DÄ internationalArchiveReferences
References

cme

The Neurophysiology and Treatment of Motion Sickness

Dtsch Arztebl Int 2018; 115: 687-96. DOI: 10.3238/arztebl.2018.0687

Koch, A; Cascorbi, I; Westhofen, M; Dafotakis, M; Klapa, S; Kuhtz-Buschbeck, J P

1.Jelinek T: Kursbuch Reisemedizin: Beratung, Prophylaxe, Reisen mit Erkrankungen. Stuttgart, New York: Georg Thieme Verlag 2012; 68–71.
2.Krueger WWO: Controlling motion sickness and spatial disorientation and enhancing vestibular rehabilitation with a user-worn see-through display. Laryngoscope 2011; 121(Suppl. 2): 17–35 CrossRef MEDLINE PubMed Central
3. Diels C, Bos JE: Self-driving carsickness. Appl Ergon 2016; 53 Pt B: 374–82.
4. Riola JM, Pérez R: The seasickness phenomenom. J Marit Res 2012; 9: 67–72.
5. Regan EC, Price KR: The frequency of occurrence and severity of side-effects of immersion virtual reality. Aviat Space Environ Med 1994; 65: 527–30 MEDLINE
6.Paillard AC, Quarck G, Paolino F, et al.: Motion sickness susceptibility in healthy subjects and vestibular patients: effects of gender, age and trait-anxiety. J Vestib Res Equilib Orientat 2013; 23: 203–9.
7. Klosterhalfen S, Kellermann S, Pan F, Stockhorst U, Hall G, Enck P: Effects of ethnicity and gender on motion sickness susceptibility. Aviat Space Environ Med 2005; 76: 1051–7 MEDLINE
8. Bos JE, Damala D, Lewis C, Ganguly A, Turan O: Susceptibility to seasickness. Ergonomics 2007; 50: 890–901 CrossRef MEDLINE
9.Zhou W, Wang J, Pan L, et al.: Sex and age differences in motion sickness in rats: The correlation with blood hormone responses and neuronal activation in the vestibular and autonomic nuclei. Front Aging Neurosci 2017; 9: 29 CrossRef MEDLINE PubMed Central
10. Reavley CM, Golding JF, Cherkas LF, Spector TD, MacGregor AJ: Genetic influences on motion sickness susceptibility in adult women: a classical twin study. Aviat Space Environ Med 2006; 77: 1148–52 MEDLINE
11. Bertolini G, Straumann D: Moving in a moving world: A review on vestibular motion sickness. Front Neurol 2016; 7: 14 CrossRef MEDLINE PubMed Central
12. Lackner JR: Motion sickness: more than nausea and vomiting. Exp Brain Res 2014; 232: 2493–510 CrossRef MEDLINE PubMed Central
13. Schmäl F: Neuronal mechanisms and the treatment of motion sickness. Pharmacology 2013; 91: 229–41 CrossRef MEDLINE
14. Tal D, Hershkovitz D,Kaminski-Graif, Wiener G, Samuel O, Shupak A: Vestibular evoked myogenic potentials and habituation to seasickness. Clin Neurophys 2013; 124: 2445–49 CrossRef MEDLINE
15. Yates BJ, Miller AD, Lucot JB: Physiological basis and pharmacology of motion sickness: an update. Brain Res Bull 1998; 47: 395–406 CrossRef
16.Reason JT: Motion sickness adaptation: a neural mismatch model. J R Soc Med 1978; 71: 819–29 CrossRef
17. Golding JF, Mueller AG, Gresty MA: A motion sickness maximum around the 0.2 Hz frequency range of horizontal translational oscillation. Aviat Space Environ Med 2001; 72: 188–92 MEDLINE
18.Bronstein AM, Golding JF, Gresty MA: Vertigo and dizziness from environmental motion: visual vertigo, motion sickness, and drivers’ disorientation. Semin Neurol 2013; 33: 219–30 CrossRef MEDLINE
19.Golding JF, Gresty MA: Pathophysiology and treatment of motion sickness. Curr Opin Neurol 2015; 28: 83–88 CrossRef MEDLINE
20. von Gierke HE, Parker DE: Differences in otolith and abdominal viscera graviceptor dynamics: implications for motion sickness and perceived body position. Aviat Space Environ Med 1994; 65: 747–51 MEDLINE
21.Golding JF, Gresty MA: Motion sickness. Curr Opin Neurol 2005; 18: 29–34 CrossRef
22.Diels C, Howarth PA: Frequency characteristics of visually induced motion sickness. Hum Factors 2013; 55: 595–604 CrossRef MEDLINE
23. Shupak A, Gordon CR: Motion sickness: advances in pathogenesis, prediction, prevention, and treatment. Aviat Space Environ Med 2006; 77: 1213–23.
24. Takeda N, Morita M, Horii A, Nishiike S, Kitahara T, Uno A: Neural mechanisms of motion sickness. J Med Invest 2001; 48: 44–59.
25.Riccio GE, Stoffregen TA: An ecological theory of motion sickness and postural instability. Ecol Psychol 1991; 3: 195–240 CrossRef
26.Money KE: Motion sickness. Physiol Rev 1970; 50: 1–39 CrossRef MEDLINE
27.Barmack NH: Central vestibular system: vestibular nuclei and posterior cerebellum. Brain Res Bull 2003; 60: 511–41 CrossRef
28.Dieterich M, Brandt T: Functional brain imaging of peripheral and central vestibular disorders. Brain 2008; 131: 2538–52 CrossRef MEDLINE
29.Sclocco R, Kim J, Garcia RG, et al.: Brain circuitry supporting multi-organ autonomic outflow in response to nausea. Cereb Cortex 2016; 26: 485–97.
30.Yates BJ, Catanzaro MF, Miller DJ, McCall AA: Integration of vestibular and emetic gastrointestinal signals that produce nausea and vomiting: potential contributions to motion sickness. Exp Brain Res 2014; 232: 2455–69 CrossRef MEDLINE PubMed Central
31.Jarisch R, Weyer D, Ehlert E, et al.: Impact of oral vitamin C on histamine levels and seasickness. J Vestib Res Equilib Orientat 2014; 24: 281–8.
32.Takeda N, Morita M, Hasegawa S, Horii A, Kubo T, Matsunaga T: Neuropharmacology of motion sickness and emesis. A review. Acta Oto-Laryngol Suppl 1993; 501: 10–5 CrossRef
33. Jarisch R: Histaminintoleranz – Histamin und Seekrankheit. Stuttgart, New York: Georg Thieme 2013; 26–39.
34. van Esch BF, van Wensen E, van der Zaag-Loonen HJ, Benthem PPG van, van Leeuwen RB: Clinical characteristics of benign recurrent vestibulopathy: clearly distinctive from vestibular migraine and menière’s disease? Otol Neurotol Off Publ Am Otol Soc Am Neurotol Soc Eur Acad Otol Neurotol 2017; 38: 357–63.
35. Singh P, Yoon SS, Kuo B: Nausea: a review of pathophysiology and therapeutics. Ther Adv Gastroenterol 2016; 9: 98–112 CrossRefMEDLINE PubMed Central
36.Brainard A, Gresham C: Prevention and treatment of motion sickness. Am Fam Physician 2014; 90: 41–6.
37.Ressiot E, Dolz M, Bonne L, Marianowski R: Prospective study on the efficacy of optokinetic training in the treatment of seasickness. Eur Ann Otorhinolaryngol Head Neck Dis 2013; 130: 263–8 CrossRef MEDLINE
38.Zhang LL, Wang JQ, Qi RR, Pan LL, Li M, Cai YL: Motion sickness: current knowledge and recent advance. CNS Neurosci Ther 2016; 22: 15–24 CrossRef MEDLINE
39. Spinks A, Wasiak J: Scopolamine (hyoscine) for preventing and treating motion sickness. Cochrane Database Syst Rev 2011; 6: CD002851.
40. White B: Ginger: an overview. Am Fam Physician 2007; 75: 1689–91.
e1.Li J, Zhu L, Yuan W, Jin G, Sun J: [Habituation of seasickness in adult during a long voyage]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2012; 47: 642–5 MEDLINE
e2.Graybiel A, Knepton J: Sopite syndrome: a sometimes sole manifestation of motion sickness. Aviat Space Environ Med 1976; 47: 873–82 MEDLINE
e3. Geiger J: Gleichgewichts-, Lage- und Bewegungssinn. In: Pape HC, Kurtz A, Silbernagl S, (eds.): Physiologie (7th edition). Stuttgart: Georg Thieme 2014; 756–68.
e4. Kennedy RS, Drexler J, Kennedy RC: Research in visually induced motion sickness. Appl Ergon 2010; 41: 494–503 CrossRef MEDLINE
e5. O’Hanlon JF, McCauley ME: Motion sickness incidence as a function of the frequency and acceleration of vertical sinusoidal motion. Aerosp Med 1974; 45: 366–9 MEDLINE
e6.Griffin MJ, Mills KL: Effect of frequency and direction of horizontal oscillation on motion sickness. Aviat Space Environ Med 2002; 73: 537–43 MEDLINE
e7.Golding JF. Motion sickness. Handb Clin Neurol 2016; 137: 371–90 CrossRef MEDLINE
e8.von Gierke HE, Parker DE: Differences in otolith and abdominal viscera graviceptor dynamics: implications for motion sickness and perceived body position. Aviat Space Environ Med 1994; 65: 747–51 MEDLINE
e9.Dai M, Kunin M, Raphan T, Cohen B: The relation of motion sickness to the spatial-temporal properties of velocity storage. Exp Brain Res 2003; 151: 173–89 CrossRef MEDLINE
e10.Leger A, Money KE, Landolt JP, Cheung BS, Rodden BE: Motion sickness caused by rotations about earth-horizontal and earth-vertical axes. J Appl Physiol 1981; 50: 469–77 CrossRef MEDLINE
e11. Riccio GE, Stoffregen TA: An ecological theory of motion sickness and postural instability. Ecol Psychol 1991; 3: 195–240 CrossRef
e12.Nooij SA, Vanspauwen R, Bos JE, Wuyts FL: A re-investigation of the role of utricular asymmetries in Space Motion Sickness. J Vestib Res Equilib Orientat 2011; 21: 141–51.
e13. Napadow V, Sheehan JD, Kim J et al.: The brain circuitry underlying the temporal evolution of nausea in humans. Cereb Cortex 2013; 23: 806–13 CrossRef MEDLINE PubMed Central
e14.Watanabe T, Yamatodani A, Maeyama K, Wada H: Pharmacology of alpha-fluoromethylhistidine, a specific inhibitor of histidine decarboxylase. Trends Pharmacol Sci 1990; 11: 363–7 CrossRef
e15.Lucot JB, Takeda N: Alpha-fluoromethylhistidine but not diphenhydramine prevents motion-induced emesis in the cat. Am J Otolaryngol 1992; 13: 176–80 CrossRef
e16.Neuhauser H, Lempert T: Vertigo and dizziness related to migraine: a diagnostic challenge. Cephalalgia Int J Headache 2004; 24: 83–91 CrossRef MEDLINE
e17.Aust G: [Equilibrium disorders and their diagnosis in childhood]. Laryngorhinootologie 1991; 70: 532–7 MEDLINE
e18.Buker TJ, Vincenzi DA, Deaton JE: The effect of apparent latency on simulator sickness while using a see-through helmet-mounted display: reducing apparent latency with predictive compensation. Hum Factors 2012; 54: 235–49 CrossRef MEDLINE
e19. Bonato F, Bubka A, Krueger WWO: A wearable device providing a visual fixation point for the alleviation of motion sickness symptoms. Mil Med 2015; 180: 1268–72 CrossRef MEDLINE
e20. Tal D, Gonen A, Wiener G, et al.: Artificial horizon effects on motion sickness and performance. Otol Neurotol Off Publ Am Otol Soc Am Neurotol Soc Eur Acad Otol Neurotol 2012; 33: 878–85 CrossRef MEDLINE
e21.Wada Y, Nishiike S, Kitahara T, et al.: Effects of repeated snowboard exercise in virtual reality with time lags of visual scene behind body rotation on head stability and subjective slalom run performance in healthy young subjects. Acta Otolaryngol 2016; 136: 1121–4 CrossRef MEDLINE
e22. Robinson KD: Die Wirkung eines reaktiven Trainings auf die Kinetosesymptomatik. Masterarbeit Sportwissenschaft; Christian-Albrechts-Universität zu Kiel 2017.
e23. Keshavarz B, Hecht H: Pleasant music as a countermeasure against visually induced motion sickness. Appl Ergon 2014; 45: 521–7 CrossRef MEDLINE
e24.Keshavarz B, Stelzmann D, Paillard A, Hecht H: Visually induced motion sickness can be alleviated by pleasant odors. Exp Brain Res 2015; 233: 1353–64 CrossRef MEDLINE
e25.Chu H, Li MH, Juan SH, Chiou WY: Effects of transcutaneous electrical nerve stimulation on motion sickness induced by rotary chair: a crossover study. J Altern Complement Med 2012; 18: 494–500 CrossRef MEDLINE
e26. Chu H, Li MH, Huang YC, Lee SY: Simultaneous transcutaneous electrical nerve stimulation mitigates simulator sickness symptoms in healthy adults: a crossover study. BMC Complement Altern Med 2013; 13: 84 CrossRef MEDLINE PubMed Central
e27. Bruce DG, Golding JF, Hockenhull N, Pethybridge RJ: Acupressure and motion sickness. Aviat Space Environ Med 1990; 61: 361–5 MEDLINE
e28.Lee A, Fan LT: Stimulation of the wrist acupuncture point P6 for preventing postoperative nausea and vomiting. Cochrane Database Syst Rev 2009 CD003281 MEDLINE PubMed Central
e29.Müller V, Remus K, Hoffmann V, Tschöp MH, Meissner K: Effectiveness of a placebo intervention on visually induced nausea in women—a randomized controlled pilot study. J Psychosom Res 2016; 91: 9–11 CrossRef MEDLINE
e30.Weimer K, Horing B, Muth ER, Scisco JL, Klosterhalfen S, Enck P: Different disclosed probabilities to receive an antiemetic equally decrease subjective symptoms in an experimental placebo study: to be or not to be sure. Clin Ther 2017; 39: 487–501 CrossRef MEDLINE
e31.Horing B, Weimer K, Schrade D, et al.: Reduction of motion sickness with an enhanced placebo instruction: an experimental study with healthy participants. Psychosom Med 2013; 75: 497–504 CrossRef MEDLINE
e32.Hahn A, Sejna I, Stefflova B, Schwarz M, Baumann W: A fixed combination of cinnarizine/dimenhydrinate for the treatment of patients with acute vertigo due to vestibular disorders : a randomized, reference-controlled clinical study. Clin Drug Investig 2008; 28: 89–99 CrossRef
e33.Hahn A, Novotný M, Shotekov PM, Cirek Z, Bognar-Steinberg I, Baumann W: Comparison of cinnarizine/dimenhydrinate fixed combination with the respective monotherapies for vertigo of various origins. Clin Drug Investig 2011; 31: 371–83 CrossRef MEDLINE
e34.Novotný M, Kostrica R: Fixed combination of cinnarizine and dimenhydrinate versus betahistine dimesylate in the treatment of Ménière’s disease: a randomized, double-blind, parallel group clinical study. Int Tinnitus J 2002; 8: 115–23 MEDLINE
e35.Scholtz AW, Schwarz M, Baumann W, Kleinfeldt D, Scholtz HJ: Treatment of vertigo due to acute unilateral vestibular loss with a fixed combination of cinnarizine and dimenhydrinate: a double-blind, randomized, parallel-group clinical study. Clin Ther 2004; 26: 866–77 CrossRef
e36.Rubner O, Kummerhoff PW, Haase H: [An unusual case of psychosis caused by long-term administration of a scopolamine membrane patch. Paranoid hallucinogenic and delusional symptoms]. Nervenarzt 1997; 68: 77–9 CrossRef MEDLINE
e37.Hoffman T: Ginger: an ancient remedy and modern miracle drug. Hawaii Med J 2007; 66: 326–7 MEDLINE
e38.Grøntved A, Brask T, Kambskard J, Hentzer E: Ginger root against seasickness. A controlled trial on the open sea. Acta Otolaryngol 1988; 105: 45–9 CrossRef MEDLINE
e39. Domeyer JE, Cassavaugh ND, Backs RW: The use of adaptation to reduce simulator sickness in driving assessment and research. Accid Anal Prev 2013; 53: 127–32 CrossRef MEDLINE
e40. Micarelli A, Viziano A, Augimeri I, Micarelli D, Alessandrini M: Three-dimensional head-mounted gaming task procedure maximizes effects of vestibular rehabilitation in unilateral vestibular hypofunction: a randomized controlled pilot trial. Int J Rehabil Res Int Z Rehabil Rev Int Rech Readaptation 2017; 40: 325–32.
e41. Buker TJ, Vincenzi DA, Deaton JE: The effect of apparent latency on simulator sickness while using a see-through helmet-mounted display: reducing apparent latency with predictive compensation. Hum Factors 2012; 54: 235–49 CrossRef MEDLINE
e42. Russell MEB, Hoffman B, Stromberg S, Carlson CR: Use of controlled diaphragmatic breathing for the management of motion sickness in a virtual reality environment. Appl Psychophysiol Biofeedback 2014; 39: 269–77 CrossRef MEDLINE
e43. Stromberg SE, Russell ME, Carlson CR: Diaphragmatic breathing and its effectiveness for the management of motion sickness. Aerosp Med Hum Perform 2015; 86: 452–7 CrossRef MEDLINE
e44. Cha YH, Urbano D, Pariseau N: Randomized single blind sham controlled trial of adjunctive home-based tDCS after rTMS for mal de debarquement syndrome: safety, efficacy, and participant satisfaction assessment. Brain Stimulat 2016; 9: 537–44 CrossRef MEDLINE
e45.Cha YH, Deblieck C, Wu AD: Double-blind sham-controlled crossover trial of repetitive transcranial magnetic stimulation for mal de debarquement syndrome. Otol Neurotol Off Publ Am Otol Soc Am Neurotol Soc Eur Acad Otol Neurotol 2016; 37: 805–12 CrossRef MEDLINE PubMed Central
e46. Golding JF: Motion sickness susceptibility. Auton Neurosci 2006; 129: 67–76 CrossRef MEDLINE
e47. Gil A, Nachum Z, Tal D, Shupak A: A comparison of cinnarizine and transdermal scopolamine for the prevention of seasickness in naval crew: a double-blind, randomized, crossover study. Clin Neuropharmacol 2012; 35: 37–9 CrossRef MEDLINE
e48.Sherman CR: Motion sickness: review of causes and preventive strategies. J Travel Med 2002; 9: 251–6 MEDLINE
e49.Zajonc TP, Roland PS: Vertigo and motion sickness. Part II: pharmacologic treatment. Ear Nose Throat J 2006; 85: 25–35 MEDLINE
e50. Nachum Z, Shupak A, Gordon CR: Transdermal scopolamine for prevention of motion sickness: clinical pharmacokinetics and therapeutic applications. Clin Pharmacokinet 2006; 45: 543–66 MEDLINE
e51. Estrada A, LeDuc PA, Curry IP, Phelps SE, Fuller DR: Airsickness prevention in helicopter passengers. Aviat Space Environ Med 2007; 78: 408–13 MEDLINE
e52.Brand JJ, Colquhoun WP, Gould AH, Perry WL: (—)-Hyoscine and cyclizine as motion sickness remedies. Br J Pharmacol Chemother 1967; 30: 463–9 CrossRef
e53.Paul MA, MacLellan M, Gray G: Motion-sickness medications for aircrew: impact on psychomotor performance. Aviat Space Environ Med 2005; 76: 560–5 MEDLINE
e54.Gordon CR, Shupak A: Prevention and treatment of motion sickness in children. CNS Drugs 1999; 12: 369–81 CrossRef
e55. Cheung BS, Heskin R, Hofer KD: Failure of cetirizine and fexofenadine to prevent motion sickness. Ann Pharmacother 2003; 37: 173–7.