Care Med 2000; 26 (Suppl 2): 148–52 CrossRef CrossRef MEDLINE
20.van Nieuwkoop C, Bonten TN, van't Wout JW, et al.: Procalcitonin reflects bacteremia and bacterial load in urosepsis syndrome: a prospective observational study. Crit Care 2010; 14: R206 CrossRef MEDLINE PubMed Central
21.Schuetz P, Christ-Crain M, Thomann R, et al.: Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial. JAMA 2009; 302: 1059–66 CrossRef MEDLINE
22.Nobre V, Harbarth S, Graf JD, Rohner P, Pugin J: Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trial. Am J Respir Crit Care Med 2008; 177: 498–505 CrossRef MEDLINE
23.Heyland DK, Johnson AP, Reynolds SC, Muscedere J: Procalcitonin for reduced antibiotic exposure in the critical care setting: a systematic review and an economic evaluation. Crit Care Med 2011; 39: 1792–9 CrossRef MEDLINE
24.Kumar A, Ellis P, Arabi Y, et al.: Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest 2009; 136: 1237–48 MEDLINE
25.Kumar A, Roberts D, Wood KE, et al.: Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006; 34: 1589–96 CrossRef MEDLINE
26.Mouncey PR, Osborn TM, Power GS, et al.: Trial of early, goal-directed resuscitation for septic shock. N Engl J Med 2015; 372: 1301–11 CrossRef MEDLINE
27.Pro CI, Yealy DM, Kellum JA, et al.: A randomized trial of protocol-based care for early septic shock. N Engl J Med 2014; 370: 1683–93 CrossRef MEDLINE PubMed Central
28.Investigators A, Group ACT, Peake SL, et al.: Goal-directed resuscitation for patients with early septic shock. N Engl J Med 2014; 371: 1496–506 CrossRef MEDLINE
29.Ramsey S, Robertson A, Ablett MJ, Meddings RN, Hollins GW, Little B: Evidence-based drainage of infected hydronephrosis secondary to ureteric calculi. J Endourol 2010; 24: 185–9 CrossRef MEDLINE
30.Brunkhorst FM, Engel C, Bloos F, et al.: Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008; 358: 125–39 CrossRef MEDLINE
31.Guidet B, Martinet O, Boulain T, et al.: Assessment of hemodynamic efficacy and safety of 6% hydroxyethylstarch 130/0.4 vs. 0.9% NaCl fluid replacement in patients with severe sepsis: the CRYSTMAS study. Crit Care 2012; 16: R94 CrossRef MEDLINE PubMed Central
32.Myburgh JA, Finfer S, Bellomo R, et al.: Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med 2012; 367: 1901–11 CrossRef MEDLINE
33.Perner A, Haase N, Guttormsen AB, et al.: Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis. N Engl J Med 2012; 367: 124–34 CrossRef MEDLINE
34.Martin C, Viviand X, Leone M, Thirion X: Effect of norepinephrine on the outcome of septic shock. Crit Care Med 2000; 28: 2758–65 CrossRef
35.Bellomo R, Chapman M, Finfer S, Hickling K, Myburgh J: Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Lancet 2000; 356: 2139–43 CrossRef
36.Sprung CL, Annane D, Keh D, et al.: Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008; 358: 111–24 CrossRef MEDLINE
37. Investigators N-SS, Finfer S, Chittock DR, et al.: Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009; 360: 1283–97 CrossRef MEDLINE
38.Martin GS, Mannino DM, Moss M: The effect of age on the development and outcome of adult sepsis. Crit Care Med 2006; 34: 15–21 CrossRef
39.Bjerklund Johansen TE, Cek M, Naber K, et al.: Prevalence of hospital-acquired urinary tract infections in urology departments. Eur Urol 2007; 51: 1100–11; discussion 12 CrossRef MEDLINE
40.Wagenlehner FM, Umeh O, Steenbergen J, Yuan G, Darouiche RO: Ceftolozane-tazobactam compared with levofloxacin in the treatment of complicated urinary-tract infections, including pyelonephritis: a randomised, double-blind, phase 3 trial (ASPECT-cUTI). Lancet 2015; 385: 1949–56 CrossRef
e1.Moerer O, Quintel M: [Sepsis in adult patients – definitions, epidemiology and economic aspects]. Der Internist 2009; 50: 788, 90–4, 96–8.
e2.Mehta RL, Kellum JA, Shah SV, et al.: Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007; 11: R31.
e3.Angus DC: The lingering consequences of sepsis: a hidden public health disaster? JAMA 2010; 304: 1833–4 CrossRef
e4.Moerer O, Burchardi H: [The cost of sepsis]. Anaesthesist 2006; 55 (Suppl 1): 36–42.
e5.Schmid A, Burchardi H, Clouth J, Schneider H: Burden of illness imposed by severe sepsis in Germany. Eur J Health Econ: HEPAC : health economics in prevention and care 2002; 3: 77–82 CrossRef
e6. Schiefer HG: Urosepsis. In: Schmelz H, Sparwasser C, Weidner W, (eds.): Facharztwissen Urologie. Heidelberg: SpringerMedizin 2014; 51–7.
e7.Hofmann W: [Urosepsis and uroseptic shock]. Z Urol Nephrol 1990; 83: 317–24.
e8.Serniak PS, Denisov VK, Guba GB, et al.: [The diagnosis of urosepsis]. Urol Nefrol (Mosk) 1990: 9–13.
e9.Stehr SN, Woest I, Hartog CS, Reinhart K: [Sepsis: putting knowledge into practice]. Der Internist 2013; 54: 63–72; quiz 3–4.
e10.Rittirsch D, Flierl MA, Ward PA: Harmful molecular mechanisms in sepsis. Nat Rev Immunol 2008; 8: 776–87 CrossRef
e11.Hacker H, Vabulas RM, Takeuchi O, Hoshino K, Akira S, Wagner H: Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J Exp Med 2000; 192: 595–600 CrossRef
e12.Medzhitov R, Preston-Hurlburt P, Kopp E, et al.: MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell 1998; 2: 253–8 CrossRef
e13.Wesche H, Henzel WJ, Shillinglaw W, Li S, Cao Z: MyD88: an adapter that recruits IRAK to the IL-1 receptor complex. Immunity 1997; 7: 837–47 CrossRef
e14.Takeuchi O, Hoshino K, Kawai T, et al.: Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 1999; 11: 443–51 CrossRef
e15.Wagenlehner FM, Lichtenstern C, Weigand MA, Weidner W: [Urosepsis and treatment]. Urologe A 2010; 49: 618–22.
e16.Chen YX, Li CS: Risk stratification and prognostic performance of the predisposition, infection, response, and organ dysfunction (PIRO) scoring system in septic patients in the emergency department: a cohort study. Crit Care 2014; 18: R74 CrossRef
e17.Reimer LG, Wilson ML, Weinstein MP: Update on detection of bacteremia and fungemia. Clin Microbiol Rev 1997; 10: 444–65.
e18.Cockerill FR, 3rd, Wilson JW, Vetter EA, et al.: Optimal testing parameters for blood cultures. Clin Infect Dis 2004; 38: 1724–30 CrossRef
e19.Bele N, Darmon M, Coquet I, et al.: Diagnostic accuracy of procalcitonin in critically ill immunocompromised patients. BMC Infect Dis 2011; 11: 224 CrossRef
e20.Otto G, Braconier J, Andreasson A, Svanborg C: Interleukin-6 and disease severity in patients with bacteremic and nonbacteremic febrile urinary tract infection. J Infect Dis 1999; 179: 172–9 CrossRef
e21.Lvovschi V, Arnaud L, Parizot C, et al.: Cytokine profiles in sepsis have limited relevance for stratifying patients in the emergency department: a prospective observational study. PLoS One 2011; 6: e28870.
e22.Vincent JL, Beumier M: Diagnostic and prognostic markers in sepsis. Expert Rev Anti Infect Ther 2013; 11: 265–75 CrossRef MEDLINE
e23.Llewelyn M, Cohen J, International Sepsis F: Diagnosis of infection in sepsis. Intensive Care Med 2001; 27 (Suppl 1): S10–32 CrossRefMEDLINE
e24.Brandt AS, Degener S, Lazica DA, Roth S: [Diagnostic puncture of the renal pelvis: avoidance of urinary diversion in cases of hydronephrosis and non-specific fever]. Urologe A 2012; 51: 1438–43 MEDLINE
e25.Hoddick W, Jeffrey RB, Goldberg HI, Federle MP, Laing FC: CT and sonography of severe renal and perirenal infections. AJR Am J Roentgenol 1983; 140: 517–20 CrossRef MEDLINE
e26.Wagenlehner FM, Pilatz A, Weidner W: Urosepsis--from the view of the urologist. Int J Antimicrob Agents 2011; 38 (Suppl): 51–7 CrossRef MEDLINE
e27.Auinger K, Maggiorini M: Early, goal-directed resuscitation for septic shock. N Engl J Med 2015; 373: 576 CrossRef MEDLINE
e28.Roberts JA, Lipman J: Antibacterial dosing in intensive care: pharmacokinetics, degree of disease and pharmacodynamics of sepsis. Clin Pharmacokinet 2006; 45: 755–73 MEDLINE
e29.Brunkhorst FM, Oppert M, Marx G, et al.: Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial. JAMA 2012; 307: 2390–9 CrossRef MEDLINE
e30.Lorente JA, Landin L, De Pablo R, Renes E, Rodriguez-Diaz R, Liste D: Effects of blood transfusion on oxygen transport variables in severe sepsis. Crit Care Med 1993; 21: 1312–8 CrossRef
e31.Annane D, Sebille V, Charpentier C, et al.: Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002; 288: 862–71 CrossRef MEDLINE
e32.Briegel J, Forst H, Haller M, et al.: Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomized, double-blind, single-center study. Crit Care Med 1999; 27: 723–32 CrossRef MEDLINE
e33.Bollaert PE, Charpentier C, Levy B, Debouverie M, Audibert G, Larcan A: Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Crit Care Med 1998; 26: 645–50 CrossRef
e34.Beale R, Janes JM, Brunkhorst FM, et al.: Global utilization of low-dose corticosteroids in severe sepsis and septic shock: a report from the PROGRESS registry. Crit Care 2010; 14: R102.
e35.Heyland DK: Selenium supplementation in critically ill patients: can too much of a good thing be a bad thing? Crit Care 2007; 11: 153 CrossRef MEDLINE PubMed Central
e36.Ranieri VM, Thompson BT, Barie PS, et al.: Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med 2012; 366: 2055–64 CrossRef MEDLINE
e37.Hetz H, Berger R, Recknagel P, Steltzer H: Septic shock secondary to beta-hemolytic streptococcus-induced necrotizing fasciitis treated with a novel cytokine adsorption therapy. Int J Artif Organs 2014; 37: 422–6 CrossRef MEDLINE
e38.Wiegele M, Krenn CG: Cytosorb in a patient with legionella pneumonia-associated rhabdomyolysis: a case report. ASAIO J 2015; 61: e14–6 CrossRef MEDLINE
e39.Puskarich MA, Trzeciak S, Shapiro NI, et al.: Outcomes of patients undergoing early sepsis resuscitation for cryptic shock compared with overt shock. Resuscitation 2011; 82: 1289–93 CrossRef MEDLINE PubMed Central
e40.Johansen TE, Cek M, Naber KG, et al.: Hospital acquired urinary tract infections in urology departments: pathogens, susceptibility and use of antibiotics. Data from the PEP and PEAP-studies. Int J Antimicrob Agents 2006; 28 (Suppl 1): S91–107.
e41.Bouza E, San Juan R, Munoz P, Voss A, Kluytmans J, Co-operative Group of the European Study Group on Nosocomial infection: A European perspective on nosocomial urinary tract infections II. Report on incidence, clinical characteristics and outcome (ESGNI-004 study). European Study Group on Nosocomial Infection. Clin Microbiol Infect 2001; 7: 532–42 CrossRef MEDLINE < /td>
e42. Alhambra A, Cuadros JA, Cacho J, Gomez-Garces JL, Alos JI: In vitro susceptibility of recent antibiotic-resistant urinary pathogens to ertapenem and 12 other antibiotics. J Antimicrob Chemother 2004; 53: 1090–4 CrossRef MEDLINE
e43.Reinhart K, Bauer M, Riedemann NC, Hartog CS: New approaches to sepsis: molecular diagnostics and biomarkers. Clin Microbiol Rev 2012; 25: 609–34 CrossRef MEDLINE PubMed Central