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The Presentation, Diagnosis, and Treatment of Sexually Transmitted Infections

Dtsch Arztebl Int 2016; 113: 11-22. DOI: 10.3238/arztebl.2016.0011

Wagenlehner, F M; Brockmeyer, N H; Discher, T; Friese, K; Wichelhaus, T A

1. WHO: Sexually transmitted infections (STIs) 2013. Fact Sheet N. 110. www.who.int/mediacentre/factsheets/fs110/en/ (last accessed on 10 November 2015).
2.Robert Koch-Institut: Sechs Jahre STD-Sentinel Surveillance in Deutschland – Zahlen und Fakten. Epidemiologisches Bulletin 2010; 3: 20–27.
3. Hokororo A, Kihunrwa A, Hoekstra P, et al.: High prevalence of sexually transmitted infections in pregnant adolescent girls in Tanzania: a multi-community cross-sectional study. Sex Transm Infect 2015; 91: 473–8 CrossRef MEDLINE
4.Kissinger P: Trichomonas vaginalis: a review of epidemiologic, clinical and treatment issues. BMC Infect Dis 2015; 15: 307 CrossRef MEDLINE PubMed Central
5. Bremer V, Brockmeyer N, Coenenberg J, et al.: Leitlinie STI/STD– Beratung, Diagnostik und Therapie. In: AWMF, 2014. www.awmf.org/uploads/tx_szleitlinien/059–006l_S1_STI_STD-Beratung_2015–07.pdf (last accessed on 10 December 2015).
6. Workowski KA, Bolan G: Sexually transmitted diseases treatment guidelines, 2014. In: Control CfD, editor.; 2014.
7. Bremer V, Brockmeyer NH, Esser S, et al.: Leitlinie Diagnostik und Therapie der Syphilis, Aktualisierung und Aufwertung S2k2014. In: AWMF; 2014. www.awmf.org/uploads/tx_szleitlinien/059–002l_S2k_Diagnostik_Therapie_Syphilis_2014_07.pdf (last accessed on 10 December 2015).
8.Beckmann M, Wojcinski M, Weissenbacher ER, et al: Leitlinie Prävention, Diagnostik und Therapie der HPV-Infektion und präinvasiver Läsionen des weiblichen Genitale. In: AWMF; 2010. www.awmf.org/uploads/tx_szleitlinien/015–027_S2_IDA_Praevention_Diagnostik_und_Therapie_der_HPV-Infektion_und_praeinvasiver_Laesionen_des_weiblichen_Genitale_abgelaufen.pdf (last accessed on 10 December 2015).
9. Bremer V, Brockmeyer N, Buder, S, et al.: Gonorrhoe bei Erwachsenen und Adoleszenten. In: AWMF, 2013. www.awmf.org/uploads/tx_szleitlinien/059–004l_S25_Gonorrhoe_bei_Erwachsenen_Adoleszenten_2014-verlaengert.pdf (last accessed on 10 December 2015).
10. Abele-Horn M, Blenk H, Clad A, et al.: Genitalinfektionen Teil I: Infektionen des weiblichen und des männlichen Genitaltraktes. München: Urban & Fischer 2011.
11. Abele-Horn M, Blenk H, Clad A,et al: Genitalinfektionen Teil II. Infektionserreger: Bakterien. München: Urban & Fischer; 2011.
12. Abele-Horn M, Blenk H, Clad A, et al.: Genitalinfektionen Teil II. Infektionserreger: Parasiten, Viren. München: Urban & Fischer; 2011.
13. Le Cleach L, Trinquart L, Do G, et al.: Oral antiviral therapy for prevention of genital herpes outbreaks in immunocompetent and nonpregnant patients. Cochrane Database Syst Rev 2014; 8: CD009036 CrossRef
14. Williams JR, Jordan JC, Davis EA, Garnett GP: Suppressive valacyclovir therapy: impact on the population spread of HSV-2 infection. Sex Transm Dis 2007; 34: 123–31 CrossRef MEDLINE
15. Bartelsman M, Straetemans M, Vaughan K, et al.: Comparison of two Gram stain point-of-care systems for urogenital gonorrhoea among high-risk patients: diagnostic accuracy and cost-effectiveness before and after changing the screening algorithm at an STI clinic in Amsterdam. Sex Transm Infect 2014; 90: 358–62 CrossRef MEDLINE
16. Lewis DA: Global resistance of Neisseria gonorrhoeae: when theory becomes reality. Curr Opin Infect Dis 2014; 27: 62–7 CrossRef MEDLINE
17. Ndowa F, Lusti-Narasimhan M, Unemo M: The serious threat of multidrug-resistant and untreatable gonorrhoea: the pressing need for global action to control the spread of antimicrobial resistance, and mitigate the impact on sexual and reproductive health. Sex Transm Infect 2012; 88: 317–8 CrossRef MEDLINE
18. Unemo M, Nicholas RA: Emergence of multidrug-resistant, extensively drug-resistant and untreatable gonorrhea. Future Microbiol 2012; 7: 1401–22 CrossRef MEDLINE PubMed Central
19. Horn NN, Kresken M, Korber-Irrgang B, et al. Antimicrobial susceptibility and molecular epidemiology of Neisseria gonorrhoeae in Germany. Int J Med Microbiol 2014; 304: 586–91 CrossRef MEDLINE
20. Horner P, Blee K, Adams E: Time to manage mycoplasma genitalium as an STI: but not with azithromycin 1 g! Curr Opin Infect Dis 2014; 27: 68–74 CrossRef MEDLINE
21. Cook RL, Hutchison SL, Ostergaard L, Braithwaite RS, Ness RB: Systematic review: noninvasive testing for Chlamydia trachomatis and Neisseria gonorrhoeae. Ann Intern Med 2005; 142: 914–25 CrossRef
22.Yanofsky VR, Patel RV, Goldenberg G: Genital warts: a comprehensive review. J Clin Aesthet Dermatol 2012; 5: 25–36 MEDLINEPubMed Central
23.Roth AM, Williams JA, Ly R, et al.: Changing sexually transmitted infection screening protocol will result in improved case finding for trichomonas vaginalis among high-risk female populations. Sex Transm Dis 2011; 38: 398–400 CrossRef MEDLINE
24. Kreuter A, Brockmeyer NH, Hochdorfer B, et al.: Clinical spectrum and virologic characteristics of anal intraepithelial neoplasia in HIV infection. J Am Acad Dermatol 2005; 52: 603–8 CrossRef MEDLINE
25.Robert Koch-Institut: HIV-Diagnosen und AIDS-Erkrankungen in Deutschland. Epidemiologisches Bulletin 2015; 27.
26.Lohse N, Hansen AB, Pedersen G, et al.: Survival of persons with and without HIV infection in Denmark, 1995–2005. Ann Intern Med 2007; 146: 87–95 CrossRef MEDLINE
27.May M, Gompels M, Delpech V, et al.: Impact of late diagnosis and treatment on life expectancy in people with HIV-1:
UK Collaborative HIV Cohort (UK CHIC) Study. BMJ 2011; 343: d6016 CrossRef MEDLINE PubMed Central
28.Sabin CA: Do people with HIV infection have a normal life expectancy in the era of combination antiretroviral therapy? BMC Med 2013; 11: 251 CrossRef MEDLINE PubMed Central
29. Smith CJ, Ryom L, Weber R, et al.: Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D): a multicohort collaboration. Lancet 2014; 384: 241–8 CrossRef
30. Weber R, Ruppik M, Rickenbach M, et al.: Decreasing mortality and changing patterns of causes of death in the Swiss HIV Cohort Study. HIV Med 2013; 14: 195–207 CrossRefMEDLINE
31. Bernstein KT, Marcus JL, Nieri G, Philip SS, Klausner JD: Rectal gonorrhea and chlamydia reinfection is associated with increased risk of HIV seroconversion. J Acquir Immune Defic Syndr 2010; 53: 537–43 CrossRef MEDLINE
32. Pathela P, Braunstein SL, Blank S, Schillinger JA: HIV incidence among men with and those without sexually transmitted rectal infections: estimates from matching against an HIV case registry. Clin Infect Dis 2013; 57: 1203–9 CrossRef MEDLINE
33. Patel P, Bush T, Mayer K, et al.: Routine brief risk-reduction counseling with biannual STD testing reduces STD incidence among HIV-infected men who have sex with men in care. Sex Transm Dis 2012; 39: 470–4 CrossRef MEDLINE
34.Robert Koch-Institut: Syphilis in Deutschland 2012. Epidemiologisches Bulletin 2013; 44.
35.WHO: Guideline on when to start antiretroviral therapy and on pre-exposure prophylaxis for HIV. 2015. apps.who.int/iris/bitstream/10665/186275/1/9789241509565_eng.pdf?ua=1 (last accessed on 10 December 2015).
36. Cohen MS, Chen YQ, McCauley M, et al.: Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med 2011; 365: 493–505 CrossRef MEDLINE PubMed Central
37. van de Laar TJ, Matthews GV, Prins M, Danta M: Acute hepatitis C in HIV-infected men who have sex with men: an emerging sexually transmitted infection. AIDS 2010; 24: 1799–812 CrossRef MEDLINE
38. Cornberg M, Manns MP: New kids on the block—step by step to an ideal HCV therapy. Lancet 2015; 385: 1050–2 CrossRef
e1. Kent CK, Chaw JK, Wong W, et al.: Prevalence of rectal, urethral, and pharyngeal chlamydia and gonorrhea detected in 2 clinical settings among men who have sex with men: San Francisco, California, 2003. Clin Infect Dis 2005; 41: 67–74 CrossRef MEDLINE
e2.Keikawus A, Baumgarten A, Behrens G, et al.: Deutsch-Österreichische Leitlinien zur antiretroviralen Therapie der HIV-Infektion. In: AWMF, 2014. www.awmf.org/uploads/tx_szleitlinien/055–001l_Antiretrovirale_Therapie_der_HIV_Infektion__2014–05.pdf (last accessed on 10 December 2015).
e3. Aberg JA, Gallant JE, Ghanem KG, et al.: Primary care guidelines for the management of persons infected with HIV: 2013 update by the HIV medicine association of the infectious diseases Society of America. Clin Infect Dis 2014; 58: e1–34.
e4.Workowski K, Berman, S, et al.: Sexually transmitted diseases treatment guidelines 2010. In: Centers for Disease Control and Prevention. MMWR 2010; 59: 1–110.
e5.Serwadda D, Gray RH, Sewankambo NK, et al.: Human immunodeficiency virus acquisition associated with genital ulcer disease and herpes simplex virus type 2 infection: a nested case-control study in Rakai, Uganda. J Infect Dis 2003; 188: 1492–7 CrossRef MEDLINE
e6.Freeman EE, Weiss HA, Glynn JR, Cross PL, Whitworth JA, Hayes RJ: Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies. AIDS 2006; 20: 73–83 CrossRef
e7.Janata O, Reisinger E: Infektiologie. Aktuelle Aspekte 2001/2002. Wien: Springer Verlag 2001.
e8.Deutsche STI-Gesellschaft: STI-Leitfaden 2014. www.dstig.de/literaturleitlinienlinks/sti-leitfaden.html (last accessed on 10
December 2015).
e9.Li DK, Raebel MA, Cheetham TC, et al.: Genital herpes and its treatment in relation to preterm delivery. Am J Epidemiol 2014; 180: 1109–17 CrossRef MEDLINE
e10.Bradshaw CS, Tabrizi SN, Read TR, et al.: Etiologies of nongonococcal urethritis: bacteria, viruses, and the association with orogenital exposure. J Infect Dis 2006; 193: 336–45 CrossRef MEDLINE
e11.Anagrius C, Lore B, Jensen JS: Treatment of mycoplasma genitalium. Observations from a Swedish STD clinic. PLoS One 2013; 8: e61481 CrossRef MEDLINE PubMed Central
e12.Marrazzo JM, Handsfield HH, Whittington WL: Predicting chlamydial and gonococcal cervical infection: implications for management of cervicitis. Obstet Gynecol 2002; 100: 579–84 CrossRef
e13.Moodley D, Moodley P, Sebitloane M, et al.: High prevalence and incidence of asymptomatic sexually transmitted infections during pregnancy and postdelivery in KwaZulu Natal, South Africa. Sex Transm Dis 2015; 42: 43–7 CrossRef MEDLINE
e14.Kissinger P, Adamski A: Trichomoniasis and HIV interactions:
a review. Sex Transm Infect 2013; 89: 426–33 CrossRef MEDLINE PubMed Central
e15.Schwebke JR, Hobbs MM, Taylor SN, et al.: Molecular testing for trichomonas vaginalis in women: results from a prospective U.S. clinical trial. J Clin Microbiol 2011; 49: 4106–11 CrossRef MEDLINE PubMed Central
e16.Ramqvist T, Grun N, Dalianis T: Human papillomavirus and tonsillar and base of tongue cancer. Viruses 2015; 7: 1332–43 CrossRef MEDLINEPubMed Central
e17.Nielson CM, Harris RB, Dunne EF, et al.: Risk factors for anogenital human papillomavirus infection in men. J Infect Dis 2007; 196: 1137–45 CrossRef MEDLINE PubMed Central
e18.Brockmeyer N, Degen O, Eldering G, et al.: Anale Dysplasien und Analkarzinome bei HIV-Infizierten: Prävention, Diagnostik, Therapie. In: AWMF; 2014.
e19.Samji H, Cescon A, Hogg RS, et al.: Closing the gap: increases in life expectancy among treated HIV-positive individuals in the United States and Canada. PLoS One 2013; 8: e81355.
e20.Hollingsworth TD, Anderson RM, Fraser C: HIV-1 transmission, by stage of infection. J Infect Dis 2008; 198: 687–93 CrossRef MEDLINE
e21.Fiebig EW, Wright DJ, Rawal BD, et al.: Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection. AIDS 2003; 17: 1871–9 CrossRef MEDLINE
e22.Vernazza P, Hirschel, B, Bernasconi, E, Flepp, M: HIV-infizierte Menschen ohne andere STD sind unter wirksamer antiretroviraler Therapie sexuell nich infektiös. Schweizerische Ärztezeitung 2008; 89: 165–169.
e23.Patel P, Borkowf CB, Brooks JT, Lasry A, Lansky A, Mermin J: Estimating per-act HIV transmission risk: a systematic review. AIDS 2014; 28: 1509–19 CrossRef MEDLINE
e24.Rodger A, Bruun T, Weait M, et al.: HIV-transmission risk through condomless sex if the HIV positive partner on suppressiv ART: PARTNER Study. In: CROI. Boston; 2014.
e25.Department of Health and Human Services: Panel on antiretroviral guidelines for adults and adolescents. Guidelines for the use of an-tiretroviral agents in HIV-1-infected adults and adolescents. www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf. (last accessed on 10 December 2015)
e26.Urbanus AT, van de Laar TJ, Stolte IG, et al.: Hepatitis C virus infections among HIV-infected men who have sex with men: an expanding epidemic. AIDS 2009; 23: F1–7.
e27.European Association for Study of Liver: EASL Clinical Practice Guidelines: management of hepatitis C virus infection. J Hepatol 2014; 60: 392–420 CrossRef MEDLINE
e28.Sarrazin C, Berg T, Buggisch P, et al.: Aktuelle Empfehlung zur Therapie der chronischen Hepatitis C Addendum vom 18. 2. 2015 zur S3-Leitlinie 021/012. www.awmf.org/fileadmin/user_upload/Leitlinien/021_D_Ges_fuer_Verdauungs-_und_Stoffwechselkrankheiten/021–012a_S3_Hepatitis-C-Addendum_2015–02.pdf (Last accessed on 10 December 2015).
e29. Wedemeyer H. [Treatment of hepatitis C: what is known?]. Internist 2014; 55: 1419–26 CrossRef MEDLINE